Category: 111-77-3

Iron-catalyzed oxidation of 1-phenylethanol and glycerol with hydrogen peroxide in water medium: effect of the nitrogen ligand on catalytic activity and selectivity was written by Ros, Dimitri;Gianferrara, Teresa;Crotti, Corrado;Farnetti, Erica. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The iron(II) complexes [Fe(bpy)₃](OTf)₂ (bpy = 2,2′-bipyridine; OTf = CF₃SO₃) (1) and [Fe(bpydeg)₃](OTf)₂ (bpydeg = N⁴,N⁴-bis(2-(2-methoxyethoxy)ethyl) [2,2′-bipyridine]-4,4′-dicarboxamide) (2), the latter being a newly synthesized ligand, were employed as catalyst precursors for the oxidation of 1-phenylethanol with hydrogen peroxide in water, using either microwave or conventional heating. With the same oxidant and medium the oxidation of glycerol was also explored in the presence of 1 and 2, as well as of two similar iron(II) complexes bearing tridentate ligands, i.e., [Fe(terpy)₂](OTf)₂ (terpy = 2, 6-di(2-pyridyl)pyridine) (3) and [Fe(bpa)₂](OTf)₂ (bpa = bis(2-pyridinylmethyl)amine) (4): in most reactions the major product formed was formic acid, although with careful tuning of the exptl. conditions significant amounts of dihydroxyacetone were obtained. Addition of heterocyclic amino acids (e.g., picolinic acid) increased the reaction yields of most catalytic reactions. The effect of such additives on the evolution of the catalyst precursors was studied by spectroscopic (NMR, UV-visible) and ESI-MS techniques. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Developing Eco-Friendly Skin Care Formulations with Microemulsions of Essential Oil was written by Lee, Sie Huey;Chow, Pui Shan;Yagnik, Chetan Kantilal. And the article was included in Cosmetics in 2022.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

With the rising public awareness of environmental issues, consumers are increasingly demanding skin care products that create less environmental impact but still provide the same or even greater efficacy. In the skin care arena, microemulsions have been receiving increased attention as the promising delivery technol. of skin care actives. Essential oils such as peppermint oil, lavender oil and eucalyptus oil are purported to have excellent antioxidant and antimicrobial properties that could be used as the eco-friendly alternatives for synthetic antioxidants and preservatives in the skin care formulations. This work therefore seeks to develop eco-friendly skin care formulations based on microemulsions of essential oil. Peppermint oil, lavender oil and eucalyptus oil were used as the oil phase to formulate naringin-loaded microemulsions, which demonstrated similar or better antioxidant and antimicrobial properties compared to the synthetic ones. When formulated into gel form, naringin-loaded microemulsion-gel formulations showed enhanced stability and release profile over their unformulated counterpart. Hence, microemulsions of essential oil developed in this work conferred a 4-fold benefits to the skin care formulations: (1) improved release (membrane permeation) of skin care active, (2) improved stability of skin care active, (3) as an eco-friendly alternative to synthetic antioxidant, and (4) a self-preserving system. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Extractive distillation of benzene, toluene, and xylenes from pyrolysis gasoline using methylsulfonylethane as a cosolvent was written by Gao, Siliang;Tang, Wencheng;Zhao, Ming;Qie, Siyuan;Pang, Weiwei;Tian, Longsheng. And the article was included in Asia-Pacific Journal of Chemical Engineering in 2021.Synthetic Route of C5H12O3 This article mentions the following:

Highly efficient separation of benzene, toluene, and xylenes (BTXs) from pyrolysis gasoline is very important in petrochem. industries. Though the extractive distillation (ED) process is simpler and consumes less energy compared with liquid-liquid extraction process, it is difficult for a single solvent, for example, sulfolane, to achieve both high purity and high yield of BTXs. In this work, methylsulfonylethane (MSE) was chosen as a cosolvent to improve the selectivity of sulfolane after solvent screening, and factors that may affect the selectivity of the composite solvent were fully investigated, such as the content of cosolvent, solvent to feed ratio, the composition of the feed, and temperature Furthermore, 240 h of continuous extractive distillation and solvent recovery experiment was carried out using sulfolane (85 wt%)-MES (15 wt%) mixture as solvent. The purity of mixed aromatics obtained was 99.83%, and the yield was as high as 99.7%. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Synthetic Route of C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Synthetic Route of C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor was written by Niu, Tian;Li, Kailin;Jiang, Li;Zhou, Zhesheng;Hong, Ju;Chen, Xuankun;Dong, Xiaowu;He, Qiaojun;Cao, Ji;Yang, Bo;Zhu, Cheng-Liang. And the article was included in European Journal of Medicinal Chemistry in 2022.Name: 2-(2-Methoxyethoxy)ethanol This article mentions the following:

Cyclin-dependent kinase 12 (CDK12) plays a crucial role in DNA-damage response gene transcription and has recently been validated as a promising target in cancer therapy. However, existing CDK12 inhibitors potently inhibit its closest isoform CDK13, which could cause potential toxicity. Therefore, the development of CDK12 inhibitors with isoform-selectivity against CDK13 continues to be a challenge. By taking advantage of the emerging PROteolysis-TArgeting Chimeras (PROTACs) approach, we have synthesized a potent PROTAC degrader PP-C8 based on the noncovalent dual inhibitors of CDK12/13 and demonstrated its specificity for CDK12 over CDK13. Notably, PP-C8 induces profound degradation of cyclin K simultaneously and downregulates the mRNA level of DNA-damage response genes. Global proteomics profiling revealed PP-C8 is highly selective toward CDK12-cyclin K complex. Importantly, PP-C8 demonstrates profound synergistic antiproliferative effects with PARP inhibitor in triple-neg. breast cancer (TNBC). The potent and selective CDK12 PROTAC degrader developed in this study could potentially be used to treat CDK12-dependent cancers as combination therapy. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Name: 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Visual monitoring of the lysosomal pH changes during autophagy with a red-emission fluorescent probe was written by Wang, Xiaodong;Fan, Li;Wang, Yubin;Zhang, Caihong;Liang, Wenting;Shuang, Shaomin;Dong, Chuan. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2020.Application of 111-77-3 This article mentions the following:

Autophagy plays crucial roles in maintaining normal intracellular homeostasis. Mol. probes capable of monitoring lysosomal pH changes during autophagy are still highly required yet challenging to develop. Here, a lysosome-targeting fluorescent pH probe, RML (I), is presented by introducing a methylcarbitol unit as the lysosome-targeting group to rhodamine B, which is highly sensitive to pH changes. RML exhibits remarkable pH-dependent behavior at 583 nm with a fluorescent enhancement of >148-fold. The pK_a value is determined as 4.96, and the linear response with pH changes from 4.50-5.70, which is favorable for lysosomal pH imaging. Also RML diffuses selectively into lysosomes using confocal fluorescence microscopy. Using RML, the authors have successfully visualized autophagy by monitoring the lysosomal pH changes. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Application of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemoinformatics-Driven Design of New Physical Solvents for Selective CO₂ Absorption was written by Orlov, Alexey A.;Demenko, Daryna Yu.;Bignaud, Charles;Valtz, Alain;Marcou, Gilles;Horvath, Dragos;Coquelet, Christophe;Varnek, Alexandre;de Meyer, Frederick. And the article was included in Environmental Science & Technology in 2021.Recommanded Product: 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The removal of CO₂ from gases is an important industrial process in the transition to a low-carbon economy. The use of selective phys. (co-)solvents is especially perspective in cases when the amount of CO₂ is large as it enables one to lower the energy requirements for solvent regeneration. However, only a few phys. solvents have found industrial application and the design of new ones can pave the way to more efficient gas treatment techniques. Exptl. screening of gas solubility is a labor-intensive process, and solubility modeling is a viable strategy to reduce the number of solvents subject to exptl. measurements. In this paper, a chemoinformatics-based modeling workflow was applied to build a predictive model for the solubility of CO₂ and four other industrially important gases (CO, CH₄, H₂, and N₂). A dataset containing solubilities of gases in 280 solvents was collected from literature sources and supplemented with the new data for six solvents measured in the present study. A modeling workflow based on the usage of several state-of-the-art machine learning algorithms was applied to establish quant. structure-solubility relationships. The best models were used to perform virtual screening of the industrially produced chems. It enabled the identification of compounds with high predicted CO₂ solubility and selectivity toward other gases. The prediction for one of the compounds, 4-methylmorpholine, was confirmed exptl. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Recommanded Product: 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photocontrolled Radical Polymerization from Hydridic C-H Bonds was written by Stache, Erin E.;Kottisch, Veronika;Fors, Brett P.. And the article was included in Journal of the American Chemical Society in 2020.Formula: C5H12O3 This article mentions the following:

Given the ubiquity of carbon-hydrogen bonds in biomols. and polymer backbones, the development of a photocontrolled polymerization selectively grafting from a C-H bond represents a powerful strategy for polymer conjugation. This approach would circumvent the need for complex synthetic pathways currently used to introduce functionality at a polymer chain end. On this basis, we developed a hydrogen-atom abstraction strategy that allows for a controlled polymerization selectively from a hydridic C-H bond using a benzophenone photocatalyst, a trithiocarbonate-derived disulfide, and visible light. We performed the polymerization from a variety of ethers, alkanes, unactivated C-H bonds, and alcs. Our method lends itself to photocontrol which has important implications for building advanced macromol. architectures. Finally, we demonstrate that we can graft polymer chains controllably from poly(ethylene glycol) showcasing the potential application of this method for controlled grafting from C-H bonds of commodity polymers. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cross-linked polyphosphazene blends as robust CO₂ separation membranes was written by Kusuma, Victor A.;McNally, Joshua S.;Baker, James S.;Tong, Zi;Zhu, Lingxiang;Orme, Christopher J.;Stewart, Frederick F.;Hopkinson, David P.. And the article was included in ACS Applied Materials & Interfaces in 2020.Formula: C5H12O3 This article mentions the following:

An effective crosslinking technique allows a viscous and highly gas-permeable hydrophilic polyphosphazene to be cast as solid membrane films. By judicious blending with other polyphosphazenes to improve the mech. properties, a membrane exhibiting the highest CO₂ permeability (610 barrer) among polyphosphazenes combined with a good CO₂/N₂ selectivity (35) was synthesized and described here. The material demonstrates performance stability after 500 h of exposure to a coal-fired power plant flue gas, making it attractive for use in carbon capture applications. Its CO₂/N₂ selectivity under conditions up to full humidity is also stable, and although the gas permeability does decline, the performance is fully recovered upon drying. The high mol. weight of these heteropolymers also allows them to be cast as a thin selective layer on an asym. porous membrane, yielding a CO₂ permeance of 1200 GPU and a CO₂/N₂ pure gas selectivity of 31, which does not decline over 2000 h. In addition to gas separation membranes, this cross-linked polyphosphazene can potentially be extended to other applications, such as drug delivery or proton exchange membranes, which take advantage of the polyphosphazene’s versatile chem. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Living and Alternating Cationic Copolymerization of o-Phthalaldehyde and Various Bulky Enol Ethers: Elucidation of the “Limit” of Polymerizable Monomers was written by Hayashi, Keisuke;Kanazawa, Arihiro;Aoshima, Sadahito. And the article was included in Macromolecules (Washington, DC, United States) in 2022.Reference of 111-77-3 This article mentions the following:

Cationic copolymerization of various bulky enol ethers, which have been difficult to homopolymerize and/or copolymerize, was shown to proceed when o-phthalaldehyde (OPA) was used as a comonomer. A series of enol ethers with various substituents on the β-carbon was synthesized from aliphatic aldehydes and alcs. The relationships between the structures of the enol ethers and the copolymerization behavior were systematically investigated. As a result, monomers with one or two Me and/or primary alkyl groups on the β-carbon were found to undergo alternating copolymerization with OPA. Moreover, living cationic copolymerization of enol ethers and OPA yielded alternating copolymers under appropriate polymerization conditions. To elucidate the limit of polymerizable monomers, the copolymerization of very bulky enol ethers such as β-t-butyl- or norbornenylidene-type monomers with OPA was also examined OPA was found to be copolymerizable even with such very bulky monomers, indicating that the unique reactivity of the OPA-derived propagating carbocation with small steric hindrance is the key factor for successful copolymerization In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Reference of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Reference of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Modeling hydrogen solubility in alcohols using machine learning models and equations of state was written by Mohammadi, Mohammad-Reza;Hadavimoghaddam, Fahimeh;Atashrouz, Saeid;Abedi, Ali;Hemmati-Sarapardeh, Abdolhossein;Mohaddespour, Ahmad. And the article was included in Journal of Molecular Liquids in 2022.HPLC of Formula: 111-77-3 This article mentions the following:

Knowledge of hydrogen (H₂) solubility in alcs. is important for designing and performing various processes in chem. plants. Accurate predictions of H₂ solubility in alcs. can affect the quality and applications of pharmaceuticals, perfume, cosmetics, flavor, and many others. In this work, deep echo state network (DeepESN), extreme gradient boosting (XGBoost), extreme learning machine (ELM), and multivariate adaptive regression splines (MARS) as four advanced machine learning models were utilized for predicting the H₂ solubility in alcs. To this end, a complete set of H₂ solubility data (673 exptl. data points) for 26 different alcs. or alc.-containing solvents is gathered over a wide range of operating pressure (0.101-110.3 MPa) and temperature (213.15-524.9 K). The XGBoost model was obtained as the best model for estimation H₂ solubility in alcs. based on graphical and statistical analyses having a root mean square error of 0.0022 and coefficient of determination of 0.9946. Four well-known equations of state (EOSs) were also utilized to estimate H₂ solubility in alcs., among which Redlich-Kwong EOS had the best performance. However, the accuracy of machine learning models was much higher than the EOSs. Based on sensitivity anal., pressure, temperature, and mol. weight of alcs. have the highest impact on the solubility of H₂ in alcs., resp. Eventually, the Leverage approach was utilized to recognize the applicability domain of the XGBoost model and probable outlier data, the results of which show that this model has high credit for estimating the solubility of H2 in alcs. The outcome of this study can help to design the hydrogenation process in chem. plants, and the XGBoost model can act as an efficient predictor for predicting H2 solubility in alcs. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3HPLC of Formula: 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.HPLC of Formula: 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem