Category: 111-90-0

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Sawale, Sunil Rambhau;Shete, R. V.;Bhagat, Vishwas C.;Deshmukh, Madhuri T. research published 《 Nanostuctured lipid based drug delivery system of lopinavir- optimization and evaluation》, the research content is summarized as follows. By using the high-shear homogenization method Nanostructured lipid carriers (NLCs) loaded with lopinavir (LOP) were prepared The LOPNLCs formulations were freeze-dried using POLOXOMER 188 as a cryoprotectant. A burst release is shown by in vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The optimized freeze-dried formulation (LOP-NLC) had a particle size (PS), zeta potential (ZP) and % entrapment efficiency (%EE) of 159.5 _ 3.75 nm, 0.413 _ 0.017, -46 mV and 97.77 _ 4.46%, resp. A spherical shape was observed in the optimized formulation by transmission and scanning electron microscopes. The absence of chem. interaction between the drug and lipids is observed in Differential scanning Calorimetry study. In vitro study is performed using the bulk-equilibrium reverse dialysis technique, to investigate LOP release from optimized LOP-NLC and pure drug suspension in different media. The optimized formulations stored in amber glass container were found to be phys. and chem. stable for three months at room temperature The bioavailability of LOP following oral administration of LOP-NLC in male Wistar rats was found 4.52-fold higher than the LOP-suspension. So the conclusion is:- for improving the oral bioavailability of lopinavir, the nanostructure lipid carriers are potential carriers.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Computed Properties of 111-90-0.

Sayed, Mohammed A.;Saini, Rajesh K.;AlAli, Eyad;Kalgaonkar, Rajendra;Arnous, Ahmed research published 《 Safer Dual-Functional Gas Hydrate Dissolver and Inhibitor to Replace Methanol》, the research content is summarized as follows. In the presence of free water and under certain conditions of temperature and pressure, low-mol.-weight gases such as methane and ethane present in the fluid stream flowing in pipelines cause the formation of gas hydrate crystals. These gas hydrate crystals may accumulate and cause a partial or complete plugging of pipelines in the vertical or horizontal section. Methanol has been used in the industry as an effective gas hydrate dissolver and inhibitor, but its low flashpoint temperature makes it unsafe to be stored and pumped in large volumes The objective of the current work is to develop a safer dissolver and inhibitor for gas hydrate plugs that form in pipelines. Methanol has a very low f.p. (-90°C) and it is completely miscible with water, which can shift the hydrate phase equilibrium to lower temperatures Solvent- and aqueous-based formulations were selected as alternatives to methanol, keeping in mind parameters such as higher flashpoint, miscibility with water, f.p., viscosity, and local availability. The performance of these formulations was evaluated in a see-through gas hydrate reactor. Representative gas and water compositions were used in the experiments to form the gas hydrate inside the reactor. Hydrate formation was detected by the change in torque or by visual inspection through the see-through window of the reactor. Methanol was able to mobilize the hydrate plug when used at 10 vol %, while complete dissolution was achieved at 30 vol %. In comparison, the potassium formate saturated solution achieved complete dissolution of the hydrate plugs at 10 vol % in a lesser time compared to methanol. The tested formulations worked not only as a dissolver but also as an inhibitor to prevent the formation of hydrates once they are melted or dissolved. These formulations enable safer operations in the field and improve the performance when it comes to melting gas hydrate plugs.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Computed Properties of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Reference of 111-90-0.

Rahimpour, Elaheh;Acree, William E. Jr.;Jouyban, Abolghasem research published 《 Prediction of sulfonamides’ solubilities in the mixed solvents using solvation parameters》, the research content is summarized as follows. The exptl. solubility data of various sulfonamides in the binary solvent systems at various temperatures are collected from the literature and fitted to Jouyban-Acree model as an accurate cosolvency model for providing solubility prediction tools. In order to obtain predictive cosolvency models, the Jouyban-Acree model is combined with physicochem. parameters of the Abraham solvation parameters and the Hansen solubility parameters. Based on these computations, the generally trained versions of the combined models are proposed which enable one to predict the solubility of sulfonamides in the binary solvent mixtures at various temperatures with reasonable error levels.

Reference of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Related Products of 111-90-0.

Rahimpour, Elaheh;Alvani-Alamdari, Sima;Acree, Jr. William E.;Jouyban, Abolghasem research published 《 Drug Solubility Correlation Using the Jouyban-Acree Model: Effects of Concentration Units and Error Criteria》, the research content is summarized as follows. An important factor affecting the model accuracy is the unit expression type for solute and solvent concentrations One can report the solute and solvent concentration in various units and compare them with various error scales. In order to investigate the unit and error scale expression effects on the accuracy of the Jouyban-Acree model, in the current study, seventy-nine solubility data sets were collected randomly from the published articles and solute and solvent concentrations in the investigated systems were expressed in various units. Mass fraction, mole fraction, and volume fraction were the employed concentration units for the solvent compositions, and mole fraction, molar, and gram/L were the investigated concentration units for the solutes. The solubility data, with various solute/solvent concentration units, were correlated using the Jouyban-Acree model, and the accuracy of each model for correlating the data was investigated by calculating different error scales and discussed.

Related Products of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 111-90-0.

Rajamma, Sreeranjini Sukumaran;Krishnaswami, Venkateshwaran;Prabu, Sakthivel Lakshmana;Kandasamy, Ruckmani research published 《 Geophila repens phytosome-loaded intranasal gel with improved nasal permeation for the effective treatment of Alzheimer′s disease》, the research content is summarized as follows. Geophila repens (L.) I. M. Johnst is a creeping herb with good anti-cholinesterase activity and has been used traditionally in India to improve memory and intelligence for many years. The antioxidant activity of the ′methanolic extract of the leaves of Geophila repens′ (MEGR) was determined and found to be high, possibly due to the presence of phenolic compounds, flavonoids, and triterpenoids. The permeation of phytoconstituents through the blood-brain barrier is a challenging factor in the development of phytoformulation for the treatment of Alzheimer′s disease (AD). To overcome these limitations, ′Geophila repens phytosome-loaded intranasal gel′ (MEGR-PG) with enhanced permeation properties through the nasal route to the brain was developed. Here, transcutol was used as permeation enhancer and hydroxypropyl methylcellulose as a gelling agent. For the development of MEGR-PG, a screened phytosome (MEGR: soy phosphatidylcholine, 1: 2) with a particle size of 444.93 ± 25.24 nm, PDI value of 0.358 ± 0.012, spherical morphol., encapsulation efficiency of 51.88 ± 1.025% with an immediate in vitro release of 45.84 ± 5.6% at 60 min followed by a maintenance period of up to 480 min was used. MEGR-PG exhibited significant in vitro nasal mucosa permeation without causing skin irritation. Furthermore, MEGR-PG exhibited a similar proportion of acetylcholinesterase inhibition (97.87 ± 6.84%) in comparison to donepezil (97.17 ± 4.86%) but was greater than MEGR (69.86 ± 5.68%), and it also accelerated angiogenesis, which shows potential to modify the cognitive behavior of AD patients. In addition, the brain targeting effect of MEGR-PG has been confirmed by a preclin. in vivo imaging study. As a result, MEGR-PG is a promising treatment option for AD patients.

Computed Properties of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C6H14O3.

Raju, Marina;Kunde, Shalvi Sinai;Auti, Sandip T.;Kulkarni, Yogesh A.;Wairkar, Sarika research published 《 Berberine loaded nanostructured lipid carrier for Alzheimer’s disease: Design, statistical optimization and enhanced in vivo performance》, the research content is summarized as follows. Berberine, an isoquinoline alkaloid, is reported for the treatment of Alzheimer’s disease. Despite having substantial therapeutic potential, it exhibits poor absorption, low oral bioavailability and limited penetration in the brain. In this study, berberine-loaded nanostructured lipid carriers (Berb-NLCs) were developed by melt-emulsification and ultrasonication using Geleol, Miglyol 812 N, Solutol HS 15 as a solid lipid, liquid lipid and surfactant, resp. The Berb-NLC formulation was statistically optimized by a 32 factorial design in which the effect of surfactant and berberine concentration was assessed on particle size and entrapment efficiency of Berb-NLCs. Optimized Berb-NLCs (Trial-5) exhibited particle size of 186 nm, polydispersity index of 0.108, the zeta potential of -36.86 mV and 88% entrapment efficiency. The in vitro release of berberine from Batch-B5 was 82% in phosphate buffer at the end of 24 h. The comparative results of pharmacodynamic studies involving behavioral assessment by locomotor activity, passive avoidance test, elevated plus maze test and spatial memory assessment by Morris water maze demonstrated improved behavioral parameters in vivo by Berb-NLCs compared to pure berberine in Albino Wistar rats. Thus, berberine-loaded nanostructured lipid carriers have the potential of brain targeting and were effective in an animal model of Alzheimer’s disease.

COA of Formula: C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. HPLC of Formula: 111-90-0.

Ramanunny, Arya Kadukkattil;Wadhwa, Sheetu;Gulati, Monica;Gupta, Saurabh;Porwal, Omji;Jha, Niraj Kumar;Gupta, Piyush Kumar;Kumar, Deepak;Prasher, Parteek;Dua, Kamal;Saqr, Ahmed Al;Almawash, Saud;Singh, Sachin Kumar research published 《 Development and validation of RP-HPLC method for 1′-Acetoxychavicol acetate (ACA) and its application in optimizing the yield of ACA during its isolation from Alpinia galanga extract as well as its quantification in nanoemulsion》, the research content is summarized as follows. An isocratic RP-HPLC was developed and validated for isolation of 1′-Acetoxychavicol acetate (ACA) from Alpinia galanga extract (AGE). Nucleodur C18 column was used as the stationary phase and mixture of acetonitrile/0.1% formic acid in water (60/40, volume/volume) were used as mobile phase. The elution was carried out with a flow rate of 1 mL/min. Further, the method was validated as per ICH Q2 [R1] guidelines in terms of linearity, LOD, LOQ, recovery, precision and specificity. The validated method was utilized for two purposes i.e. optimizing the isolation of ACA from AGE and quantifying ACA′s concentration and release from its nanoemulsion. To achieve high yield of ACA, Central composite design (CCD) was used to optimize sieve number and solid to solvent ratio. The retention time of standard and isolated ACA were found at 5.63 min and 5.46 min resp. The results indicated that the validated method was linear, accurate, precise and specific. During optimization, excellent correlation was observed between practical yield (3.89 ± 0.23% weight/weight of dried rhizomes) and predicted yield (3.73% weight/weight of dried rhizomes) of ACA with p value more than 0.05. The percentage of ACA loaded in the nanoemulsion was found to be 99.12 ± 0.39. The in vitro diffusion studies showed 90.12 ± 2.21% release of ACA at the end of 24 h. It was concluded that the validated method has been successfully utilized to isolate the ACA from AGE and quantify the amount of ACA present in nanoemulsion.

HPLC of Formula: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. SDS of cas: 111-90-0.

Rezaei, Hadis;Rezaei, Homa;Rahimpour, Elaheh;Martinez, Fleming;Zhao, Hongkun;Jouyban, Abolghasem research published 《 Solubility profile of phenytoin in the mixture of carbitol and water at different temperatures》, the research content is summarized as follows. In this study, solubility profile of phenytoin in carbitol and water mixtures at 298.2-313.2 K is measured and some linear and non-linear cosolvency models are used to numerical representation of these data. The prediction capability of used models is investigated using training the models with min. possible data. The accuracy of applied models is checked by the calculation of the mean relative deviations (MRD %). Apparent thermodn. dissolution quantities were calculated based on van’t Hoff and Gibbs equations observing pos. Gibbs energies and enthalpies but neg. entropies. Addnl., phenytoin is preferentially solvated by water in water-rich mixtures but preferentially solvated by carbitol in the interval 0.12 < × 1 < 0.85 based on IKBI method.

SDS of cas: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application of C6H14O3.

Rezaei, Homa;Jouyban, Abolghasem;Zhao, Hongkun;Martinez, Fleming;Rahimpour, Elaheh research published 《 Solubility of caffeine in N-methyl-2-pyrrolidone + 1-propanol mixtures at different temperatures》, the research content is summarized as follows. Solubility data of pharmaceutical ingredients is required for crystallization, extraction and purification processes. The solubility profile and thermodn. modeling of caffeine in the binary non-aqueous mixed solutions of N-methyl-2-pyrrolidone (NMP) and 1-propanol at various temperatures ranging from 293.2 to 313.2 K are measured in this study using a shake-flask method and the obtained data are fitted to some linear and a non-linear math. cosolvency models. Furthermore, the densities of caffeine saturated solutions are also determined and correlated with an adopted version of the Jouyban-Acree model. To study the accuracy of the applied models, the mean relative deviations of the back-calculated solubility and d. data are computed. As well, the apparent thermodn. properties of the caffeine dissolution process in the mixed solutions of NMP and 1-propanol are also calculated by using van’t Hoff and Gibbs equations and discussed.

Application of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Category: ethers-buliding-blocks.

Romdhani, Asma;Osorio, Irmis P.;Martinez, Fleming;Jouyban, Abolghasem;Acree, William E. Jr research published 《 Further calculations on the solubility of trans-resveratrol in (Transcutol + water) mixtures》, the research content is summarized as follows. Ha et al. reported the equilibrium solubility of trans-resveratrol in some {Transcutol (1) + water (2)} mixtures at several temperatures with some numerical correlation and apparent dissolution thermodn. analyze. Nevertheless, no attempt was made to evaluate the effect of mixtures polarity on solubility nor preferential solvation of this compound by the solvent components. In this communication the effect of Hildebrand solubility parameters of mixtures on trans-resveratrol solubility was discussed. Moreover, the preferential solvation of trans-resveratrol in {Transcutol (1) + water (2)} mixtures at several temperatures was analyzed based on the inverse Kirkwood-Buff integrals as described in the literature. trans-resveratrol is preferentially solvated by water in water-rich mixtures (0.00 < x1 < 0.14) but preferentially solvated by Transcutol in mixtures with composition 0.14 < x1 < 1.00. These results could be interpreted as a consequence of hydrophobic hydration around the aromatic rings of the solute in the former case. The observed trend in the last case could be a consequence of the acid behavior of trans-resveratrol in front of Transcutol mols. because this cosolvent is more basic than water.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem