Category: 126829-31-0

Synthetic Route of 126829-31-0,Some common heterocyclic compound, 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A THF solution (0.2 mL) of PdCl2(MeCN)2 (3.9 mg, 0.015 mmol) and 2b (10.2 mg, 0.015 mmol) was stirred for 10 min. To the solution were added diiodoparacyclophane 6 (0.05 mmol) in THF (0.8 mL), i-Pr2NH (0.2mL), alkyne 7 (0.2 mmol) and CuI (2.9 mg, 0.015 mmol) in order. The resulting mixture was stirred at room temperature. After the reaction was complete, H2O was added to the reaction mixture, and organic materials were extracted with AcOEt. The organic layer was washed with brine and dried with Na2SO4. The solvent was removed under reduced pressure, and the crude products were purified by thin-layer chromatography to give dialkynylated product 8.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethynyl-1,3-dimethoxybenzene, its application will become more common.

Reference:
Article; Kanda, Kazumasa; Oshima, Shoya; Shizuno, Tsubasa; Hamanaka, Risa; Fukai, Miku; Shibata, Takanori; Heterocycles; vol. 8; 2; (2014); p. 1355 – 1370;,
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Ether | (C2H5)2O – PubChem

Application of 126829-31-0, A common heterocyclic compound, 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, molecular formula is C10H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The arylalkyne 1,acetic anhydride (Ac2O), and an anhydrous solvent were added to a dried three-necked flask under argon atmosphere and the mixture was stirred for 30 min at room temperature. Further, HCl(g)prepared using H2SO4 and NaCl at 160 8C was added to the mixture through the rubber tube until the starting material conversed completely, monitored by TLC, and the unreacted HCl(g) was absorbed by aqueous NaOH. The solvent was removed and the residue was purified using flash chromatography on a silica gel.

The synthetic route of 126829-31-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Cai-Xia; Ma, Cun-Hua; Xiao, Fu-Rong; Chen, Hong-Wei; Dai, Bin; Chinese Chemical Letters; vol. 27; 11; (2016); p. 1683 – 1685;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H10O2

General procedure: 1 ethynyl 2-methoxybenzene (2a) (265 mg, 2 mmol) and phenylazide (238 mg, 2 mmol) were added in 8 mL of a water and tertbutanol(1:1) mixture. Then 200 mL of freshly prepared 1 M aq.solution of sodium ascorbate (0.2 mmol) was added, following theaddition of 65 mL of aq. CuSO4*5H20 (5 mg, 0.02 mmol) solution. Thereaction mixture was stirred for approximately 14 h at room temperatureand reaction progress was monitored by TLC until its reactantswere completely consumed. Then 30 mL of ice cold waterwas poured into the reaction mixture and flask put in ice bath for15 min following the filtration to get white precipitate that werethoroughly rinsed with cold water (2 x 15 mL). The collected solidwas dried under vacuum to get pure product [23,24].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 126829-31-0, its application will become more common.

Reference:
Article; Jabeen, Sobia; Khera, Rasheed Ahmad; Iqbal, Javed; Asgher, Muhammad; Journal of Molecular Structure; vol. 1206; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 126829-31-0, The chemical industry reduces the impact on the environment during synthesis 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

Example 29; [0139] l,3-Bis(2,6-diisopropylphenyl)-4-(2,6-dimethoxyphenyl)-lH-l,2,3-triazolium hexafluorophosphate (lOal). To a stirred suspension of triazene 8a (3.66 g, 10 mmol), 2,6- dimethoxyphenylacetylene 91 (3.24 g, 20 mmol), and anhydrous potassiumhexafluorophosphate (1.84 g, 10 mmol) in dry dichloromethane (50 mL) in the dark at -78C is added tert-butyl hypochlorite (1.66 mL, 15 mmol), upon which the mixture instantly darkens. The mixture is stirred overnight as it is slowly allowed to warm to roomtemperature. The contents are then filtered, and the solid residue is washed withdichloromethane. The filtrate is collected, and volatiles are evaporated under reduced pressure. Diethyl ether is then added, and the mixture is vigorously triturated for ca. Ihour, with occasional scratching of the glass surfaces to ensure efficient mixing. Filtration and washing with copious quantities of diethyl ether afford, after drying under vacuum, triazolium salt lOai as an off-white solid (5.25 g, 78%). Analytical samples were obtained after recrystallization by vapor diffusion of diethyl ether in an acetonitrile solution of lOai. 1H-NMR ((CD3)2SO, 300 MHz): delta = 10.03 (s, 1H), 7.79 (t, J = 7.9 Hz, 1H), 7.64-7.57 (m, 3H), 7.54 (t, J = 7.9 Hz, 1H), 7.42 (d, J = 7.9 Hz, 2H), 6.78 (d, J = 8.5 Hz, 2H), 3.71 (s, 6H), 2.43 (sept, J = 6.8 Hz, 2H), 2.29 (sept, J = 6.8 Hz, 2H), 1.27 (d, J = 6.8 Hz, 6H), 1.17 (d, J = 6.8 Hz, 6H), 1.08 (d, J = 6.8 Hz, 6H), 0.99 (d, J = 6.8 Hz, 6H). 13C-NMR ((CD3)2SO, 75 MHz): delta = 158.4, 145.2, 144.7, 139.9, 136.4, 135.2, 133.3, 132.9, 130.2, 129.2, 125.0, 124.8, 104.7, 98.0, 56.9, 28.8, 28.6, 25.8, 23.8, 23.1, 21.7. HR-MS (ESI): Calcd. for C34H44N302 [M+]: 526.3428, found 526.3433.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethynyl-1,3-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BERTRAND, Guy; GUISADO-BARRIOS, Gregorio; BOUFFARD, Jean; DONNADIEU, Bruno; WO2011/139704; (2011); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem