Category: 112-59-4

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers was written by Grimm, Fabian A.;House, John S.;Wilson, Melinda R.;Sirenko, Oksana;Iwata, Yasuhiro;Wright, Fred A.;Ball, Nicholas;Rusyn, Ivan. And the article was included in Regulatory Toxicology and Pharmacology in 2019.Formula: C10H22O3 The following contents are mentioned in the article:

In this study, we apply a suite of organotypic and population-based in vitro models for comprehensive bioactivity profiling of twenty E-Series and P-Series glycol ethers, solvents with a broad variation in toxicity ranging from relatively non-toxic to reproductive and hematopoetic system toxicants. Both E-Series and P-Series glycol ethers elicited cytotoxicity only at high concentrations (mM range) in induced pluripotent stem cell-derived hepatocytes and cardiomyocytes. Population-variability assessment comprised a study of cytotoxicity in 94 human lymphoblast cell lines from 9 populations and revealed differences in inter-individual variability across glycol ethers, but did not indicate population-specific effects. Data derived from various phenotypic and transcriptomic assays revealed consistent bioactivity trends between both cardiomyocytes and hepatocytes, indicating a more universal, rather than cell-type specific mode-of-action for the tested glycol ethers in vitro. In vitro bioactivity-based similarity assessment using Toxicol. Priority Index (ToxPi) showed that glycol ethers group according to their alc. chain length, longer chains were associated with increased bioactivity. While overall in vitro bioactivity profiles did not correlate with in vivo toxicity data on glycol ethers, in vitro bioactivity of E-series glycol ethers were indicative of and correlated with in vivo irritation scores. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Formula: C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C10H22O3

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Fish-shaped diagram of liquid-liquid equilibria for the mixtures water + n-alkane + n-alkyl polyglycol ether was written by Matsuda, Hiroyuki;Nakazato, Yuki;Tsuchiya, Rei;Inoue, Yoshihiro;Kurihara, Kiyofumi;Tsuji, Tomoya;Tochigi, Katsumi;Ochi, Kenji. And the article was included in Fluid Phase Equilibria in 2022.HPLC of Formula: 112-59-4 The following contents are mentioned in the article:

The aim of this work is to determine the fish-shaped diagram of liquid-liquid equilibrium (LLE) of ternary mixtures of water + n-alkane + n-alkyl polyglycol ether (C_iE_j) using a cloud point method with laser scattering technique. n-Octane and n-dodecane were selected as the n-alkanes, and 2-butoxyethanol (C₄E₁) and 2-(2-hexyloxyethoxy)ethanol (C₆E₂) were selected as the n-alkyl polyglycol ethers. In the measurements of the ternary mixtures, the C_iE_j free basis mass fraction “α” of n-alkane was changed from 0.1 to 0.9. The exptl. fish-shaped diagrams were evaluated by comparing the exptl. cloud point data with the fish-shaped diagrams as well as the phase boundaries of tie-line and tie-triangle data in the mixtures of water + n-octane + C₄E₁ and water + n-dodecane + C₆E₂ reported in the literature. X-points where the fish body and fish tail intersect were determined from the exptl. cloud points, as well as the upper and lower critical point temperature of the fish-body. Changes in the phase diagram and X-points with different n-alkanes, C_iE_j, and the value of α were analyzed using the exptl. data. The LLE data of the mixture of water + C₆E₂, as one of the binary components of the ternary mixture, was also measured. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4HPLC of Formula: 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 112-59-4

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Cleaning properties of single-phase hydrocarbon-based microemulsion systems was written by Klier, J.;Suarez, R. S.;Green, D. P.;Kumar, A. M.;Hoffman, M.;Tucker, C. J.;Landes, B.;Redwine, D.. And the article was included in Journal of the American Oil Chemists’ Society in 1997.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Single-phase hydrocarbon-based microemulsions with low volatile organic carbon levels were evaluated in terms of solvent-like cleaning properties, and can help meet regulatory requirements. The rheol. and petroleum jelly solubilization properties of model microemulsion systems that contained linear alkylbenzenesulfonate surfactant, diethylene glycol monohexyl ether co-surfactant, and equal volumes of hydrocarbon solvent and water were evaluated as a function of microemulsion structure and composition The hydrocarbons were linear alkanes C₅ to ₁₂. Single-phase microemulsions with low surfactant contents and broad formulation flexibility were obtained through the use of efficient anionic surfactants and low NaCl electrolyte levels. The microemulsion structure was advanced from solvent-continuous to water-continuous by varying the solvent alkane carbon number or the electrolyte content, whereas the liquid crystal content was controlled via cosurfactant concentration Both microemulsion structure and viscosity influenced solubilization rates. Low-viscosity, solvent-continuous microemulsions showed solubilization rates comparable to those found with solvent-based systems, while water-continuous microemulsions showed relatively poor solubilization rates. Microemulsions containing dispersed liquid crystals exhibited high viscosity and low solubilization rates. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C10H22O3

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Water Solubility and Surface Property of Alkyl Di-/Tri-/Tetraoxyethyl β-D-Xylopyranosides was written by Wu, Xiubing;Chen, Langqiu;Fan, Yulin;Fu, Fang;Li, Jiping;Zhang, Jing. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides as derivatives of alkyl xylosides are a class of non-ionic sugar-based surfactants. They were stereoselectively synthesized by the Helferich method. Their properties including hydrophilic-lipophilic balance number, water solubility, surface property, foam property, emulsifying property, and thermotropic liquid crystal property were mainly investigated. The results showed that their water solubility decreased with increasing the alkyl chain length and increasing the number of the oligooxyethyl fragment. The critical micelle concentration had a monotonous decreasing trend with increasing the alkyl chain length. Nonyl di-/tri-/tetraoxyethyl β-D-xylopyranosides [-(OCH₂CH₂)_m-, where m = 2, 3, and 4] exhibited the most excellent foaming ability and foam stability. In the n-octane/water system, dodecyl tetraoxyethyl β-D-xylopyranosides and tetradecyl tetraoxyethyl β-D-xylopyranosides had the strongest emulsion ability. In addition, some alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides had thermotropic liquid crystal properties. Such sugar-based surfactants, alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides, will be expected to develop for a variety of practical application. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H22O3

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Morphologies of three-phase emulsions of the ternary nonionic amphiphile/oil/water systems and their determination by electrical method was written by Lee, Jong-Moon;Shin, Hong-Ju;Lim, Kyung-Hee. And the article was included in Journal of Colloid and Interface Science in 2003.Electric Literature of C10H22O3 The following contents are mentioned in the article:

Equations were developed for the elec. and thermal conductivities of dispersions of 2 different phases of low conductivity in a 3rd, conductive phase. These equations predict the conductivity of the dispersion from the volume fractions and conductivities of the constituent phases. Elec. conductivity measurements on dispersions of 3 liquid phases, i.e., 3-phase emulsions, were made over a wide range of volume fractions of each dispersed phase and used to test the equations. The equations predict accurately dispersion conductivities from the measured volume fractions and conductivities of the constituent phases without any adjustable parameters. The predicted values are in excellent agreement with the measured conductivities of 3-phase emulsions in the nonionic amphiphile/oil/H₂O systems. This leads to the determination of 3-phase emulsion morphologies. When the ratio K_d of the emulsion-drop conductivity to the continuous phase conductivity is O(10^-1)<K_d<1, the elec. method yields the correct morphol. When K_d≪1, the equations predicted several morphologies, but the correct morphol. can be chosen when the data are supplemented by another method such as microscopy. The elec. method, which is a combination of conductivity measurements and their fits to the equations, was proven to be effective and reliable in determination of 3-phase dispersion morphologies. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Electric Literature of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C10H22O3

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TOC removal of diethylene glycol mono-n-hexyl ether synthetic wastewater and 1,4-butanediol diglycidyl ether synthetic wastewater with H₂O₂/UV in a batch reactor was written by Hou, Wei-Jie;Tsuneda, Satoshi;Hirata, Akira. And the article was included in Journal of Chemical Engineering of Japan in 2001.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Removal of diethylene glycol mono-n-hexyl ether (DGME) or 1,4-butanediol diglycidyl ether (BDE) from wastewater by H₂O₂/UV was studied. Experiments were carried out in a batch reactor with a low pressure UV lamp (500 W) irradiating UV at 254 nm and at 185 nm (5% of energy). Complete TOC removals were obtained. TOC removals were pseudo-1st-order processes. The removal rates of TOC were governed by the concentration of H₂O₂ added initially and the maximum pseudo-1st-order rate constant and the optimum initial H₂O₂ concentration existed both in the wastewater. The relation between the initial TOC concentration and the optimum initial H₂O₂ concentration exhibited linear in both wastewaters. The optimum initial H₂O₂ concentration in the TOC removal of the BDE wastewater is higher than that of the DGME wastewater at a given initial TOC concentration The maximum pseudo-1st-order rate constant increases with the decrease in the initial TOC concentration in both wastewaters. The maximum pseudo-1st-order rate constant for the DGME wastewater is higher than that for the BDE wastewater at a given initial TOC concentration The exptl. results agree well with the theor. consideration which has been previously proposed by authors when H₂O₂ and TOC concentrations in the wastewater were very high. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Category: ethers-buliding-blocks).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: ethers-buliding-blocks

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Solid State Inclusion of the Nonionic Surfactant C₁₂E₄ in β-Cyclodextrin, at Various Humidities: A Combined Raman and ¹³C CP MAS NMR Study was written by Cunha-Silva, Luis;Teixeira-Dias, Jose J. C.. And the article was included in Journal of Physical Chemistry B in 2002.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

The inclusion of the nonionic surfactant α-n-dodecyl-ω-hydroxytetra(oxyethylene), C₁₂E₄, in β-cyclodextrin (β-CD), was prepared in the solid state and its structure characterized by powder x-ray diffraction, thermogravimetry, and Raman and ¹³C CP/MAS NMR spectroscopies. Stepwise dehydration was observed in the thermogram, indicating the presence of energetically distinct water mols. Comparison of the dispersions of ¹³C chem. shift values for C1 and C4 atoms of the β-CD macrocycle, within a series of inclusion compounds of C_nE_m homologues, reveals a rather complete symmetrization of the β-CD macrocycle, and the dispersions of ¹³C shifts for C6 atoms point to the particular sensitivity of these atoms to hydrogen-bonding type of interactions. The integrated intensity of the O-H Raman stretching band for the β-CD inclusion compound of C₁₂E₄ is approx. constant for humidities between 20% and 80%. In passing from 15% to 20% of humidity, one observes abrupt relative intensity variations of some Raman bands, in particular at 926 cm^-1, and the sudden decrease of the dispersions of ¹³C chem. shift values for all carbon atoms of the β-CD macrocycle. Overall, the above findings converge to stress the structural relevance of hydration water in the β-CD inclusion compound of C₁₂E₄. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C10H22O3

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Columnar Liquid-Crystalline Metallomacrocycles was written by Kawano, Shin-ichiro;Ishida, Yukari;Tanaka, Kentaro. And the article was included in Journal of the American Chemical Society in 2015.Computed Properties of C10H22O3 The following contents are mentioned in the article:

The authors report synthesis of novel macrocyclic mols. and their metal complexes as well as their thermotropic columnar liquid-crystalline behavior. The macrocyclic ligands were prepared size-selectively based on dynamic covalent chem. X-ray study of a model macrocycle with short alkyl chains revealed that they were discrete and highly sym., with an inner vacant cavity of 9 Å diameter enclosed by a 56π planar ring composed of four bis(salicylidene)-o-phenylenediamine (salphen) moieties alternating with four carbazoles. Ni²⁺ and Cu²⁺ ions were incorporated into the four salphen ligands and formed square-planar metal complexes inside the macrocycles. From the structural and thermal analyses via x-ray diffraction measurements, DSC, and polarized optical-microscopic observations, the macrocyclic ligand and its metal complexes self-assembled into columnar liquid-crystalline phases depending on the temperature and displayed a highly fluid character over a wide range of temperatures The peripheral alkyl chains were influential in controlling the temperature range and flowability of the liquid-crystalline phases, and the range of the liquid-crystalline temperature of the metallo-macrocycles was significantly higher than those of the metal-free macrocycles. To the best of the authors’ knowledge, these are the first examples of thermotropic columnar liquid crystals of macrocyclic metal complexes with a large hollow area. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C10H22O3

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Ultralow interfacial tensions in water-n-alkane-surfactant systems was written by Sottmann, T.;Strey, R.. And the article was included in Journal of Chemical Physics in 1997.Recommanded Product: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The interfacial tensions between water- and oil-rich phases in the presence of microemulsions have been measured for ternary systems of water, n-alkanes, and nonionic alkylpolyglycolether surfactants (C_iE_j). It is found that the min. of the interfacial tension curve, which is observed for each system in conjunction with the well-known phenomenon of phase inversion, depends sensitively, but systematically, on the chem. nature of the oil and the surfactant. Specifically, the min. value of the interfacial tension σ̅_ab decreases by 1 order of magnitude on decreasing either the carbon number of the alkane k by 6, or the number of oxyethylene groups j by 3, or by increasing the number of carbon atoms in the surfactant tail i by 2. The numerical values of the interfacial tensions as a function of temperature are presented along with an empirical description previously suggested. From the anal., in terms of bending energy one obtains estimates for the bending and saddle-splay constants The similar shape of the interfacial tension curves permits a superposition of the data for all 19 systems in support of a scaling relation recently derived (Leitao, S. et al., 1996). Furthermore, we note a striking coincidence of the numerical values of critical amplitude ratio R = σ₀ξ₀² = 0.37 kT in near-critical systems and the product σ̅_abξ̅² = 0.44(±0.10) kT where ξ̅ is the maximum length scale in the bicontinuous microemulsions. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Recommanded Product: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2-(2-(Hexyloxy)ethoxy)ethanol

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Separation of Glycol Ethers and Similar LCST-Type Hydrogen-Bonding Organics from Aqueous Solution Using Distillation or Liquid-Liquid Extraction was written by Frank, Timothy C.;Donate, Felipe A.;Merenov, Andrei S.;Von Wald, Grant A.;Alstad, Barbara J.;Green, Christian W.;Thyne, Thomas C.. And the article was included in Industrial & Engineering Chemistry Research in 2007.Product Details of 112-59-4 The following contents are mentioned in the article:

Infinite-dilution relative volatility (α^∞_i.water) was measured at 50° and 80° using a Rayleigh distillation apparatus for dilute solutions of propylene glycol Bu ether (PnB), propylene glycol Pr ether (PnP), and dipropylene glycol Bu ether (DPnB) dissolved in water and brine (3% NaCl). The data were analyzed to determine infinite-dilution activity coefficient (γ^∞_i,aqueous), Henry’s Law constant, partial molar enthalpy of mixing, and Setschenow constant Partition ratio (K) for extraction of PnP was also measured using 14 hydrophobic organic extraction solvents, including alcs., ketones, ethers, chlorinated hydrocarbons, aromatics, and aliphatics. An interpretation of mol. interactions in solution is given based on the anal. of activity coefficients, as a function of temperature and salt concentration General rules are proposed for the class of hydrogen-bonding organic compounds characterized by the presence of a lower critical solution temperature (LCST) in the organic + water phase diagram. The α_i,water is likely to increase as the temperature increases for stripping volatile LCST-type hydrogen-bonding organics from dilute aqueous solution, provided the pure-component vapor pressure relative to water (p^SAT_i/p^SAT_water) also increases or stays approx. the same. For extraction of LCST-type compounds from aqueous solution, K is likely to increase as the temperature increases, provided that the mutual solubility between phases is low. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Product Details of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 112-59-4

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