Application of 106877-20-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106877-20-7, name is 3-Methoxy-4-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows.
step 3-; A 100 mL round bottom flask fitted with a stir bar and septum was charged with 84a (3.01) g and maintained nitrogen atmosphere. To the flask was added anhydrous dioxane (25 mL) and HOAc (7.5 mL). The solution was stirred rapidly in an ice bath and a solution of bromine and dioxane (20 mL, 0.135 g Br2/mL) was added dropwise over 30 min using a syringe pump. A beige precipitate formed and the mixture thickened. The ice bath was removed and the reaction mixture stirred at RT for 1 h. The reaction mixture was poured into a mixture of 1.0 M NaOH (150 mL) and 2.0 M Na2CO3 (150 mL) and extracted with DCM (3¡Á100 mL). The combined extracts were washed sequentially with 0.5 M Na2CO3 (150 mL) and brine (150 mL), dried (Na2SO4), filtered and concentrated in vacuo. The resulting pale yellow liquid slowly solidified and darkened to afford 84b (4.10 g) black crystalline solid.
The chemical industry reduces the impact on the environment during synthesis 3-Methoxy-4-(trifluoromethyl)aniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; de Vicente Fidalgo, Javier; Li, Jim; Schoenfeld, Ryan Craig; Talamas, Francisco Xavier; Taygerly, Joshua Paul Gergely; US2010/311760; (2010); A1;,
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