Category: 123652-95-9

Electric Literature of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1. Model canadense amide quinones (DCA – CONH – 07) preparation, comprising the following steps:

The synthetic route of (3-Fluoro-4-methoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong University of Technology; Zhao Suqing; Zhang Bingjie; Feng Dongyan; Fang Yinglin; Wu Ke; Ling Huaying; Tan Qiting; Chen Yanting; Yang Yang; Zhao Jiawei; Ma Zhuolin; Hong Weiqian; (24 pag.)CN109651183; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

6-Amino-N-(3-fluoro-4-methoxybenzyl)-2,5-dimethylthieno[3,2-e][1,2,4]triazolo[1,5-a]pyridine-7-carboxamide (Compound 2) In a vial equipped with a magnetic stir bar was added HATU (1.2 eq), compound E (1.0 eq), and DIEA (4.1 eq) in DMF (0.2 M). After 10 min, (3-fluoro-4-methoxyphenyl)methanamine (2.0 eq) was added. After 16 h, LCMS showed desired product. The reaction was passed through a syringe filter and purified by prep RP-HPLC Gilson, eluting 15-75% MeCN/water+0.1% TFA. Desired fractions were concentrated, in order to remove the acetonitrile. To the remaining aqueous mixture was added sat’d NaHCO3 and the mixture was extracted with EtOAc (3*). The collected organic layers were dried (MgSO4), filtered and concentrated to afford the desired product (37-48% yield). LCMS: RT=0.905 min, >98% 215 and 254 nM, m/z=400.2 [M+H]+. 1H NMR (400 MHz, d6-DMSO): delta 8.43 (t, J=5.8, 1H), 7.40 (s, 1H), 7.17-7.08 (m, 3H), 7.04 (s, 2H), 4.36 (d, J=5.8 Hz, 2H), 3.81 (s, 3H), 2.80 (s, 3H).

The synthetic route of (3-Fluoro-4-methoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Vanderbilt University; Lindsley, Craig W.; Conn, P. Jeffrey; Engers, Darren W.; Jones, Carrie K.; Bridges, Thomas M.; Han, Changho; Felts, Andrew S.; (38 pag.)US2018/28501; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00330] To a solution of compound 2, 19 and Et3N in DMF at rt. then HATU was added at rt.After stirring for lh at rt, the reaction was diluted with water and extracted with EA, washed byK2C03 and brine, dried over Na2SO4 and concentrated and purified by FCC to afford compound20. ?H NMR (400 MHz, CDC13): 3 8.46 (s, 1H), 8.42 (s, 1H), 7.10-7.06 (m, 2H), 6.94-6.90 (m,1H), 6.47-6.44 (m, 1H), 4.57 (d, J = 6.0 Hz, 2H), 3.87 (s, 3H); mlz (ESI+) (M+H)+ = 313.05.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; YANG, Wenjin; CHEN, Che-Hong; MOCHLY-ROSEN, Daria; WO2014/160185; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, A new synthetic method of this compound is introduced below., Formula: C8H10FNO

General procedure: A microvawe vial (ovendried and under argon) was chargedwith the corresponding bromoindazole derivative (1.0 equiv.), theappropriate amine (1.2 equiv.), Pd(OAc)2 (5 mol%), BrettPhos(10 mol%), Cs2CO3 (1.5 equiv.) and anhydrous dioxane (0.2 mmol/mL). The vial was capped properly, flushed with argon and heatedto 120 C overnight. After cooling, the reaction mixture wasconcentrated under vacuum. The crude residue was diluted withwater and the aqueous phase was extracted 3 times with EtOAc.The organic layers were combined, washed with brine, dried overNa2SO4, filtered, concentrated and purified by silica gel columnchromatography, using the appropriate heptanes:EtOAc mixture.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Bollenbach, Maud; Lugnier, Claire; Kremer, Melanie; Salvat, Eric; Megat, Salim; Bihel, Frederic; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 269 – 290;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1. Model canadense amide quinones (DCA – CONH – 07) preparation, comprising the following steps:

The synthetic route of (3-Fluoro-4-methoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong University of Technology; Zhao Suqing; Zhang Bingjie; Feng Dongyan; Fang Yinglin; Wu Ke; Ling Huaying; Tan Qiting; Chen Yanting; Yang Yang; Zhao Jiawei; Ma Zhuolin; Hong Weiqian; (24 pag.)CN109651183; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

6-Amino-N-(3-fluoro-4-methoxybenzyl)-2,5-dimethylthieno[3,2-e][1,2,4]triazolo[1,5-a]pyridine-7-carboxamide (Compound 2) In a vial equipped with a magnetic stir bar was added HATU (1.2 eq), compound E (1.0 eq), and DIEA (4.1 eq) in DMF (0.2 M). After 10 min, (3-fluoro-4-methoxyphenyl)methanamine (2.0 eq) was added. After 16 h, LCMS showed desired product. The reaction was passed through a syringe filter and purified by prep RP-HPLC Gilson, eluting 15-75% MeCN/water+0.1% TFA. Desired fractions were concentrated, in order to remove the acetonitrile. To the remaining aqueous mixture was added sat’d NaHCO3 and the mixture was extracted with EtOAc (3*). The collected organic layers were dried (MgSO4), filtered and concentrated to afford the desired product (37-48% yield). LCMS: RT=0.905 min, >98% 215 and 254 nM, m/z=400.2 [M+H]+. 1H NMR (400 MHz, d6-DMSO): delta 8.43 (t, J=5.8, 1H), 7.40 (s, 1H), 7.17-7.08 (m, 3H), 7.04 (s, 2H), 4.36 (d, J=5.8 Hz, 2H), 3.81 (s, 3H), 2.80 (s, 3H).

The synthetic route of (3-Fluoro-4-methoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Vanderbilt University; Lindsley, Craig W.; Conn, P. Jeffrey; Engers, Darren W.; Jones, Carrie K.; Bridges, Thomas M.; Han, Changho; Felts, Andrew S.; (38 pag.)US2018/28501; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123652-95-9, category: ethers-buliding-blocks

In DCM (50 mL) were dissolved ethyl 4-chloro-2-(methylthio)pyrimidine-5 -carboxylate (1.5 g, 6.46 mmol), 3-fluoro-4-methoxybenzylamine (1.0 g, 6.45 mmol) and triethylamine (1.3 g, 12.9 mmol). The reaction mixture was stirred at ambient temperature for 30 min, and washed with water. The organic phase was dried over sodium sulfate and concentrated to give ethyl 4-((3-fluoro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine -5-carboxylate as a yellow oil (2.2 g, yield: 97 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; WANG, Aichen; EP2886540; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 123652-95-9, A common heterocyclic compound, 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Generally, the procedure for the synthesis of 8 (a-w) was as follows. A mixture of substituted acridine (1) and benzylamine(2 equiv) in ethanol (8 mL) was added potassium carbonate(2 equiv) and potassium iodide (2% equiv). The reaction mixturewas stirred for 30 min at room temperature and refluxed in oil bathfor 24-48 h. Then the mixturewas extracted with absolute ethanolto give the crude products, which were purified by column chromatography with petroleum ether and ethyl acetate (5:1 v/v).

The synthetic route of 123652-95-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Wei; Zhang, Bin; Zhang, Wei; Yang, Ti; Wang, Ning; Gao, Chunmei; Tan, Chunyan; Liu, Hongxia; Jiang, Yuyang; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 59 – 70;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 123652-95-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00326] To a solution of compound 15 (2.3 g, 13.5 mmol) in SOd2 ( 20 mL) was refluxed for 4h, The mixture was concentrated and then re-dissolved in DCM (5 mL) and transfeffed to a solution of the amine 2 ( 2.7 g 17.6 mmol) and TEA (4.0 g, 40.5 mmol). The mixture was stirred at rt for 3 h. The resulting mixture was purified by FCC (PE/EA=3:1) to afford the product 16 (3.lg, 75.3%). ?H NMR (400 MHz, CDC13): 8.19 (d, J =4.8 Hz, 1H), 7.11-7.06 (m, 3H), 6.92(t, J = 8.8 Hz, 1H), 6.32-6.28 (m, 1H), 4.55 (d, J = 6.0 Hz, 2H), 3.87 (s, 3H), 2.34 (s, 3H); mlz (ESI+) (M+H)+ = 309.00.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; YANG, Wenjin; CHEN, Che-Hong; MOCHLY-ROSEN, Daria; WO2014/160185; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 123652-95-9

General procedure: Spirothiazamenthane 3 (1.0 eq) was dissolved in toluene (0.1 M concentration) in a microwave vial and the solution was treated with amine (10 eq) and PTSA (20 mol %). This mixture was heated at 150 C using microwaves for 4 h. After cooling, the solvents were removed by evaporation and the resulting residue was taken up in 1:1 Et2O/2M NaOH. The layers were separated and the aqueous layer was extracted 2 ¡Á with Et2O. The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude products were purified as described below. Variations in reaction conditions are also noted below.

The synthetic route of 123652-95-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arns, Steve; Balgi, Aruna D.; Shimizu, Yoko; Pfeifer, Tom A.; Kumar, Nag; Shidmoossavee, Fahimeh S.; Sun, Sharon; Tai, Sheldon S.-H.; Agafitei, Olga; Jaquith, James B.; Bourque, Elyse; Niikura, Masahiro; Roberge, Michel; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 64 – 73;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem