Category: 109-85-3

Efficient asymmetric biomimetic aldol reaction of glycinates and trifluoromethyl ketones by carbonyl catalysis was written by Cheng, Aolin;Zhang, Liangliang;Zhou, Qinghai;Liu, Tao;Cao, Jing;Zhao, Guoqing;Zhang, Kun;Song, Guanshui;Zhao, Baoguo. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 109-85-3 The following contents are mentioned in the article:

The direct asym. aldol reaction of glycinates represents an intriguing and straightforward strategy to make biol. significant chiral β-hydroxy-α-amino-acid derivatives But it is not easy to realize the transformation due to the disruption of the reactive NH₂ group of glycinates. Inspired by the enzymic aldol reaction of glycine, we successfully developed an asym. aldol reaction of glycinate, NH₂-CH₂ CO-O-tert-Bu, and trifluoromethyl ketones with 0.1-0.0033 mol % of chiral N-Me pyridoxal (I) as the catalyst, producing chiral β-trifluoromethyl-β-hydroxy-α-amino-acid esters 6 in 55-82% yields (for the syn-diastereomers) with up to >20:1 dr and 99% ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymic aldol reaction of glycine. Pyridoxal catalyst I activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Related Products of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photogated photoswitchable [2]rotaxane based on orthogonal photoreactions was written by Yang, Jiang-Xiong;Li, Ze;Gu, Xu-Hai;Zhan, Tian-Guang;Cui, Jiecheng;Zhang, Kang-Da. And the article was included in Tetrahedron in 2021.Application In Synthesis of 2-Methoxyethylamine The following contents are mentioned in the article:

A photoswitchable [2]rotaxane with unique photogated macrocyclic shuttling is constructed by incorporating the photoswitchable azobenzene (AB) and nonphotoactive biphenyl (BP) units into the axle as two terminal recognition sites, bridged by a naphthalene (NAP) unit. The UV (λ = 379 nm)/blue (λ = 440-450 nm) lights triggered Z/E photoisomerization of the AB unit can drive the cyclobis(paraquat-p-phenylene) (CBPQT⁴⁺) macrocycle to shuttle between the two terminal recognition sites. Such macrocyclic translational movement can be photogated by a steric barrier generating from the green-light (λ = 520-525 nm)-triggered cycloaddition reaction between the NAP unit on the thread and a triazolinedione (TAD) additive. Upon standing in dark, the photocycloadduct undergoes disassocn. which restores the phototriggered macrocyclic shuttling ability. The construction of such photogated photoresponsive mol. shuttle can provide new approach to improve the switching controllability of rotaxane, which is beneficial to fabricate rotaxane-based nanosystems and materials with high performance. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application In Synthesis of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros was written by Baumann, Georg;Meckel, Tobias;Boehm, Kevin;Shih, Yung-Hsin;Dickhaut, Mirco;Reichardt, Torben;Pilakowski, Johannes;Pehl, Ulrich;Schmidt, Boris. And the article was included in Journal of Medicinal Chemistry in 2022.HPLC of Formula: 109-85-3 The following contents are mentioned in the article:

NIMA-related kinase 1 (Nek1) has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the DNA-damage response. Despite its involvement in various diseases and its potential as a cancer drug target, no directed medicinal chem. efforts toward inhibitors against this dark kinase are published. Here, we report the structure-guided design of a potent small-mol. Nek1 inhibitor, starting from a scaffold identified by kinase cross-screening anal. Seven lead compounds were identified in silico and evaluated for their inhibitory activity. The top compound, 10f, was further profiled for efficacy, toxicity, and bioavailability in a zebrafish polycystic kidney disease model. Administration of 10f caused the expansion of fluorescence-labeled proximal convoluted tubules, supporting our hypothesis that Nek1-inhibition causes cystic kidneys in zebrafish embryos. Compound 10f displayed insignificant inhibition in 48 of 50 kinases in a selectivity test panel. The findings provide a powerful tool to further elucidate the function and pharmacol. of this neglected kinase. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3HPLC of Formula: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents was written by Wu, Yu;Cheung, Chen-Yi;Zhou, Yang;Wang, Zhen;Tu, Zhengchao;Cook, Gregory M.;Lu, Xiaoyun. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and extensive drug-resistant strains (XDR-TB), there is an urgent need to develop novel drugs for the treatment of tuberculosis. Here, the authors designed and synthesized a series of 5-methylpyrimidopyridone analogs I [R¹ = NHEt, cyclopropylamino, 4-methylpiperidino, etc., R² = (3s,5S,7s)-adamant-1-yl, cyclopentyl, cyclohexyl, R³ = 2-Cl, 4-Cl, H, 2-CN, etc.] as potential antitubercular agents. The most potent compound II exhibited a MIC value of 4μM in vitro against Mycobacterium tuberculosis. The antitubercular activities of the synthesized compounds were impacted by the amantadine and 2-chlorophenyl groups, and were enhanced by the presence of 3-methyl(4-dimethylamino)piperidinylphenyl. Mol. modeling and binding studies suggest that PknB is the potential mol. target of 5-methylpyrimidopyridone compounds This study provides insights for the future development of new antimycobacterial agents with novel mechanisms of action. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies was written by Soares de Melo, Candice;Singh, Vinayak;Myrick, Alissa;Simelane, Sandile B.;Taylor, Dale;Brunschwig, Christel;Lawrence, Nina;Schnappinger, Dirk;Engelhart, Curtis A.;Kumar, Anuradha;Parish, Tanya;Su, Qin;Myers, Timothy G.;Boshoff, Helena I. M.;Barry, Clifton E. III;Sirgel, Frederick A.;van Helden, Paul D.;Buchanan, Kirsteen I.;Bayliss, Tracy;Green, Simon R.;Ray, Peter C.;Wyatt, Paul G.;Basarab, Gregory S.;Eyermann, Charles J.;Chibale, Kelly;Ghorpade, Sandeep R.. And the article was included in Journal of Medicinal Chemistry in 2021.Formula: C3H9NO The following contents are mentioned in the article:

Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biol. triage of these actives using various tool strains of Mtb suggested a novel mechanism of action. The compounds were bactericidal against replicating Mtb and retained potency against clin. isolates of Mtb. Although selected MmpL3 mutant strains of Mtb showed resistance to these compounds, there was no shift in the min. inhibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible resistance mechanism for the compounds but not necessarily as the target. RNA transcriptional profiling and the checkerboard board 2D-MIC assay in the presence of varying concentrations of ferrous salt indicated perturbation of the Fe-homeostasis by the compounds Structure-activity relationship studies identified potent compounds with good physicochem. properties and in vitro microsomal metabolic stability with moderate selectivity over cytotoxicity against mammalian cell lines. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein was written by Hu, Yanmei;Kitamura, Naoya;Musharrafieh, Rami;Wang, Jun. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

The enterovirus genus of the picornavirus family contains many important human pathogens. EV-D68 primarily infects children, and the disease manifestations range from respiratory illnesses to neurol. complications such as acute flaccid myelitis (AFM). EV-A71 is a major pathogen for the hand, foot, and mouth disease (HFMD) in children and can also lead to AFM and death in severe cases. CVB3 infection can cause cardiac arrhythmias, acute heart failure, as well as type 1 diabetes. There is currently no FDA-approved antiviral for any of these enteroviruses. In this study, we report our discovery and development of pyrazolopyridine-containing small mols. such as I with potent and broad-spectrum antiviral activity against multiple strains of EV-D68, EV-A71, and CVB3. Serial viral passage experiments, coupled with reverse genetics and thermal shift binding assays, suggested that these mols. target the viral protein 2C. Overall, the pyrazolopyridine inhibitors represent a promising class of candidates for the urgently needed nonpolio enterovirus antivirals. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Annulation-Triggered Denitrogenative Transformations of 2-(5-Iodo-1,2,3-triazolyl)benzoic Acids was written by Voloshkin, Vladislav A.;Kotovshchikov, Yury N.;Latyshev, Gennadij V.;Lukashev, Nikolay V.;Beletskaya, Irina P.. And the article was included in Journal of Organic Chemistry in 2022.Application of 109-85-3 The following contents are mentioned in the article:

The ability of [1,2,3]triazolobenzoxazinones I (R¹ = H, 7-Br, 9-Me; R² = n-Bu, Ph, cyclohexylmethyl, 3-methylbutyl) to act as a source of “hidden” diazo group was discovered. These diazo precursors can be easily prepared by the intramol. cyclization of 2-(5-iodo-1,2,3-triazolyl)benzoic acids II (R³ = H, 5-Br, 3-Me, etc.). The Cu-catalyzed capture of the hidden diazo group allows for further functionalization through the denitrogenative pathway. The transformations proceed via the formation of either diazoimine or diazoamide intermediates. Novel routes to various anthranilamides R³NHC(O)CH(R²)R⁴ (R³ = 4,5-dimethoxy-2-[(pyrrolidin-1-yl)carbonyl]benzen-1-yl, 2-[(morpholin-4-yl)carbonyl]benzen-1-yl, 4-bromo-2-[(pyrrolidin-1-yl)carbonyl]benzen-1-yl, etc.; R⁴ = pyrrolidin-1-yl, (5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl, morpholin-4-yl, etc.) as well as thiolated benzoxazinones III (R⁵ = 5-methyl-1,3,4-thiadiazol-2-yl, 1,3-benzoxazol-2-yl, 1-methyl-1H-1,2,3,4-tetrazol-5-yl, etc.) were developed using the one-pot cyclization/diazo capture procedure. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A novel N-nitrosation-based ratiometric fluorescent probe for highly selective imaging endogenous nitric oxide in living cells and zebrafish was written by Liu, Peilian;Li, Bowen;Zheng, Jian;Liang, Qiqi;Wu, Cailing;Huang, Liping;Zhang, Peisheng;Jia, Yongmei;Wang, Sheng. And the article was included in Sensors and Actuators, B: Chemical in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

Nitric oxide (NO), a widespread signaling transduction mol. in organism, plays key roles in lots of pathophysiol. processes. Aberrant level of NO is closely related to tumors, cardiovascular and cerebrovascular diseases, neurodegenerative diseases and many other diseases. Therefore, sensing NO in cells and in vivo is of great significance for the study of the chem. biol. of related diseases. Herein, a novel ratiometric fluorescence probe (AC-SA), in which anthracene carboximide used as fluorophore and secondary amines at the 6th position of the fluorophore severed as recognition moiety is rationally designed to detect NO. The AC-SA can capture NO via N-nitrosation reaction to give obvious fluorescence signal change from red to green based on the intramol. charge transfer (ICT) mechanism. The AC-SA features striking ratiometric signal (I525/I625), good sensitivity (4.05 nM), high selectivity for sensing NO over various interferents in physiol. pH. More important, the AC-SA can be applied to image endogenous NO in Raw 264.7 macrophage cells as well as zebrafish in a ratiometric manner. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cobalt(II) complexes supported by iminomethylpyridine derived ligands: Synthesis, characterization and catalytic application towards methyl methacrylate and rac-lactide polymerisations was written by Lee, Jaegyeong;Kim, Kyeonghun;Lee, Hyosun;Nayab, Saira. And the article was included in Polyhedron in 2021.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

A series of cobalt(II) complexes, [L_nCoCl₂] (L_n = L-A – L-F), supported by iminomethylpyridine derivatives were synthesized. The crystal structures of [L-ACoCl₂], [L-DCoCl₂] and [L-ECoCl₂] were identified by X-ray diffraction studies and they showed five-coordinated distorted square pyramidal geometries. All the complexes synthesized were evaluated as potential mediators for the coordination polymerization of Me methacrylate (MMA), in the presence of modified methylaluminoxane (MMAO). The Co(II) complex with the ligand (E)-N’,N’-dimethyl-N³-(pyridin-2-ylmethylene)propane-1,3-diamine displayed the highest catalytic activity (4.48 x 10⁴ g PMMA / mol Co h) for MMA polymerization Regardless of the ligand architecture, syndio-enriched poly(Me methacrylate) (PMMAs) with high mol. weights (11.1 x 10⁵ g/mol) were furnished. Addnl., the in situ generated di-Me Co(II) complexes polymerized racemic-lactide (rac-LA), yielding hetero-enriched polylactide (PLA). Importantly, the stereoselectivities of the Co(II) complexes towards PLA were found to be influenced by the steric and electronic properties of the amine substituents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase was written by Cheuka, Peter Mubanga;Centani, Luyanda;Arendse, Lauren B.;Fienberg, Stephen;Wambua, Lynn;Renga, Shoneeze S.;Dziwornu, Godwin Akpeko;Kumar, Malkeet;Lawrence, Nina;Taylor, Dale;Wittlin, Sergio;Coertzen, Dina;Reader, Janette;van der Watt, Mariette;Birkholtz, Lyn-Marie;Chibale, Kelly. And the article was included in ACS Infectious Diseases in 2021.Recommanded Product: 109-85-3 The following contents are mentioned in the article:

Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogs and demonstrate that these compounds potently inhibit Plasmodium phosphatidylinositol-4-kinase (PI4K) type IIIβ while moderately inhibiting cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) activity in vitro. Using in silico docking, we predict key binding interactions for these analogs within the ATP (ATP)-binding site of PI4K and PKG, paving the way for structure-based optimization of imidazopyridazines targeting both Plasmodium PI4K and PKG. While several derivatives showed low nanomolar antiplasmodium activity (IC₅₀ < 100 nM), some compounds, including piperazine analog I, resulted in strong dual PI4K and PKG inhibition. The compounds also demonstrated transmission-blocking potential, evident from their potent inhibition of early- and late-stage gametocytes. Finally, the current compounds generally showed improved aqueous solubility and reduced hERG (human ether-a-go-go-related gene) channel inhibition. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem