Category: 123652-95-9

Synthetic Route of 123652-95-9, The chemical industry reduces the impact on the environment during synthesis 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, I believe this compound will play a more active role in future production and life.

To a screw-capped vial equipped with a magnetic stir bar were added 3,4- dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (Intermediate 2) (35 mg, 0.17 mmol), DMF (1 mL), DIEA (90 tL, 0.48 mmol), and HATU (77 mg, 0.20 mmol). This mixture was allowed to stir at ambient temperature for 30 minutes, and then excess (3-fluoro-4- methoxyphenyl)methanamine (2.1) was added. After stirring at room temperature for 30 minutes, purification by reversed-phase HPLC (eluting with water/0. 1% trifluoroacetic acid and acetonitrile) afforded the title compound. LCMS: RT = 0.81 mm, >99% 254 nm,>99% 215 nm; mlz (M + 1)= 346. ?H NMR (400 MHz, d6-DMSO) oe 9.5 (t, J= 5.8 Hz, 1H), 8.3 (s, 1H), 7.1-7.3 (m, 3H), 4.5 (d, J= 5.8 Hz, 2H), 3.8 (s, 3H), 2.7 (s, 3H), 2.6 (s, 3H); HRMS calculated for C,7H,6FN302S (M+H) mlz: 346.1026, measured: 346.1023.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; POSLUSNEY, Michael, S.; TARR, James, C.; MELANCON, Bruce, J.; WO2015/27214; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, molecular formula is C8H10FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 123652-95-9

Compound 33; To a solution of compound 32 (0.185 mmol, 100 mg, 1.0 equiv.) in NMP (2 ml) was added 3- fluoro-4-methoxybenzylamine (1.850 mmol, 287 mg, 10 equiv.). The reaction mixture was heated to 100 0C and stirred overnight. Mixture was then poured into H2O and extracted withEtOAc. The combined organic layers were washed with water and brine, dried (Na2SC>4), filtered and concentrated in vacuo. 70 mg of compound 33 was obtained in 62% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 123652-95-9, its application will become more common.

Reference:
Patent; N.V. ORGANON; PHARMACOPEIA INC.; WO2008/51826; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem