1236000-51-3 Archives - Ethers-buliding-blocks

Simple exploration of 1236000-51-3

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H11ClF3NO

Intermediate 26 {[5-(4-bromophenyl)-2-thienyl]methyl}methyl({4[(trifluoromethyl)oxy]phenyl}methyl)amine (1-[5-(4-bromophenyl)-2-thienyl]-N-methyI-N-({4-[(trifluoromethyl)oxy]phenyl}methyl)methanamine). To a solution of 0.3 g of Intermediate 25 and 0.26 g of Intermediate 1 in 8.5 ml of DCE under N2 atmosphere were added dropwise 0.226 ml of Et3N and 0.342 g of NaHB(AcO)3 consecutively. The mixture was stirred overnight at room temperature and 1 N NaOH was added. The resulting mixture was extracted with CH2CI2, the combined organic layers were dried over Na2SO4, filtered and concentrated to dryness. The crude was purified by chromatography on silica gel eluting with EtOAc-Hex 0:100 to 10:90 to afford 0.383 g of the desired compound with 10% of the starting aldehyde. This mixture was re-purified on silica gel eluting with EtOAc-Hex 0:100 to 10:90 to afford 0.348 g (67%) of the title compound as a colourless oil.1H NMR (delta, ppm, CDCI3): 7.47 (dd, 4H); 7.42 (d, 2H); 7.18 (d, 2H); 7.15 (d, 1 H); 6.90 (d, 1 H); 3.75 (s, 2H); 3.58 (s, 2H); 2.28 (s, 3H). [ES MS] m/z: 456 (MH+).

Reference:
Patent; GLAXO GROUP LIMITED; BUENO-CALDERON, Jose Maria; FERNANDEZ-MOLINA, Jorge; LEON-DIAZ, Maria Luisa; MALLO-RUBIO, Araceli; MANZANO-CHINCHON, M Pilar; WO2010/81904; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Extended knowledge of 1236000-51-3

The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.

Application of 1236000-51-3, A common heterocyclic compound, 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, molecular formula is C9H11ClF3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 28 To a solution of 1.0 g of 3-iodobenzoic acid in 20 ml of CH2CI2 under argon atmosphere was added via cannula a solution of 1.11 g of DCC in 22 ml of CH2CI2. The resulting mixture was stirred for 1 h, then was added a solution of 0.65 g of Intermediate 1 and 0.414 ml of Et3N in 13 ml of CH2CI2. The resulting mixture was stirred overnight, diluted with Et2O, filtered off and the filter cake washed with Et2O. The filtrate was washed with 10% NaHCO3 and brine, dried over MgSO4, filtered and concentrated under vacuum. The residue was purified by chromatography on silica gel eluting with EtOAc-Hex 10:90 to 50:50 to afford 1.063 g (91 %) of the title compound as a colourless oil. 1H NMR (delta, ppm, CDCI3): 7.79 and 7.75 (s, 1 H); 7.39 (s, 1 H); 7.23 (d, 2H); 7.21-7.1 1 (m, 2H); 4.72 and 4.49 (s, 2H); 3.02 and 2.88 (s, 3H). [ES MS] m/z: 436 (MH+).

The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.

Application of C9H11ClF3NO

The synthetic route of N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride has been constantly updated, and we look forward to future research findings.

Application of 1236000-51-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 41 3-butyn-1-yl(methyl)({4-[(trifluoromethyl)oxy]phenyl}methyl)amine (N-methyI-N-({-4-[(trifluoromethyl)oxy]phenyl}methyl)-3-butyn-1-amine). To a solution of Intermediate 1 (0.480 g) in dry acetonitrile (6 ml) under N2 atmosphere were added K2CO3 (0.792 g) and Intermediate 40 (0.324 g) consecutively. The mixture was refluxed for 4 days, then concentrated to dryness under vacuum. EtOAc and H2O were added, the organic layer washed with H2O (2x) and brine (1x), then dried over Na2SO4. Elimination of the solvent under vacuum gave an oil which was purified by column chromatography on silica gel, eluting with a mixture 3% EtOAc/CH2CI2 to afford 0.18O g of the title compound as a colourless liquid.1H NMR (delta, ppm, CDCI3): 7.36 (d, 2H); 7.16 (d, 2H); 3.54 (s, 2H); 2.64 (t, 2H); 2.41 (td, 2H); 2.25 (s, 3H); 1.98 (t, 1 H). [ES MS] m/z 258 (MH+).

The synthetic route of N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride has been constantly updated, and we look forward to future research findings.

Simple exploration of C9H11ClF3NO

The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.

Application of 1236000-51-3,Some common heterocyclic compound, 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, molecular formula is C9H11ClF3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 29 5-bromo-N-methyI-N-({4-[(trifluoromethyl)oxy]phenyl}methyl)-1-benzothiophene-2-carboxamide. In a round bottom flask under argon atmosphere were placed 0.3 g of 5-bromo-1- benzothiophene-2-carboxylic acid, 0.459 g of TOTU (O-[(ethoxycarbonyl)cyanomethyl- enamino]-/V,/V,/V,/V-tetramethyluronium tetrafluoroborate) and 0.423 g of Intermediate 1 in12 ml of CH2CI2. The mixture was cooled to 0 0C and 0.49 ml of Et3N were added. The reaction mixture was stirred overnight at room temperature, then diluted with CH2CI2, washed with 1 N NaOH and brine, dried over Na2SO4, filtered and concentrated to dryness under vacuum. The residue was purified by chromatography on silica gel eluting withEtOAc-Hex 10:90 to 20:80 to afford 0.471 mg (91%) of the titled compound as a pale yellow oil.1H NMR (delta, ppm, DMSO-d6-80C): 8.11 (s, 1 H); 7.94 (d, 1 H); 7.73 (s, 1 H); 7.55 (dd, 1 H);7.42 (d, 2H); 7.33 (d, 2H); 4.75 (s, 2H); 3.12 (s, 3H). [ES MS] m/z: 445 (MH+).

The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.