Category: 10541-78-3

Katayama, Shintaro; Nishino, Hiroshi published the artcile< Manganese(III)-Based Oxidative Cyclization of N -Aryl-2-oxocycloalkane-1-carboxamides: Synthesis of Spiroindolinones>, Application In Synthesis of 10541-78-3, the main research area is aryl oxocycloalkane carboxamide oxidative cyclization; spiro cycloalkane indoline dione preparation.

The Mn(III)-based oxidative cyclization of twenty-five N-aryl-2-oxocycloalkane-1-carboxamides was investigated. The reactions progressed efficiently to give the desired spiro[cycloalkane-1,3′-indoline]-2,2′-diones in high to quant. yields. The easy conversion of the carbonyl functional group of one of the indoline products, 1′-methylspiro[cyclohexane-1,3′-indoline]-2,2′-dione, was also demonstrated.

Synthesis published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phan Thi Thanh, Nga; Dang Thi Thu, Huong; Tone, Masaya; Inoue, Hayato; Iwasa, Seiji published the artcile< Synthesis of Oxindole Derivatives via Intramolecular C-H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst>, Electric Literature of 10541-78-3, the main research area is oxindole preparation regioselective; diazoacetamide preparation insertion reaction ruthenium catalyst.

This work presented the efficient intramol. aromatic C-H insertion of diazoacetamide. The diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramol. C-H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min-1 (TOF).

Tetrahedron published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (diazo). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Electric Literature of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bonnefoy, Clemence; Chefdeville, Emmanuel; Tourvieille, Christian; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic; Toulgoat, Fabien; Billard, Thierry published the artcile< Study of Carbamoyl Fluoride: Synthesis, Properties and Applications>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is carbamoyl fluoride preparation stability; amine fluorocarbonylation dinitrotrifluoromethoxybenzene; radiolabeled carbamoyl fluoride preparation; carbamoyl fluorides; dinitrotrifluoromethoxybenzene; fluorine; radiochemistry; trifluoromethoxide.

In this study, the little-explored carbamoyl fluorides have been studied in order to bring relevant information for their application to the community of chemists. A new easy, safe, inexpensive, and metal-free synthesis method is also described. Finally, a potential use in radiochem. through a 18F/19F isotopic exchange is demonstrated.

Chemistry – A European Journal published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 10541-78-3, name is 2-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10541-78-3, Formula: C8H11NO

Phosgene (5 mL, 20% in toluene) was added to a stirred suspension of 6′-hydroxy-4,4-dimethyl-4,5-dihydro-3/-/-[1,3′]bipyridinyl-2,6-dione (0.47 g, 2.00 mmol) and triethylamine(0.29 mL, 2.00 mmol) in dichloromethane (10 mL). After stirring for 0.75 h at room tempera- ture, the solvent and excess phosgene were evaporated under reduced pressure, yielding awhite solid. The residue was dissolved in dichloromethane (10 mL) followed by the additionof 1,4-diazabicyclo[2.2.2]octane (224 mg, 2.00 mmol) and 2-methoxy-/V-methylaniline (0.27g, 2.00 mmol) and stirring was continued for 0.75 hours at room temperature. The solutionwas extracted with water and evaporated in vacuo. The residue was purified by flash columnchromatography (SiO2, gradient of 0-15% ethyl acetate in dichloromethane), yielding the titlecompound (260 mg, 33% yield) as a white solid.1H NMR (300 MHz, CDC13): 8 = 1.19 (s, 6H), 2.66 (s, 4H), 3.29 + 3.40 (2 x s, 3H), 3.86 (s,3H), 6.94 (m, 2H), 7.04-7.54 (m, 4H), 8.03 + 8.12 (d + s, 1H); HPLC-MS (Method A): m/z =398 (M+H)+; Rt = 3.62 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVO NORDISK A/S; WO2004/111031; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 10541-78-3, name is 2-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10541-78-3, HPLC of Formula: C8H11NO

To a stirring dichloromethane (40 mL) solution containing 5-bromo-4- chloro-2-hydroxybenzoic acid (2.0 g, 8.0 mmol), were added triethylamine (2.2 mL, 16.0 mmol), HATU (4.5 g, 12 mmol) and 2-methoxyl-N-methylaniline (1.19 g, 8.7 mmol). The mixture was stirred at rt for 16 hrs and water was added. The organic layer was separated, washed with NaHCO3, dried over Na2SO4, filtered and concentrated. The residue was purified via silica gel flash column chromatography eluting with 20% ethyl acetate in hexane to afford 5-bromo-4-chloro-2-hydroxy-N-(2- methoxy-phenyl)-N-methyl-benzamide (300 mg). MS [M+H]+: 371.9; tR = 2.60 min (method 1)Alternatively, a mixture of 5-bromo-4-chloro-2-hydroxybenzoic acid (5 g, 19.9 mmol), 2-methoxy-N-methyaniline (3.13g, 22.9 mmol) and P2O5 (5.36g, 37. 8 mmol) in anhydrous xylene was heated at 60 0C for 2 hrs and then refluxed for 17 hrs. The mixture was concentrated and purified via silica gel flash column chromatography eluted with ethyl acetate in hexane (20%) to give 5-bromo-4-chloro-2-hydroxy-N-(2- methoxy-phenyl)-N-methyl-benzamide (3.3 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2008/124610; (2008); A1;,
Ether – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10541-78-3, name is 2-Methoxy-N-methylaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11NO

General procedure: A mixture of secondary amine 1 (200 mg, 1 equiv), polyformaldehyde 2 (1.5 equiv) and the activated alkene 3 (1.1 equiv) was dissolved in acetonitrile (2 mL). The solution was stirred at room temperature for 3 days until the starting secondary amine 1 was no longer detected by TLC (revealed with an ethanolic solution of vanillin-sulfuric acid or iodine). After the excess of solvent was removed under reduced pressure, the oily material obtained was purified by column chromatography on silica gel (70-230 mesh), using CHCl3:MeOH mixtures of (30:1, 20:1 or 15:1) as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Abonia, Rodrigo; Castillo, Juan C.; Garay, Alexander; Insuasty, Braulio; Quiroga, Jairo; Nogueras, Manuel; Cobo, Justo; D’Vries, Richard; Tetrahedron Letters; vol. 58; 15; (2017); p. 1490 – 1494;,
Ether – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10541-78-3, name is 2-Methoxy-N-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Methoxy-N-methylaniline

(a) 5-Methoxy-4-methyl-2H-benzo[e][1 ,2,4]thiadiazin-3(4H)-one 1 ,1 -dioxide (2913) To a vigorously stirred solution of chlorosulfonyl isocyanate (1 .52 mL) in 1 -nitropropane (20 mL) at -40 C, under nitrogen, was slowly added over 10 min a solution of 2-methoxy-N- methylaniline (2.0 g) in 1 -nitropropane (10 mL). The mixture was then allowed to warm to RT and stirred for 60 min. Anhydrous aluminum chloride (2.53 g) was added and the mixture was then allowed to stir at 120 C for 2 h. The hot solution was poured onto ice (~40 g) and, after stirring and complete melting of ice, the resulting precipitate was collected by filtration and rinsed with water (5 mL). The insoluble crude material was suspended in an aqueous solution of NaHC03 (1 .5 g/30 mL) and heated until most of the precipitate was dissolved. The suspension was filtered, and the filtrate was adjusted to pH ~1 with 6 N HCI. The resulting solid was collected by filtration, rinsed with water, and dried to give the titled compound (0.79 g) as a yellowish solid. LCMS m/z 242.9 (M+H); 1H NMR (400 MHz, DMSO-c/e) delta ppm 3.40 (s, 3H), 3.92 (s, 3H), 7.38-7.50 (m, 3H).

The synthetic route of 10541-78-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 10541-78-3, The chemical industry reduces the impact on the environment during synthesis 10541-78-3, name is 2-Methoxy-N-methylaniline, I believe this compound will play a more active role in future production and life.

EXAMPLE 3 STR52 (Process (a)) 5.69 g (0.02 mol) of 2-chlorosulphonylaminocarbonyl-4-ethyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one are introduced into 150 ml of methylene chloride, and a solution of 2.74 g (0.02 mol) of 2-methoxy-N-methylaniline and 2.02 g (0.02 mol) of triethylamine in 20 ml of methylene chloride is added to this mixture at 20 C. The reaction mixture is stirred for 60 minutes at 20 C. It is then washed three times using 150 ml of water in each case, dried using sodium sulphate and filtered. The filtrate is concentrated under a water pump vacuum and the residue is recrystallized from isopropanol. 3.2 g (40% of theory) of 2-(2-methoxy-N-methyl-phenylamino)-sulphonylaminocarbonyl-4-ethyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one of melting point 134 C. are obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US5654438; (1997); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10541-78-3, name is 2-Methoxy-N-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Methoxy-N-methylaniline

EXAMPLE VI Preparation of N’-(4-Ethoxycarbonylphenyl)-N-(2-methoxyphenyl)-N-methylformamidine A mixture of ethyl N-(4-ethoxycarbonylphenyl)formimidate (Example Ia) (4.9 g, 0.022 mol) and 2-methoxy-N-methylaniline (3.2 g, 0.022 mol) were heated at 180 until 1.3 ml of ethanol had been collected by distillation. The resulting yellow oil was flash distilled to yield the desired product, bp~200 C. (0.05 mm).

The synthetic route of 10541-78-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Givaudan Corporation; US4021471; (1977); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10541-78-3, name is 2-Methoxy-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Methoxy-N-methylaniline

General procedure: The N-methyl aniline intermediates were prepared according to the method in the literature. To a solution of sodium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate (2) (130 mg, 0.5 mmol) in water (15 mL), N-methyl aniline intermediate (0.55 mmol) was added. The reaction mixture was stirred at room temperature for 3 to 20 h (TLC monitoring). For the preparation of compounds 3, the solvent was removed in vacuum, and the residue was purified by column chromatography to give the target products. For the preparation of compounds 4, the precipitate produced was filtered, and the residue was crystallized from EtOH to give compounds 4 as red solids.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10541-78-3.

Reference:
Article; Yang, Honghao; An, Baijiao; Li, Xingshu; Zeng, Wei; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3057 – 3063;,
Ether – Wikipedia,
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