Category: 1187160-18-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1187160-18-4 as follows. name: 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride

To a stirred solution of ethyl 4-chloro-2-methyIthiopyrimidine-5-carboxylate (2.24 g, 9.62 mmol) in 35 mL of anhydrous tetrahydrofuran was added triethylamine (4.00 mL, 2.90 g, 28.72 mmol). The solution was cooled to 0-5 0C and 7-methoxy-l -aminoindane hydrochloride (2.00 g, 10.01 mmol) was added. The reaction mixture was allowed to warm to room temperature and stirred 48 h. The precipitate was filtered off, washed with ethyl acetate (1 x 25 mL), and the combined filtrates were evaporated to dryness. The residue was dissolved in dichloromethane (35 mL) washed with saturated sodium bicarbonate solution (1 x 17 mL), dried over magnesium sulfate, filtered and concentrated to give 4-(7-methoxy- 2,3-dihydro-l H-inden-l -ylamino)-2-(methylthio)pyrimidine-5-carboxylate as an oil (3.31 g, 9.21 mmol, 95%). ESMS m/z 360 (M+H)+; 1H NMR (400 MHz, CDCl3) delta ppm 8.63 (s, I H), 8.43 (d, J = 6.5 Hz, I H), 7.21 – 7.26 (m, I H), 6.88 (d, J= 7.5 Hz, I H), 6.72 (d, J= 8.3 Hz, I H), 5.69 – 5.78 (m, IH), 4.26 (q, J= 7.2 Hz, 2H), 3.78 (s, 3H), 3.01 – 3.13 (m, I H), 2.82 – 2.94 (m, I H), 2.59 – 2.67 (m, I H), 2.56 (s, 3H), 2.04 – 2.14 (m, IH), 1.33 (t, J= 7.2 Hz, 3H).

According to the analysis of related databases, 1187160-18-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio G.; VOLLRATH, Benedikt; WADE, Warren; WO2010/71846; (2010); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1187160-18-4, name is 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride

Step A: Rac-7-methoxy-indan-1-ylamine hydrochloride (2.20 g, 0.01 1 mmol) was dissolved in acetic acid (100 mL). After cooling to 0 C. sulfuryl chloride (1.88 mL, 0.23 mmol) was slowly added and the reaction mixture was stirred for 16 h at ambient temperature. Then the solvent was evaporated and the residue was taken up in isopropanol. Thereby a precipitate formed which was isolated and dried on high vacuum to yield rac-4,6-dichloro-7-methoxy-indan-1-ylamine (2.0 g, 68%) as a white solid; MS: m/e=269.6 (M+H+).

The synthetic route of 1187160-18-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kolczewski, Sabine; Riemer, Claus; Roche, Olivier; Steward, Lucinda; Wichmann, Juergen; Woltering, Thomas; US2009/227570; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem