Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing was written by Sweilam, Mona N.;Cordery, Sarah F.;Totti, Stella;Velliou, Eirini G.;Campagnolo, Paola;Varcoe, John R.;Delgado-Charro, M. Begona;Crean, Carol. And the article was included in Biosensors & Bioelectronics in 2020.Product Details of 111-77-3 This article mentions the following:
Flexible wearable chem. sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chem. sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fiber-based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fiber-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Li+ from under porcine skin by applying a c.d. of 0.4 mA cm-2 via two electrodes. Carbon fiber-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fiber-based Li+ sensor and reference electrodes were capable of determining the Li+ concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatog. Addnl., biocompatibility of the materials used have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Product Details of 111-77-3).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Product Details of 111-77-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem