Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application of C8H11BO4.
Li, Ya-Sheng;Yang, Xi;Zhao, Dong-Sheng;Cai, Yue;Huang, Zhi;Wu, Rui;Wang, Si-Jia;Liu, Gui-Jun;Wang, Jian;Bao, Xiao-Ze;Ye, Xin-Yi;Wei, Bin;Cui, Zi-Ning;Wang, Hong research published ã?Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cellã? the research content is summarized as follows. Based on the lead compound I (R = 4-MeOC6H4) obtained from our previous work, a series of furan derivatives I (R = 2-MeOC6H4, 2,3-(MeO)2C6H3, 2H-1,3-benzodioxol-5-yl, etc.) featuring alkyl-substituted phenols and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline were designed and synthesized as reversal agents against P-gp in this paper. Compound I [R = 4-(i-PrO)C6H4 (II)] containing an isopropoxy group possessed good potency against P-gp mediated MDR in MCF-7/ADR (IC50 (doxorubicin) = 0.73μM, RF = 69.6 with 5μM 16 treated). Western blot results and Rh123 accumulation assays showed that II effectively inhibited P-gp efflux function but not its expression. The preliminary structure-activity relationship and docking studies demonstrated that compound II would be a potential P-gp inhibitor. Most worthy of mention is that compound II has achieved satisfactory results in combination with a variety of anti-tumor drugs, such as doxorubicin, paclitaxel, and vincristine. This study forwards a hopeful P-gp inhibitor for overcoming a malignant tumor cell with multidrug resistance setting the basis for further studies.
Application of C8H11BO4, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem