Category: 109-85-3

Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer was written by Vezina-Dawod, Simon;Perreault, Martin;Guay, Louis-David;Gerber, Nicolas;Gobeil, Stephane;Biron, Eric. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

A novel tumor suppressing agent was discovered against PC-3 prostate cancer cells from the screening of a 1,4-benzodiazepin-3-one library. In this study, 96 highly diversified 2,4,5-trisubstituted 1,4-benzodiazepin-3-one derivatives were prepared by a two-step approach using sequential Ugi multicomponent reaction and simultaneous deprotection and cyclization to afford pure compounds bearing a wide variety of substituents. The most promising compound (I) showed a potent and selective antiproliferative activity against prostate cancer cell line PC-3 (GI₅₀ = 10.2μM), but had no effect on LNCAP, LAPC4 and DU145 cell lines. The compound was initially prepared as a mixture of two diastereomers and after their separation by HPLC, similar antiproliferative activities against PC-3 cells were observed for both diastereomers (2S,5S: GI₅₀ = 10.8μM and 2S,5R: GI₅₀ = 7.0μM). Addnl., both diastereomers showed comparable stability profiles after incubation with human liver microsomes. Finally, in vivo evaluation of the hit compound with the chick chorioallantoic membrane xenograft assay revealed a good toxicity profile and significant antitumor activity after i.v. injection. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Activities of quinoxaline, nitroquinoxaline, and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against Schistosoma mansoni was written by Debbert, Stefan L.;Hintz, Mikaela J.;Bell, Christian J.;Earl, Kenya R.;Forsythe, Grant E.;Haberli, Cecile;Keiser, Jennifer. And the article was included in Antimicrobial Agents and Chemotherapy in 2021.Quality Control of 2-Methoxyethylamine The following contents are mentioned in the article:

The reliance on one drug, praziquantel, to treat the parasitic disease schistosomiasis in millions of people a year shows the need to further develop a pipeline of new drugs to treat this disease. Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni. In this study, 47 synthesized compounds containing quinoxaline moieties were first assayed against the larval stage of this parasite, newly transformed schistosomula (NTS); of these, 16 killed over 70% NTS at 10 μM. Further testing against NTS and adult S. mansoni yielded three compounds with 50% inhibitory concentrations (IC₅₀s) of ≤0.31 μM against adult S. mansoni and selectivity indexes of ≥8.9. Administration of these compounds as a single oral dose of 400 mg/kg of body weight to S. mansoni-infected mice yielded only moderate worm burden reduction (WBR) (9.3% to 46.3%). The discrepancy between these compounds′ good in vitro activities and their poor in vivo activities indicates that optimization of their pharmacokinetic properties may yield compounds with greater bioavailabilities and better antischistosomiasis activities in vivo. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Quality Control of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Predicting relative efficiency of amide bond formation using multivariate linear regression was written by Haas, Brittany C.;Goetz, Adam E.;Bahamonde, Ana;McWilliams, J. Christopher;Sigman, Matthew S.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2022.Formula: C3H9NO The following contents are mentioned in the article:

Herein, the development of statistical models correlating measured rates to phys. organic descriptors to enable the prediction of reaction rates for untested carboxylic acid/amine pairs was reported. The key to the success of this endeavor was the development of an end-to-end data science-based work flow to select a set of coupling partners that were appropriately distributed in chem. space to facilitate statistical model development. By using a parameterization, dimensionality reduction, and clustering protocol, a training set was identified. Reaction rates for a range of carboxylic acid and primary alkyl amine couplings utilizing carbonyldiimidazole (CDI) as the coupling reagent were measured. The collected rates span five orders of magnitude, confirming that the designed training set encompasses a wide range of chem. space necessary for effective model development. Regressing these rates with high-level d. functional theory (DFT) descriptors allowed for identification of a statistical model wherein the mol. features of the carboxylic acid are primarily responsible for the observed rates. Finally, out-of-sample amide couplings are used to determine the limitations and effectiveness of the model. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CL^pro covalent inhibitors was written by Stille, Julia K.;Tjutrins, Jevgenijs;Wang, Guanyu;Venegas, Felipe A.;Hennecker, Christopher;Rueda, Andres M.;Sharon, Itai;Blaine, Nicole;Miron, Caitlin E.;Pinus, Sharon;Labarre, Anne;Plescia, Jessica;Burai Patrascu, Mihai;Zhang, Xiaocong;Wahba, Alexander S.;Vlaho, Danielle;Huot, Mitchell J.;Schmeing, T. Martin;Mittermaier, Anthony K.;Moitessier, Nicolas. And the article was included in European Journal of Medicinal Chemistry in 2022.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

Efforts in the design and synthesis of submicromolar covalent inhibitors when the enzymic activity of the viral protease was used as a screening platform were reported. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Visible light-promoted synthesis of ureas and formamides from amines and CO₂ was written by Zhang, Qian;Hou, Jing;Huang, Yan;Zhan, Le-wu;Li, Bin-dong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Synthetic Route of C3H9NO The following contents are mentioned in the article:

A divergent visible-light-induced Ph₃P-promoted method for the synthesis of ureas and formamides from amines and CO₂ is reported. Without external additions, a range of ureas could be directly accessed under ambient temperature and pressure. Using triisopropylsilanethiol as the hydrogen source, formamides could be produced. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

sp³ Bis-Organometallic Reagents via Catalytic 1,1-Difunctionalization of Unactivated Olefins was written by Sun, Shang-Zheng;Talavera, Laura;Spiess, Philipp;Day, Craig S.;Martin, Ruben. And the article was included in Angewandte Chemie, International Edition in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

A catalytic 1,1-difunctionalization of unactivated olefins en route to sp³ bis-organometallic B,B(Si)-reagents is described. The protocol is characterized by exceptional reaction rates, mild conditions, wide scope, and exquisite selectivity pattern, constituting a new platform to access sp³ bis-organometallics. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Using experimental and computational approaches to probe an unusual carbon-carbon bond cleavage observed in the synthesis of benzimidazole N-oxides was written by Politano, Fabrizio;Sandoval, Arturo Leon;Uranga, Jorge G.;Bujan, Elba I.;Leadbeater, Nicholas E.. And the article was included in Organic & Biomolecular Chemistry in 2021.HPLC of Formula: 109-85-3 The following contents are mentioned in the article:

Exptl. and computational studies was performed in order to investigate an unusual carbon-carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reaction was found to be the substituents on the amine functionality of the aniline. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3HPLC of Formula: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Comparing the anion binding of 4-amido- with 4-amino-1,8-naphthalimides was written by Filiti, Jacob;Hearn, Kyle;Rudebeck, Elley;Ngo, Huynh Thien;Pham-Tran, Nguyen-Nguyen;Pfeffer, Frederick. And the article was included in Organic & Biomolecular Chemistry in 2021.Application of 109-85-3 The following contents are mentioned in the article:

The synthesis and evaluation of a new anion receptor based on the 4-amido-1,8-naphthalimide scaffold is described. The findings indicate that the amide N-H is an enhanced H-bond donor but is otherwise restricted in its ability to participate in the binding of simple anions. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Site-Selective Defluorinative sp³ C-H Alkylation of Secondary Amides was written by Yue, Wen-Jun;Day, Craig S.;Martin, Ruben. And the article was included in Journal of the American Chemical Society in 2021.Application of 109-85-3 The following contents are mentioned in the article:

A site-selective defluorinative sp³ C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp³ sites was disclosed. This protocol was distinguished by its mild conditions, wide scope and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Improved Synthesis of 1λ;⁶,2,4,6-Thiatriazine-1,3,5-trione Derivatives – the Sulfonimidamide-featured Triazinones was written by Chen, Yantao;Kollback, Johanna;Aurell, Carl-Johan. And the article was included in ChemistrySelect in 2022.Related Products of 109-85-3 The following contents are mentioned in the article:

N,N’-dicarbamoylation of 4-methylbenzenesulfonimidamide with carbonyldiimidazole, followed by a mono-nucleophilic substitution with amines and subsequential ring closure in one-pot, afforded 1λ6,2,4,6-thiatriazine-1,3,5-trione derivatives I [R = cyclohexyl, Ph, 3-pyridyl, etc.] in up to 83% yields. The protocol also worked well for aliphatic sulfonimidamides, such as Me sulfonimidamide. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Related Products of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem