Category: 121-00-6

Zhao, Qiang published the artcileRadical α-addition involved electrooxidative [3 + 2] annulation of phenols and electron-deficient alkenes, Application In Synthesis of 121-00-6, the main research area is phenol alkene electrooxidative regioselective diastereoselective cycloaddition; aryl dihydrobenzofuran preparation green chem.

An electrooxidative [3 + 2] annulation of phenols and electron-deficient alkenes for the synthesis of C3-functionalized 2-aryl-2,3-dihydrobenzofuran derivatives was achieved. The ring construction started by a unique α-addition of carbon radicals derived from anodic oxidation of phenols to electron-deficient alkenes. The subsequent anodic oxidation of the resulting alkyl radical intermediates followed by trapping with the phenolic hydroxy group assembles the 2,3-dihydrobenzofuran core. Such a pathway enabled the installation of various electrophilic functionalities including alkoxycarbonyl, alkylaminocarbonyl, trifluoromethyl, and cyano groups at the C-3 of the 2,3-dihydrobenzofuran framework, which is unattainable by other intermol. reactions. The application of this method for a rapid synthesis of a bioactive natural product was demonstrated.

Chemical Science published new progress about [3+2] Cycloaddition reaction, stereoselective (electrochem.). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Uyanik, Muhammet published the artcileHypoiodite-catalysed oxidative homocoupling of arenols and tandem oxidation/cross-coupling of hydroquinones with arenes, SDS of cas: 121-00-6, the main research area is biarenol biquinone preparation; arenol oxidative homocoupling hypoiodite catalyst; aryl quinone preparation; hydroquinone arene tandem oxidation coupling hypoiodite catalyst.

The hypoiodite-catalyzed oxidative C-C homocoupling of arenols to biarenols or biquinones using aqueous hydrogen peroxide as an oxidant was reported. In addition, by combining hypoiodite catalysis and lipophilic Lewis acid-assisted Bronsted acid catalysis under aqueous conditions, a tandem oxidation/cross-coupling reaction of hydroquinones with electron-rich arenes was achieved. These results highlighted the substantial scope of hypoiodite/acid co-catalysis for use in oxidative coupling reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Biaryls Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lamb, Jessica R. published the artcileCarbonylative, Catalytic Deoxygenation of 2,3-Disubstituted Epoxides with Inversion of Stereochemistry: An Alternative Alkene Isomerization Method, Related Products of ethers-buliding-blocks, the main research area is carbonylative deoxygenation epoxide inversion stereochem catalyst; alkene stereoselective preparation.

Reactions facilitating inversion of alkene stereochem. are rare, sought-after transformations in the field of modern organic synthesis. Although a number of isomerization reactions exist, most methods require specific, highly activated substrates to achieve appreciable conversion without side product formation. Motivated by stereoinvertive epoxide carbonylation reactions, we developed a two-step epoxidation/deoxygenation process that results in overall inversion of alkene stereochem. Unlike most deoxygenation systems, carbon monoxide was used as the terminal reductant, preventing difficult postreaction separations, given the gaseous nature of the resulting carbon dioxide byproduct. Various alkyl-substituted cis- and trans-epoxides can be reduced to trans- and cis-alkenes, resp., in >99:1 stereospecificity and up to 95% yield, providing an alternative to traditional, direct isomerization approaches.

Journal of the American Chemical Society published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iu, Leo published the artcileHigh iso Aldehyde Selectivity in the Hydroformylation of Short-Chain Alkenes, Product Details of C11H16O2, the main research area is iso aldehyde selectivity hydroformylation alkene rhodium phospholane phosphite catalyst; enantioselective catalysis; fluorinated solvents; hydroformylation; phosphorus ligands; rhodium.

The hydroformylation of propene to give predominantly iso-butanal was achieved; class-leading selectivity is possible even at higher temperatures that deliver fast conversion. Racemic Rh complexes of bidentate phospholane phosphites derived from tropos-biphenols and unusual solvent systems are the key to the selectivity observed

Angewandte Chemie, International Edition published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (iso). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Peng-Cheng published the artcileOxidative phenol-arene and phenol-phenol cross-coupling using periodic acid, Application of 4-Hydroxy-3-tert-butylanisole, the main research area is biaryl preparation; arene phenol oxidative cross coupling reaction; phenol oxidative cross coupling reaction; naphthol phenol oxidative cross coupling reaction.

A simple, metal-free protocol for unsym. biaryl coupling using H5IO6 is reported. H5IO6 was evaluated for a novel application in the oxidative cross-coupling of phenol-arene, phenol-phenol, and phenol-naphthol compounds ROH (R = 2,6-dimethoxyphenyl, 2-naphthyl, 5,6,7,8-tetrahydronaphthalen-2-yl, etc.) and R1H (R1 = 2,4,5-trimethoxyphenyl, 2-methoxynaphth-1-yl, N,N-dibenzyl-4-aminophenyl, etc.). In this work, most of the couplings were completed within 30 min at ambient temperature 30 coupling products, e.g., 4-(2-(dimethylamino)naphthalen-1-yl)-2,6-dimethylphenol were conveniently obtained using only 0.5 equiv of H5IO6 in HFIP. A mechanism by which the transformation occurs is proposed.

Tetrahedron published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application of 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Kai published the artcileSelective demethoxylation of guaiacol to alkylphenols in supercritical methanol over a HT-MoS2 catalyst, Synthetic Route of 121-00-6, the main research area is demethoxylation guaiacol alkylphenol supercritical methanol HTMoS catalyst.

The high value-added products such as alkyl substituted phenols (A-Ps) are very important from lignin-derived feedstocks. Herein, the selective conversion of guaiacol, an important chem. of lignin-derived bio-oil, to A-Ps over hydrothermally synthesized bulk MoS2 (HT-MoS2) was examined under supercritical methanol conditions without any gaseous hydrogen input. HRTEM confirms the formation of MoS2 with the nanosheet-like structure and XPS anal. exhibited the presence of Mo5+ and S2-2 species which are likely the active species for demethoxylation (DMO) and alkylation of guaiacol. The possible reaction pathways along with their plausible intermediates of guaiacol conversion are proposed. The HT-MoS2 catalyst can be reused up to 4 catalytic runs without loss of its catalytic activity.

Catalysis Today published new progress about Alkylphenols Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Synthetic Route of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tian, Qingqiang published the artcileSelective C-F Bond Etherification of Trifluoromethylalkenes with Phenols, Quality Control of 121-00-6, the main research area is phenoxydifluoromethyl alkene preparation chemoselective insecticidal mol docking.

A novel protocol for the C-F bond etherification of trifluoromethylalkenes and phenols was reported. A variety of alkenyl difluoroaryloxy ethers were obtained with good chemoselectivity and functional group tolerance. DFT calculation results and control experiments suggested that metal ion Cs+ might be involved in this defluorooxylation. Furthermore, the desired product exhibited a good insecticidal activity.

Journal of Organic Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kamitanaka, Tohru published the artcile[3+2] Coupling of Quinone Monoacetals with Vinyl Ethers Effected by Tetrabutylammonium Triflate: Regiocontrolled Synthesis of 2-Oxygenated Dihydrobenzofurans, SDS of cas: 121-00-6, the main research area is dihydrobenzofuran preparation diastereoselective regioselective; quinone monoacetal vinyl ether coupling tetrabutylammonium triflate catalyst.

The synthesis of 2-oxygenated dihydrobenzofurans I (R = H, Me, t-Bu, OMe, NHAc; R1 = H, Me, t-Bu; R2 = Me, Et; R3 = H, OMe; X = -CH2-, -O-; n = 0, 1), II (R4 = Et, i-Pr; R5 = H, Me) involving the [3+2] coupling of quinone monoacetals III with vinyl ethers IV has been realized by tetrabutylammonium triflate catalysis. The reaction involves a new activation method of the acetal moiety in quinone monoacetals III under acid-free conditions affording the highly oxygenated dihydrobenzofurans I, II. This new activation mode was achieved by using the triflate anion catalyst for stabilization of the highly reactive cationic intermediate.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (regio-, stereoselective). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schoen, Florian published the artcileCatalytic Aerobic Phenol Homo- and Cross-Coupling Reactions with Copper Complexes Bearing Redox-Active Guanidine Ligands, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is copper guanidine complex preparation redox potential UV visible spectra; phenol dioxygen copper catalyst chemoselective cross coupling green chem; biphenol preparation; catalysis; cross-coupling; guanidines; phenols; redox-active ligands.

New copper catalysts for the C-C coupling reaction of phenols using dioxygen as a green oxidizing reagent were reported. By using redox-active guanidine ligands, the activity as well as chemoselectivity in the cross-coupling reaction of non-complementary phenols (between an electron-rich phenol and a less nucleophilic second phenol) was significantly improved. Based on the collected data for several test reactions, a reaction mechanism was proposed.

Chemistry – A European Journal published new progress about Biphenyls Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhanderi, Khushboo published the artcileNonconventional driving force for selective oxidative C-C coupling reaction due to concurrent and curious formation of Ag0, Product Details of C11H16O2, the main research area is phenol silver ammonia complex catalyst regieoselective oxidative coupling; biphenyl preparation.

Herein, reduction of [Ag(NH3)2]+ to Ag0 with concurrent oxidation of different phenols/naphthols to biphenyls was undertaken. The work was originated during careful observation of an undergraduate experiment-Tollen’s test-where silver mirror film deposition takes place on the walls of borosilicate glass test tube. When the same reaction was carried out in polypropylene (plastic-Eppendorf) tube, aggregation of Ag0 leading to floating Ag-particles was observed but not silver film deposition. This prompted to carry out challenging cross-coupling reaction by only changing the surface of the reaction flask from glass to plastic to silicones. Surprisingly, good selective oxidative homo-coupling on Teflon surface while cross-coupling in Eppendorf vial was observed Thus, the formation of biphenyl is driven by the macroscopic growth of Ag0 into [Ag-particle] orchestrated by Ag…Ag cohesive interaction was proposed. To validate results, experiments were also performed on gram scale. More importantly, oxidation of β-naphthol carried out in quartz (chiral) tube which yielded slight enantioselective excess of BINOL.

Scientific Reports published new progress about Biphenyls Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem