Category: 112-59-4

Effects of Surfactants on the Purple Membrane and Bacteriorhodopsin: Solubilization or Aggregation? was written by Ng, Ka Chon;Chu, Li-Kang. And the article was included in Journal of Physical Chemistry B in 2013.Name: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

Using steady-state spectroscopic and zeta potential methods, we have unraveled the interaction of the purple membrane (PM) and bacteriorhodopsin (bR) with various surfactants below their critical micelle concentrations We found that the charged hydrophilic heads of ionic surfactants play a role in perturbing the structure and conformation of PM and bR and that ionic surfactants of opposite charges cause opposing effects. Specifically, the addition of a low concentration (0.2 mM) of the cationic surfactant cetyl trimethylammonium bromide (CTAB) is capable of neutralizing the neg. charged lipids on the PM surface via electrostatic forces. This results in increased hydrophobicity of PM that leads to the aggregation of PM. In contrast, denaturation of PM and bR was observed when the anionic surfactant SDS was added to the PM suspensions. The attachment of SDS to the PM surface increases the solubility of PM and causes a loose crystalline structure. As the SDS concentration is increased to more than 3 mM, the secondary structure of the constituents of bR is significantly distorted, and the protonated Schiff base is hydrolyzed to form free retinal. The addition of the neutral surfactant diethylene glycol mono-n-hexyl ether (C6E2) does not significantly influence the PM and bR, meaning most of their original properties are preserved. We conclude that the addition of surfactants might cause the aggregation or solubilization of the membrane protein, depending on the signs of the charged hydrophilic heads of the surfactants and the charges of the membrane protein surface. Aggregation results when the surfactant and protein have opposite charges, whereas solubilization results when the surfactant and protein have the same charge. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Name: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2-(2-(Hexyloxy)ethoxy)ethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In vitro and in vivo genetic toxicology studies with diethylene glycol monohexyl ether was written by Ballantyne, Bryan;Vergnes, Jane S.. And the article was included in Journal of Applied Toxicology in 2001.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Diethylene glycol monohexyl ether (DEGHE; CAS number 112-59-4), an industrial chem., was investigated for the potential to produce genotoxic effects using 3 in vitro and 2 in vivo tests. No mutagenic activity occurred in either the absence or the presence of metabolic activation with a Salmonella typhimurium reverse assay using strains TA98, TA100, TA1535, TA1537, and TA1538. In a Chinese hamster ovary (CHO) forward gene mutation test (HGPRT locus), there was an increase in the mutation frequencies, which were relatively small compared with the solvent control values, somewhat inconsistent between duplicate cultures, and occurred particularly in the presence of metabolic activation. Linear regression anal. indicated a marginally significant trend for dosage vs. mutation frequency, suggesting that DEGHE was weakly pos. in this test. A sister chromatid exchange test in CHO cells showed no significant dosage-related effects in the presence or absence of metabolic activation. A peripheral blood micronucleus test in mice by dosing with an i.p. injection of DEGHE did not show any potential for DEGHE to increase the incidence of micronucleated polychromatophilic erythrocytes. In a first femoral bone marrow chromosome aberration test in the rat by peroral dosing, DEGHE did not cause any increase in aberrations for 12- and 24-h samples with males and females or with females at 48-h sampling. However, with males at 48 h, the 2 lowest doses showed an increased number of aberrations, but not at the high doses. A repeat study in males with a larger number of doses and 24- and 48-h samples did not replicate this finding. Thus, DEGHE may have limited weak mutagenic activity in vitro but is devoid of clastogenic potential. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C10H22O3

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Photodynamic therapy of human biliary cancer cell line using combination of phosphorus porphyrins and light emitting diode was written by Matsumoto, Jin;Suzuki, Kou;Yasuda, Masahide;Yamaguchi, Yuya;Hishikawa, Yoshitaka;Imamura, Naoya;Nanashima, Atsushi. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Related Products of 112-59-4 The following contents are mentioned in the article:

A series of phosphorus porphyrin complexes ([(RO)₂P(tpp)]Cl, tpp = tetraphenylporphyrinato group, R = -(CH₂CH₂O)_m(CH₂)_nH; 1a: m = 2, n = 2; 1b: m = 2, n = 4; 1c: m = 2, n = 6; 1d: m = 3, n = 6) were used for the photodynamic therapy (PDT) of human biliary cancer cell line (NOZ) when exposed to the irradiation of light emitting diodes (LEDs). A Dulbecco’s modified Eagle’s medium (DMEM) containing NOZ cells (2000 cell well^-1) and 1 (0-100 nM) was introduced into a 96-well microplate and incubated for 24 h to accumulate 1 into the NOZ cells and to multiply the NOZ cells until the cell number reached 10⁴ cells well^-1. After replacing the DMEM medium containing 1 with a fresh DMEM medium without 1, the plates were irradiated for 30 min at 610 nm. After incubation was performed for 24 h in dark conditions, the cell viability of the NOZ cells was determined using the MTT assay. The half maximum inhibitory concentrations 50 (IC₅₀) of 1a-1d were found to be in the range of 33.7-58.7 nM for NOZ. These IC₅₀ values for the NOZ were one hundredth the IC₅₀ value (7.57 μM) for mono-L-aspartyl chlorin e6 (laserphyrin). Thus, it was found that the PDT activity of 1a-1d was much higher than the mono-L-aspartyl chlorin e6. Similarly, IC₅₀ vales of 1a-1d for HeLa cells were found to be 27.8-52.5 nM. This showed that 1a-1d had high photodynamic activity in cancer cells. At the same time, it was speculated that an LED is a useful light source for deactivating the cancer cells because it can excite the sensitizers with peak width in their absorption spectra using the light of the specified wave length with band width of 10-20 nm; LEDs provide a homogeneous light distribution for the target cells. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 112-59-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dynamic interfacial tension and wettability of shale in the presence of surfactants at reservoir conditions was written by Mirchi, Vahideh;Saraji, Soheil;Goual, Lamia;Piri, Mohammad. And the article was included in Fuel in 2015.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

The production of oil from shale formations often requires the utilization of chem. surfactants as additives in fracturing fluids in order to change the characteristics of oil/brine interfaces and/or induce wettability alteration at the shale surface. Although the effect of some surfactants on the interfacial properties of shale oil systems has been investigated in the past, the limited data available in the literature were mainly obtained at ambient conditions and thus may not be representative of fluid-rock interactions at actual reservoir conditions. In this study, a new framework is proposed to investigate the effect of surfactants on fundamental parameters governing fluid displacement in two brine/oil/shale systems (A and B) at reservoir conditions. The critical micelle concentration (CMC) of anionic and nonionic surfactants in brine and their adsorption propensity on shale was first determined by UV-visible spectroscopy and pendant drop method. Rising/captive bubble technique was validated for ultra-low interfacial tension systems then utilized to measure dynamic interfacial tensions and contact angles in the presence of surfactants in Systems A and B at ambient and reservoir conditions. The effects of pressure and temperature, surfactant concentration, and brine chem. on the above-mentioned parameters were investigated in a systematic manner. The results revealed that nonionic surfactants adsorb much less on shales than anionic surfactants. As a result, shale samples used in this study remained strongly water-wet with the nonionic surfactant regardless of surfactant concentration and brine chem. The lowest work of adhesion was obtained right above the CMC, which represents the optimum surfactant concentration Moreover the use of tap water instead of reservoir brine in System B was preferred due to a further reduction in IFT. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C10H22O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Estimating Preferred Alkane Carbon Numbers of Nonionic Surfactants in Normalized Hydrophilic-Lipophilic Deviation Theory from Dissipative Particle Dynamics Modeling was written by Ren, Hua;Zhang, Qiuyu;Zhang, Baoliang;Song, Qingfei. And the article was included in Journal of Physical Chemistry B in 2022.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The preferred alkane carbon number (PACN) in the normalized hydrophilic-lipophilic deviation (HLD_N) theory is a numerical parameter and a transferable scale to characterize the amphiphilicity of surfactants, which is usually measured exptl. using the fish diagram or phase inversion temperature (PIT) methods, and the exptl. measurement can only be applied to existing surfactants. Here, for the first time, we propose a procedure to estimate the PACN of C_iE_j nonionic surfactants directly from dissipative particle dynamics (DPD) simulation. The procedure leverages the method of moment concept to quant. evaluate the bending tendency of nonionic surfactant monolayers by calculating the torque d. Seven nonionic surfactants, C_iE_j (C₆E₂, C₆E₃, C₈E₃, C₈E₄, C₁₀E₄, C₁₂E₄, and C₁₂E₅), with known PACNs are modeled. Two surfactants, C₁₀E₄ and C₆E₂, were first selected to train and test the interaction parameters, and the relationship between interaction parameters and torque d. was mapped for the C₁₀E₄-octane-water system using the artificial neural network (ANN) fitting approach to derive the interaction parameters giving zero torque d., then the interaction parameters were tested in the C₆E₂-dodecane-water system to get the final tuned interaction parameters for PACN estimation With this procedure, we reproduce the PACN values and their trend of seven nonionic surfactants with reasonable accuracy, which opens the door for quant. comparison of surfactant amphiphilicity and surfactant classification in silico using the PACN as a transferable scale. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Safety of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol

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Ether – Wikipedia,
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Response to isopropanol or ionic/non-ionic surfactant in the competitive imbibition of water and alkane into calcium carbonate coating structures was written by Ridgway, Cathy J.;Schoelkopf, Joachim;Gane, Patrick A. C.. And the article was included in Nordic Pulp & Paper Research Journal in 2011.Name: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

This work explores the relationship between polar and non-polar liquids and their interaction with typical porous coating structures, consisting of 100% dispersed calcium carbonate. The effects of addnl. agents, i.e. isopropanol and ionic/non-ionic surfactant are investigated. These agents are currently being employed and developed for the printing industry. Absorption rates into compressed tablets of ground calcium carbonate, with and without the presence of latex, are observed Polyacrylate dispersant, used in manufacture, renders the pigment surface both hydrophilic and hygroscopic, and therefore controls the differential dynamic wetting characteristics of the porous structure for either polar or non-polar liquids In competition with non-polar hexadecane saturating the pore structure of a latex-free sample, polar water displaces the non-polar liquid instantaneously, causing disintegration of the packed porous structure. In the presence of latex binder, however, the structurally destructive pressure is contained, and the uptake of polar water is retarded. The required pre-wetting action of water vapor diffusion on the carbonate polyacrylate dispersant pigment surface is considered to be an integral part of the successful competition between oil and water in the offset printing process, as non-polar oil absorbs steadily into a water pre-saturated structure. Addnl., isopropanol likely promotes miscibility and emulsification more so than ionic/non-ionic surfactant. This behavior possibly relates to the comparative mol. weights of the agents which differentiate their surface energy modifying mechanism from those of the ionic pigment dispersant and binder stabilizers/carboxylation. The use of addnl. agents enables potentially a more homogeneous response to the competitive imbibition environment within the coating structure. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Name: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: 2-(2-(Hexyloxy)ethoxy)ethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and property of alkyl dioxyethyl α-D-xyloside was written by Wu, Xiubing;Kuang, Na;Chen, Langqiu;Fan, Yulin;Fu, Fang;Li, Jiping;Zhang, Jing. And the article was included in Journal of Molecular Liquids in 2020.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

Due to the inherent defects of the long alkyl chain in the related hydrophilicity and water solubility, alkyl α-D-xylosides (7) had hardly the practical application as sugar-based surfactants and should be reconstructed to obtain alkyl dioxyethyl α-D-xylosides (5) with dioxyethylene fragment (-(OCH₂CH₂)_2-) as the hydrophilic spacer to increase the related TPSA value. With D-xylose as the raw material, 1,2-cis alkyl dioxyethyl α-D-xylosides (5a-5f, n = 6-12) were stereoselectively synthesized. Their physicochem. properties including water solubility, surface tension, foamability, emulsification, thermotropic liquid crystal, and hygroscopicity had been investigated. Their water solubility was found to decrease gradually whereas their calculated HLB numbers were 14.72 → 11.67 (n = 6 → 12) with increasing alkyl chain length (n). Dodecyl dioxyethyl α-D-xyloside (5f) had not water solubility because the HLB number was low. Furthermore, their CMC values decreased with increasing the alkyl chain length, and the CMC value of decyl dioxyethyl α-D-xyloside (5e) was as low as 9.21 x 10^-5 mol·L^-1. Octyl dioxyethyl α-D-xyloside (5c) had the lowest surface tension (27.25 mN·m^-1) at the CMC. Both of nonyl and decyl dioxyethyl α-D-xylosides (5d & 5e) possessed good foaming power and foam stability. Decyl dioxyethyl α-D-xyloside (5e) had the strongest emulsifying property either in the toluene/water system or in the octane/water system. Nonyl dioxyethyl α-D-xylosides (5d) had the most stylish SA texture. Hexyl dioxyethyl α-D-xyloside (5a) possessed the strongest hygroscopicity. Therefore, the alkyl dioxyethyl α-D-xylosides as a class of novel sugar-based surfactants will be widely considered as promising candidates for various practical applications. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C10H22O3

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Volatility by Design. Synthesis and Characterization of Polyether Adducts of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)barium and Their Implementation as Metal-Organic Chemical Vapor Deposition Precursors was written by Belot, John A.;Neumayer, Deborah A.;Reedy, Charles J.;Studebaker, Daniel B.;Hinds, Bruce J.;Stern, Charlotte L.;Marks, Tobin J.. And the article was included in Chemistry of Materials in 1997.Recommanded Product: 112-59-4 The following contents are mentioned in the article:

The synthesis and characterization of polyethers and volatile, low-melting polyether complexes of bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)barium Ba(hfa)₂·RO(CH₂CH₂O)_nR’ where R = R’ = Me, n = 3; R = Me, R’ = Et, n = 3; R = R’ = H, n = 5, 6; R = R’ = Me, n = 4; R = Me, R’ = Et, n = 5; R = Me, R’ = Bu, n = 5, 6; R = Me, R = C₅H₁₁O, n = 3; R = Me, R’ = n-C₆H₁₃, n = 4, 5; R = Et, R’ = Bu, n = 5; R = Bu, R’ = Bu, n = 4, 6; R = Bu, R’ = n-C₆H₁₃, n = 5 are reported. The complexes are conveniently synthesized by reaction of n-propylammonium⁺hfa^– in DMF with an aqueous solution of Ba(NO₃)₂ and the polyether or, alternatively, by reaction of the polyether with Ba(hfa)₂ in toluene. These new complexes were characterized by elemental anal., FTIR, ¹H, ¹³C, and ¹⁹F NMR, MS, x-ray diffraction (Ba(hfa)₂·CH₃O(CH₂CH₂O)₃CH₃·H₂O, Ba(hfa)₂·CH₃O(CH₂CH₂O)₅C₂H₅), and TGA. The m.ps. of the complexes are strongly dependent on the architecture of the polyether chain and dimensions of the terminal polyether substituent, with the lowest m.ps. corresponding to the longest polyethers having the largest terminal groups. The volatility of the Ba(hfa)₂·polyether compounds is dependent on mol. weight and mol. structure; however, there is little direct correlation between m.p. depression and enhanced volatility. The applicability of these complexes in metal-organic CVD is demonstrated by the successful growth of phase-pure BaTiO₃ thin films using Ba(hfa)₂·CH₃O(CH₂CH₂O)₅C₂H₅ as the Ba source. Phase composition and epitaxy in these films is analyzed by energy-dispersive x-ray spectroscopy and x-ray diffraction Θ-2Θ, ω, and φ scans. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Recommanded Product: 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of Molecular Structure on Wetting Behavior at the Air-Liquid Interface of Water + Alcohol Mixtures was written by Yeh, Ming-Chih;Lin, Ping-Chang;Chen, Li-Jen. And the article was included in Journal of Physical Chemistry B in 2004.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

In this study, the wetting behavior of binary water + alc. mixtures was carefully investigated by using eight different short-chain alcs. These binary mixtures exhibit liquid-liquid equilibrium over the exptl. temperature range 10∼40 °C. The wetting behavior of the upper liquid (alc.-rich) phase at the surface of the lower liquid (aqueous) phase can be determined according to the wetting coefficient resulting from the interfacial tension measurements. Mol. structure of alcs. plays an essential role in the wetting behavior. The purpose of this study is threefold. (1) The effect of the hydrocarbon chain length of alcs. was examined by employing water + 1-butanol (C₄E₀), water + 1-pentanol (C₅E₀), and water + 1-hexanol (C₆E₀) three systems, where C_iE_j is the abbreviation of a nonionic polyoxyethylene alc. C_iH_2i+1(OCH₂CH₂)_jOH. The shorter chain alc. has a stronger tendency to wet the surface of the aqueous phase. (2) The effect of number of oxyethylene groups of alcs. was investigated by using three mixtures, water + C₆E₀, water + C₆E₁, and water + C₆E₂. An interfacial phase transition from partial wetting to nonwetting was observed for water + C₆E_j mixtures as the number of oxyethylene groups j increases from 1 to 2. (3) The effect of isomeric structures of alcs. on wetting behavior was investigated by studying three mixtures, water + 1-pentanol, water + 2-pentanol (2-C₅E₀), and water + tert-pentanol (t-C₅E₀). An interfacial phase transition from partial wetting to complete wetting occurs while the mol. structure of alcs. evolves from linear (C₅E₀) to near spherical (t-C₅E₀) shape. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
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Water-soluble phosphorus porphyrins with high activity for visible light-assisted inactivation of Saccharomyces cerevisiae was written by Matsumoto, Jin;Shinbara, Tomohiko;Tanimura, Shin-ichiro;Matsumoto, Tomoko;Shiragami, Tsutomu;Yokoi, Haruhiko;Nosaka, Yoshio;Okazaki, Shigetoshi;Hirakawa, Kazutaka;Yasuda, Masahide. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2011.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

In an effort to develop water-soluble singlet-oxygen (¹O₂) photosensitizer, we synthesized a series of phosphorus porphyrin complexes (1, (RO)₂P(tpp)⁺Cl^–, tpp = tetraphenylporphyrinato ligand, R = -(CH₂CH₂O)_m-(CH₂)_n-H, m = 0-3, n = 1, 2, 4, 6) and evaluated their performance characteristics. Water-solubilities of 1 (m = 1, 2 and n = 1, 2, 4, 6) were determined to be >1.0 mM, which was higher than the parent (HO)₂P(tpp)⁺Cl^–. The quantum yields for the generation of ¹O₂ in water based on the amount of ¹ 1* were determined to be 0.73, 0.69, and 0.62 for 1d (m = 2, n = 4), 1e (m = 2, n = 2), and 1f (m = 2, n = 1), resp. Photo-inactivation by 1 was performed with yeast (Saccharomyces cerevisiae), and was evaluated using a inactivation factor A _F = ([1]_M × T _1/2)^-1, where [1]_M is the min. effective concentration of 1 and T _1/2 is a half-life of the yeast initially used. In the case of 1b (m = 1, n = 6) and 1c (m = 2, n = 6), [1]_M was determined to be 5 nM in the photo-sterilization. Bio-affinity was evaluated by the adsorbed concentration of 1 ([P]_ad) into the yeast, which was measured by absorption spectrophotometry using a confocal laser-scanning microscope. These findings revealed that a large amount of 1 was adsorbed into the yeast. The estimated amount of 1b obtained from 10 μM aqueous solution came to 171 mM (17,100 fold) in terms of concentration As an increase in carbon number (n) of the alkyl group on axial ligands, A _F and [P]_ad increased. It is strongly suggested that the photo-inactivation took place with the assistance of the attack of ¹O₂ inside the cells. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem