Category: 109-85-3

Ring opening and skeletal reconstruction of 3-vinyl benzofuranone-chromone synthons: catalyst-free access to skeletally-diverse 2-pyridone and optically active imidazoline derivatives was written by Wang, Wei-Na;Liu, Ren-Ming;Zhang, Lei;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 109-85-3 The following contents are mentioned in the article:

Herein the first example of ring opening and skeletal reconstruction of 3-vinyl benzofuranone-chromones as versatile synthons, which could react with ammonia or primary aliphatic amines as binucleophiles, for the eco-friendly and atom-economical synthesis of diverse and functionalized 2-pyridones with potential biol. activity in good to excellent yields (77-93%) was reported. When using optically active 1,2-diphenylethylenediamine as the binucleophile, the in situ generated 2-pyridone intermediates were successfully transformed to novel optically active functionalized imidazoline derivatives with high efficiency (up to 87% yield). In particular, this was the first report on the catalyst-free intramol. cyclization occurring between an amide and a primary aliphatic amine for the construction of imidazoline mols. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photochemical Ring Contraction of 5,5-Dialkylcyclopent-2-enones and in situ Trapping by Primary Amines was written by Jeremias, Noah;Peschel, Martin T.;Jaschke, Constantin;de Vivie-Riedle, Regina;Bach, Thorsten. And the article was included in Journal of Organic Chemistry.Formula: C3H9NO The following contents are mentioned in the article:

If substituted in the 5,5-position, cyclopent-2-enones undergo a smooth photochem. rearrangement to ketenes. A concomitant cyclopropane formation occurs due to a 1,3-shift of the C5 carbon atom from the carbonyl carbon atom (C1) to carbon atom C3. In this study, the cyclopropyl-substituted ketene intermediates were trapped in situ by primary amines providing an efficient entry into 2,2-disubstituted cyclopropaneacetic amides (24 examples, 49-95% yield). A remarkable feature of the reaction is the fact that the photochem. rearrangement can occur from either the first excited singlet (S₁) or the resp. triplet state (T₁). In line with exptl. results (triplet quenching, sensitization), XMS-CASPT2 calculations support the existence of efficient reaction pathways to the intermediate ketene both on the singlet and on the triplet hypersurface. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Distorted zinc coordination polyhedra in bis(1-ethoxy-2-{[(2-methoxyethyl)imino]methyl}propan-1-olato)zinc, a possible CVD precursor for zinc oxide thin films was written by Johnson, Keneshia O.;Brown, Antionette;Farris, Gabriella;Starks, Alexabria;Butcher, Ray J.;Matthews, Jason S.. And the article was included in Acta Crystallographica in 2022.Related Products of 109-85-3 The following contents are mentioned in the article:

A new metal-organic precursor for the chem. vapor deposition of zinc oxide thin films, [Zn(C₉H₁₆NO₃)₂], has been synthesized and characterized by ¹H and ¹³C NMR spectroscopy, single-crystal X-ray diffraction and thermogravimetric anal. The asym. unit of the title compound consists of two mols. (Z′ = 2), with different zinc coordination polyhedra. In one mol., the metal atom is in a distorted trigonal-bipyramidal ZnN₂O₃ environment (τ5 = 0.192) with a long bond to an ether O donor atom [Zn-O = 2.727 (6) Å]. In the other, the Zn atom is in a distorted ZnN₂O₄ octahedral environment with long bonds to the ether O donors of both ligands [Zn-O = 2.514 (4) and 2.661 (4) Å; O-Zn-O = 82.46 (14)°]. The crystal structure features weak C-H····O interactions. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Related Products of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis and anti-TNBC activity of Azeliragon triazole analogues was written by Xie, Jizhao;Xu, Huanji;Wu, Xinduo;Xie, Yunfeng;Lu, Xiuhong;Wang, Lisheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

Triple-neg. breast cancer (TNBC) is the most aggressive subtype of breast cancer. Many studies have shown a significant increase in the marker signal of the receptor for advanced glycation end-products (RAGE) with the malignant progression of tumor growth, metastasis and recurrence of breast cancer, including TNBC of primary tumors and lymph node metastases. Azeliragon is a RAGE inhibitor and it has been shown to actively inhibit the TNBC cell line, SUM149 (IC₅₀ = 5.292 ± 0.310 μM). In order to develop a new anti-TNBC agent, we designed, synthesized and screened 26 Azeliragon triazole analogs to determine their anti-TNBC activities in vitro. The most active compound was KC-10 (3-(4-(5-butyl-1-(4′-chloro-[1,1′-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)phenoxy)-N, N-diethylpropan-1-amine) with an IC₅₀ value of 0.220 ± 0.034 μM. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Proton-Mediated Practical Synthesis of McGeachin-Type Bisaminals was written by Chen, Yang;Wang, Tingting;Du, Hongguang;Xu, Jiaxi;Yang, Zhanhui. And the article was included in Synthesis in 2021.Reference of 109-85-3 The following contents are mentioned in the article:

A proton-mediated practical synthesis of McGeachin-type bisaminals I (R = R¹ = H, Br, OMe; R² = t-Bu, prop-2-en-1-yl, cyclohexyl, naphthalen-1-yl, furan-2-ylmethyl, etc.) from 2-(alkylamino)arenecarbaldehydes 2-(NHCH₃)-5-RC₆H₃CHO and primary amines R²NH₂ is achieved, with trifluoroacetic acid as the proton donor. The use of a proton, a smallest electrophilic activator, allows previously inviable ortho-substituted anilines and linear and branched aliphatic amines R²NH₂ to be viable substrates for McGeachin bisaminal synthesis I. Overcoming the steric and electronic limitations provides a practical synthetic method. The applications in product derivation and pharmaceutical mol. modification are also demonstrated. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium was written by Zhang, Yan;Lin, Zhipeng;Ackermann, Lutz. And the article was included in Chemistry – A European Journal in 2021.Application of 109-85-3 The following contents are mentioned in the article:

The construction of C-N bonds by free radical reactions represents a powerful synthetic approach for direct C-H amidations of arenes or heteroarenes. Developing efficient and more environmentally friendly synthetic methods for C-H amidation reactions remains highly desirable. Herein, metal-free electrochem. oxidative dehydrogenative C-H amidations of heteroarenes with N-alkylsulfonamides have been accomplished. The catalyst- and chem.-oxidant-free C-H amidation features an ample scope and employs electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp²)-H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells was written by Song, Peilu;Zhao, Fan;Li, Dahong;Qu, Jiqiang;Yao, Miao;Su, Yuan;Wang, Hanxun;Zhou, Miaomiao;Wang, Yujie;Gao, Yinli;Li, Feng;Zhao, Dongmei;Zhang, Fengjiao;Rao, Yu;Xia, Mingyu;Li, Haitao;Wang, Jian;Cheng, Maosheng. And the article was included in Acta Pharmaceutica Sinica B in 2022.Product Details of 109-85-3 The following contents are mentioned in the article:

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallog. and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity towards group II PAKs. Among these inhibitors, compound 55 exhibited excellent inhibitory activity and kinase selectivity, displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16. Compound 55 exhibited potent in vivo antitumor metastatic efficacy, with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models, resp. Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition (EMT). This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, Neurotropic Activity, and Molecular Docking of New Condensed Thieno[2,3-b]pyridine Derivatives was written by Dabaeva, V. V.;Baghdasaryan, M. R.;Paronikyan, R. G.;Nazaryan, I. M.;Hakobyan, H. G.;Hunanyan, L. S.;Paronikyan, E. G.;Dashyan, Sh. Sh.. And the article was included in Russian Journal of Bioorganic Chemistry in 2022.Application In Synthesis of 2-Methoxyethylamine The following contents are mentioned in the article:

Methods for the preparation of new condensed derivatives of pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were developed. Substitution reactions in the 3rd and 4th positions of 7,8-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one were conducted. The neurotropic activity of 12 obtained compounds was studied in vivo in rats and mice. Eight compounds were found to have an anticonvulsant effect of antagonism with corazole. Four selected compounds had anxiolytic and behavior activating effects. Mol. docking of the synthesized compounds was performed to predict their interaction with the GABAA receptor. Five compounds were identified, the complexation of which with the GABAA receptor occurs in two places: the benzamidine site of subsite 1 and subsite 3 of the ECD interface, which indicates the inhibitory effect of the compounds on the target. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application In Synthesis of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter was written by Diaz, Jose Luis;Cuevas, Felix;Pazos, Gonzalo;Alvarez-Bercedo, Paula;Oliva, Ana I.;Sarmentero, M. Angeles;Font, Daniel;Jimenez-Aquino, Agustin;Moron, Maria;Port, Adriana;Pascual, Rosalia;Dordal, Albert;Portillo-Salido, Enrique;Reinoso, Raquel F.;Vela, Jose Miguel;Almansa, Carmen. And the article was included in Journal of Medicinal Chemistry in 2021.Application of 109-85-3 The following contents are mentioned in the article:

The synthesis and pharmacol. activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the positions amenable for substitution on a nonaminoacidic Ca_vα2δ-1 scaffold allowed the identification of favorable positions for the attachment of NET pharmacophores. Among the patterns explored, attachment of the 2-ethylamino-9-methyl-6-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one framework to the meta-position of the Ph ring of the 3-methylamino-1-phenylpropoxy and 3-methylamino-1-thienylpropoxy moieties provided dual compounds with excellent NET functionality. Alternative bicyclic frameworks were also explored, and some lead mols. were identified, which showed a balanced dual profile and exhibited good ADMET properties. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists was written by Mahindra, Amit;Jenkins, Laura;Marsango, Sara;Huggett, Mark;Huggett, Margaret;Robinson, Lindsay;Gillespie, Jonathan;Rajamanickam, Muralikrishnan;Morrison, Angus;McElroy, Stuart;Tikhonova, Irina G.;Milligan, Graeme;Jamieson, Andrew G.. And the article was included in Journal of Medicinal Chemistry in 2022.Electric Literature of C3H9NO The following contents are mentioned in the article:

G-protein-coupled receptor 84 (GPR84) is a proinflammatory orphan G-protein-coupled receptor implicated in several inflammatory and fibrotic diseases. Several agonist and antagonist ligands have been developed that target GPR84; however, a noncompetitive receptor blocker that was progressed to phase II clin. trials failed to demonstrate efficacy. New high-quality antagonists are required to investigate the pathophysiol. role of GPR84 and to validate GPR84 as a therapeutic target. Here, authors describe an extensive structure-activity relationship (SAR) of antagonist compound I and also present in silico docking with supporting mutagenesis studies that reveals a potential binding pose for this type of orthosteric antagonist. Lead compound II is a potent GPR84 antagonist with a favorable pharmacokinetic (PK) profile suitable for further drug development. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Electric Literature of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem