Category: 134-96-3

Komakech, Richard published the artcileGC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark, Application In Synthesis of 134-96-3, the publication is Scientific Reports (2022), 12(1), 7044, database is CAplus and MEDLINE.

Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochem. profile and hepatotoxicity effects in zebrafish larvae of the stem bark extracts of P. africana. Mouse bone marrow macrophages (BMM) cells were plated in 96-well plates and treated with P. africana methanolic bark extracts at concentrations of 0, 6.25, 12.5, 25, and 50 μg/mL for 24 h. The osteoclast tartrate-resistant acid phosphatase (TRAP) activity and cell viability were measured. Lipopolysaccharides (LPS) induced Nitrite (NO) and interleukin-6 (IL-6) production inhibitory effects of P. africana bark extracts (Methanolic, 150 μg/mL) and β-sitosterol (100 μM) were conducted using RAW 264.7 cells. Addnl., inhibition of IL-1β secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and β-sitosterol. For toxicity study, zebrafish larvae were exposed to different concentrations of 25, 50, 100, and 200 μg/mL P. africana methanolic, ethanolic and water bark extracts DMSO (0.05%) was used as a neg. control and tamoxifen (5 μM) and dexamethasone (40 μM or 80 μM) were pos. controls. The methanolic P. africana extracts significantly inhibited (p < 0.001) TRAP activity at all concentrations and at 12.5 and 25 μg/mL, the extract exhibited significant (p < 0.05) BMM cell viability. NO production was significantly inhibited (all p < 0.0001) by the sample. IL-6 secretion was significantly inhibited by P. africana methanolic extract (p < 0.0001) and β-sitosterol (p < 0.0001) and further, chlorogenic acid and naringenin remarkably inhibited IL-1β production The P. africana methanolic extract significantly inhibited RANKL-induced TRAP activity. The phytochem. study of P. africana stem bark revealed a number of chem. compounds with anti-osteoporosis activity. There was no observed hepatocyte apoptosis in the liver of zebrafish larvae. In conclusion, the stem bark of P. africana is non-toxic to the liver and its inhibition of TRAP activity makes it an important source for future anti-osteoporosis drug development.

Scientific Reports published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Application In Synthesis of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ibrahim, A. Mohammed published the artcileAntimicrobial new Schiff base polyesters: design, thermal, and structural characterizations, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Polymer Bulletin (Heidelberg, Germany) (2022), 79(2), 1119-1132, database is CAplus.

In this work, a series of isovanillin-or syringaldehyde-based new Schiff base monomers were synthesized and polymerized using terephthaloyl chloride by solution condensation polymerization technique. Both the monomers and polymers were characterized by FT-IR, ¹H-NMR, and ¹³C-NMR. The thermal and mol. weight properties were determined by thermogravimetric anal. (TGA) and Gel permeation chromatog. (GPC). The antimicrobial activities of the polyesters were evaluated based on min. inhibition concentration against bacteria such as Escherichia coli, Vibrio parahaemolyticus, and staphylococcus aureus as well as fungi such as Candida albicans and Aspergillus niger. The results of inhibition zones showed that new Schiff base polyesters had good antimicrobial activity.

Polymer Bulletin (Heidelberg, Germany) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sahiba, Nusrat published the artcileA facile biodegradable chitosan-SO₃H catalyzed acridine-1,8-dione synthesis with molecular docking, molecular dynamics simulation and density functional theory against human topoisomerase II beta and Staphylococcus aureus tyrosyl-tRNA synthetase, SDS of cas: 134-96-3, the publication is Journal of Molecular Structure (2022), 133676, database is CAplus.

An efficient and ecobenign pseudo one-pot multicomponent synthesis of I [R = Me, Et, Ph, etc,] was investigated using biodegradable and heterogeneous catalyst, chitosan-SO₃H under ambient reaction conditions. The highly proficient reaction of dimedone, aldehydes, and ammonium acetate in aqueous ethanol using chitosan-SO₃H catalyst at room temperature showed high yields in short reaction time. The bioactivity of mols. was further studied through mol. docking and mol. dynamics simulations, protein-ligand interaction energy calculations and DFT studies. Among all, acridinedione compounds I [R = 4-methoxyphenyl], I [R = 4-cyanophenyl], I [R = 4-hydroxyphenyl] and I [R = 4-(benzyloxy)phenyl] (- 10.8 kcal/mol), I [R = 3-nitrophenyl], I [R = 4-nitrophenyl], I [R = 3,4-dimethoxyphenyl]were the most potent against Human Topoisomerase II beta (3QX3) and Staphylococcus aureus (S. aureus) tyrosyl-tRNA synthetase (1JIJ), resp. and displayed good binding affinity and interaction pattern. Easy availability of substrate and catalyst, use of biodegradable and recyclable polymeric solid acid catalyst, avoid the use of toxic and metallic reagents, operational simplicity, no need of column chromatog., easy workup, clean reaction profile, high yields (70-95%) and purity in short time period (3-12 min) with wide substrate scope (32 derivatives including 10 novel) and broad spectrum of bioactivity are notable advantages of the present protocol.

Journal of Molecular Structure published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, SDS of cas: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gonzalez-Dominguez, Raul published the artcileHigh-Throughput Method for Wide-Coverage and Quantitative Phenolic Fingerprinting in Plant-Origin Foods and Urine Samples, HPLC of Formula: 134-96-3, the publication is Journal of Agricultural and Food Chemistry (2022), 70(25), 7796-7804, database is CAplus and MEDLINE.

The use of mass spectrometry is currently widespread in polyphenol research because of its sensitivity and selectivity, but its usual high cost, reduced robustness, and nonavailability in many anal. laboratories considerably hinder its routine implementation. Herein, we describe the optimization and validation of a high-throughput, wide-coverage, and robust metabolomics method based on reversed-phase ultra-high-performance liquid chromatog. with diode array detection for the identification and quantification of 69 phenolic compounds and related metabolites covering a broad chem. space of the characteristic secondary metabolome of plant foods. The method was satisfactorily validated following the Food and Drug Administration guidelines in terms of linearity (4-5 orders of magnitude), limits of quantification (0.007-3.6 mg L^-1), matrix effect (60.5-124.4%), accuracy (63.4-126.7%), intraday precision (0.1-9.6%), interday precision (0.6-13.7%), specificity, and carryover. Then, it was successfully applied to characterize the phenolic fingerprints of diverse food products (i.e., olive oil, red wine, strawberry) and biol. samples (i.e., urine), enabling not only the detection of many of the target compounds but also the semi-quantification of other phenolic metabolites tentatively identified based on their characteristic absorption spectra. Therefore, this method represents one step further toward time-efficient and low-cost polyphenol fingerprinting, with suitable applicability in the food industry to ensure food quality, safety, authenticity, and traceability.

Journal of Agricultural and Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Osorio-Gonzalez, Carlos S. published the artcileInhibitor degradation by Rhodosporidium toruloides NRRL 1588 using undetoxified wood hydrolysate as a culture media, Product Details of C9H10O4, the publication is Biomass and Bioenergy (2022), 106419, database is CAplus.

Lignocellulosic biomass has been identified as a renewable and sustainable feedstock to produce liquid hydrolyzates as a suitable substrate to produce a variety of compounds through biochem. processes. Nevertheless, the main challenge to using this substrate is the hydrolysis needed to release fermentable sugars. This pretreatment leads to the production of microbial toxic compounds such as furans, phenols and organic acids. In this work, an oleaginous yeast, R. toruloides NRRL 1588, was used to study its ability to degrade inhibitors in C5 and C6 wood hydrolyzates obtained from forestry residues. The study showed that R. toruloides NRRL 1588 can grow, accumulate lipids, and degrade up to 8.01 mgL-1 h-1 of furfural, 5.63 mgL-1 h-1 of 5-hydroxy Me furfural, 1.70 mgL-1 h-1 of levulinic acid, 1.15 mgL-1 h-1 of syringaldehyde, 0.67 mgL-1 h-1 of vanillin, and 1.03 mgL-1 h-1 of vanillic acid. This work confirms the robustness of R. toruloides NRRL 1588 when grows in wood hydrolyzates containing inhibitory compounds

Biomass and Bioenergy published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gomez-Cruz, Irene published the artcileCombined Extraction and Ethanol Organosolv Fractionation of Exhausted Olive Pomace for Bioactive Compounds, Formula: C9H10O4, the publication is Advanced Sustainable Systems (2022), 6(4), 2100361, database is CAplus.

The olive pomace oil extracting industry generates large amounts of exhausted olive pomace (EOP), a lignocellulosic waste that needs to be managed according to sustainable criteria. The aim of this work is to devise an integrated strategy to valorize EOP by applying two-step extraction, and to evaluate the effect of an ethanol organosolv pretreatment on the delignification and enzymic hydrolysis of the extracted EOP. Once the extraction and organosolv pretreatment conditions are selected, solubilized lignin is recovered from the pretreatment liquor using different methods. In addition to those organosolv lignin samples, a lignin-rich solid is obtained after enzymic saccharification of the pretreated solid. All the lignin samples are fully characterized aiming at further valorization. The selected two-step aqueous extraction (85 °C, 90 min, 10% biomass) removes 89% of the extractives content in raw EOP and achieves the full recovery of phenols and mannitol content in that fraction, 4.7 mg gallic acid equivalent per g EOP and 4.5 mg g^-1 EOP, resp. The organosolv pretreatment (50% ethanol catalyzed with 1% H₂SO₄, 140 °C, 60 min, 15% biomass) results in a delignified solid with 81% of enzymic digestibility and a high purity organosolv lignin (>71%), rich in guaiacyl units.

Advanced Sustainable Systems published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hwang, Jimin published the artcileSynthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents, Application of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Bioorganic & Medicinal Chemistry (2022), 116653, database is CAplus and MEDLINE.

Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols.

Bioorganic & Medicinal Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Application of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dominguez-Rodriguez, Gloria published the artcileComposition of Nonextractable Polyphenols from Sweet Cherry Pomace Determined by DART-Orbitrap-HRMS and Their In Vitro and In Vivo Potential Antioxidant, Antiaging, and Neuroprotective Activities, Related Products of ethers-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2022), 70(26), 7993-8009, database is CAplus and MEDLINE.

Sweet cherry pomace is an important source of phenolic compounds with beneficial health properties. As after the extraction of phenolic compounds, a phenolic fraction called nonextractable polyphenols (NEPs) remains usually retained in the extraction residue, alk. and acid hydrolyzes and enzymic-assisted extraction (EAE) were carried out in this work to recover NEPs from the residue of conventional extraction from sweet cherry pomace. In vitro and in vivo evaluation of the antioxidant, antihypertensive, antiaging, and neuroprotective capacities employing Caenorhabditis elegans was achieved for the first time. Extractable phenolic compounds and NEPs were separated and identified by families by high-performance thin-layer chromatog. (HPTLC) with UV/Vis detection. A total of 39 phenolic compounds were tentatively identified in all extracts by direct anal. in real-time high-resolution mass spectrometry (DART-Orbitrap-HRMS). EAE extracts presented the highest in vitro and in vivo antioxidant capacity as well as the highest in vivo antiaging and neuroprotective capacities. These results showed that NEPs with interesting biol. properties are retained in the extraction residue, being usually underestimated and discarded.

Journal of Agricultural and Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Luong, Tuan Minh published the artcileTotal Asymmetric Synthesis and Stereochemical Confirmation of (+)- and (-)-Lyoniresinol and Its Deuterated Analogues, Quality Control of 134-96-3, the publication is Journal of Organic Chemistry (2022), 87(6), 4254-4262, database is CAplus and MEDLINE.

Lyoniresinol and its derivatives are lignans which have been isolated from a plethora of plant species. In addition to exhibiting a range of interesting biol. activities including anticancer, anti-inflammatory, antimicrobial, and others, these compounds have also been discovered in wines and spirits and shown to have gustatory effects in these alc. matrixes. (+)-Lyoniresinol 1 is reported to impart a strong bitter taste while its enantiomer (-)-lyoniresinol 2 is tasteless. The first total asym. synthesis of both natural enantiomers (+)-1 and (-)-2 and their deuterated analogs (D₄)-(+)-3 and (D₄)-(-)-4 has been achieved, confirming the structure and stereochem. of the natural products. The synthesized compounds can be utilized as internal standards in stable isotope dilution anal. for improving and optimizing the existing lyoniresinol quantitation methods in the future.

Journal of Organic Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bankole, Paul Olusegun published the artcileNovel laccase from Xylaria polymorpha and its efficiency in the biotransformation of pharmaceuticals: Optimization of operational conditions, comparative effect of redox-mediators and toxicity studies, COA of Formula: C9H10O4, the publication is Colloids and Surfaces, B: Biointerfaces (2022), 112675, database is CAplus and MEDLINE.

The promising potentials of biocatalytic treatment processes in the removal of micropollutants while eliminating health and environmental hazards have attracted great attention in recent years. This current work investigated the biotransformation efficiency of a novel laccase from Xylaria polymorpha (XPL) in comparison with com. laccases from Trametes versicolor (TVL) and Aspergillus sp. (ASL). XPL exhibited better oxidation performance (95.7%) on AMX than TVL (92.8%) and ASL (90.5%). Optimization of operational conditions revealed that AMX was best oxidized at pH 5, temperature (30 °C), and concentration (1.0 mg L^-1). The investigation carried out to determine the effect of redox mediators revealed violuric acid (VLA) as the best redox mediator. The laccase stability experiments elucidated that the oxidation of AMX is time and mediator concentration dependent with ABTS exhibiting highest deactivation of XPL active sites. Two metabolic products; amoxicillin penilloic acid and 5-hydroxy-6-(4-hydroxyphenyl)- 3-(1,3-thiazolidin-2-yl)piperazin-2-one of AMX were obtained through Liquid Chromatog.-Mass Spectrometry (LC-MS) analyses. The toxicity assessments carried out after oxidation of AMX by XPL showed 94% and 97% reduced toxicity on Artemia salina and Aliivibrio fischeri resp. The study further underscored the efficiency of biocatalytic-mediator technol. in the transformation of complex micropollutants into less toxic substances in an eco-friendly way.

Colloids and Surfaces, B: Biointerfaces published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, COA of Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem