Category: 10541-78-3

Sun, Wei; Raimbach, William A. T.; Elliott, Luke D.; Booker-Milburn, Kevin I.; Harrowven, David C. published the artcile< New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis>, Product Details of C8H11NO, the main research area is aryl amino cycloalkenone iodine catalyst oxidative photocyclization; tetrahydro cycloalkaindolone preparation; arylamino alkenone iodine catalyst oxidative photocyclization; indolyl alkenone preparation.

An oxidative photocyclization of N-arylenaminones to indoles was described, that mirrored the Fischer indole synthesis but used anilines in place of arylhydrazines. Its value was exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Katayama, Shin-taro; Nishino, Hiroshi published the artcile< Facile synthesis of spiro[cyclohexane-1,3'-indoline]-2,2'-diones>, Computed Properties of 10541-78-3, the main research area is phenyl methyl oxocyclohexane carboxamide preparation one pot oxidative heterocyclization; methylspiro oxocyclohexane indolinone preparation.

Spiro[cyclohexane-1,3′-indoline]-2,2′-diones were easily prepared in good to high yields by the oxidation of N-aryl-N-methyl-2-oxocyclohexane-1-carboxamides in one-pot with a short reaction time. The spiroindolinediones could be important for the total synthesis of natural products.

Heterocyclic Communications published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Computed Properties of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Yuwei; Niu, Linbin; Liang, Xing-An; Wang, Shengchun; Wang, Pengjie; Lei, Aiwen published the artcile< Electrooxidation-Induced C(sp3)-H/C(sp2)-H Radical-Radical Cross-Coupling between Xanthenes and Electron-Rich Arenes>, Safety of 2-Methoxy-N-methylaniline, the main research area is xanthene aryl preparation; arene electrooxidation radical cross coupling xanthene.

Herein, an electrooxidation-induced alkylation of electron-rich arenes, such as anilines, imidazo[1,2-a]pyridines, etc., with xanthenes with H2 evolution under exogenous oxidant-free conditions, avoiding the utilization of metal catalysts, is reported. This protocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds This electro-oxidative C(sp3)-H arylation represents an important expansion for the classic arenes alkylation, thereby proving that an attractive strategy for the developments of radical cross-coupling chem. was anticipated.

Chinese Journal of Chemistry published new progress about Alkylation. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Safety of 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yan; Bian, Yuemin; Wang, Jian-Wei; Gong, Ting-Ting; Ying, You-Min; Ma, Lie-Feng; Shan, Wei-Guang; Xie, Xiang-Qun; Zhan, Zha-Jun published the artcile< Effects of α-Mangostin Derivatives on the Alzheimer's Disease Model of Rats and Their Mechanism: A Combination of Experimental Study and Computational Systems Pharmacology Analysis>, Application of C8H11NO, the main research area is mangostin derivative preparation Alzheimer’s neuroprotectant memory learning cognition.

α-Mangostin (α-M) is a natural xanthone from the pericarp of fruit Garcinia mangostana and possesses versatile biol. activities. α-M has a therapeutic potential to treat Alzheimer’s disease (AD) because of its anti-inflammatory, antioxidative, and neuroprotective activities. However, the use of α-M for AD treatment is limited due to its cytotoxic activities and relatively low potency. Modifications of its chem. structure were needed to reduce its cytotoxicity and improve its therapeutic potential against AD. For this purpose, 16 α-M carbamate derivatives were synthesized. An animal model of AD was established, and the effects of AMG-1 on the spatial learning ability and memory ability were evaluated using behavioral tests. The effect on neuropathol. was tested by histopathol. evaluation, Nissl staining, and silver staining. Computational systems pharmacol. anal. using the chemogenomics knowledgebase was applied for network studies. Compound-target, target-pathway, and target-disease networks were constructed, integrating both in silico anal. and reported exptl. data. The results show that AMG-1 can demonstrate its therapeutic effects in a one-mol., multiple-targets manner to remarkably ameliorate neurol. changes and reverse behavioral deficits in AD model rats. The improved cognitive function and alleviated neuronal injury can be observed The ability of AMG-1 to scavenge β-amyloid in the hippocampus was validated in AD model rats.

ACS Omega published new progress about Alzheimer disease. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Kangkang; Li, Jin-Feng; Yin, Bing; Zeng, Fanlong published the artcile< Investigation of NNN Pincer Ruthenium(II) Complexes with a Pendant Hydroxyl Group for N-Monomethylation of amines and Nitroarenes by Methanol>, Application In Synthesis of 10541-78-3, the main research area is hydroxy trinitrogen NNN pincer ruthenium preparation crystal mol structure; monomethylation amine nitroarene methanol hydroxy trinitrogen pincer ruthenium catalyzed.

A family of air- and moisture-stable NNN pincer ruthenium(II) complexes with a pendant OH were developed, which exhibit unprecedented high reactivity and selectivity in N-monomethylation of amines and nitroarenes using methanol. The study reveals adopting the combination of 1H-pyrazole-1-yl and 3,5-dimethyl-4-hydroxyethyl-1H-pyrazol-1-yl as the two assistant arms of the pyridyl-backbone is a suitable choice. The mechanism study discloses that, during the catalytic cycle, dehydrogenation of methanol to form formaldehyde is a fast and reversible step.

ChemCatChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan published the artcile< Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines>, Application In Synthesis of 10541-78-3, the main research area is trifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination.

Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines.

Nature Communications published new progress about Amination, regioselective. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Shuang; Hong, Xi; Cui, He-Zhen; Zhou, Quan; Lin, Yue-Jian; Hou, Xiu-Feng published the artcile< N-Methylation of ortho-substituted aromatic amines with methanol catalyzed by 2-arylbenzo[d]oxazole NHC-Ir(III) complexes>, Related Products of 10541-78-3, the main research area is arylamine methanol arylbenzoxazole iridium complex catalyst methylation green chem; methyl arylamine preparation.

Seven new chelated cyclometalated Ir complexes of ABON,P, ABON,O and ABON,C(carbene) based on a rigid and tunable 2-arylbenzo[d]oxazole backbone were prepared for the N-methylation of amines. Among these three coordinated modes, ABON,C(carbene)-chelated iridium-based catalysts exhibited good performance in the monomethylation of aromatic amines with methanol (MeOH) as the green methylation reagent. The steric-modified synthesis of ABON,C(carbene) complexes was described. The most active ABON,C(carbene) complex with marginal steric hindrance as a catalyst was obtained from the benzoxazole ring without a substituent and Me group of the benzimidazole ring on the N-heterocyclic carbene (NHC) ligand. A variety of amines including para- and meta-substituted aromatic amines, as well as heterocyclic amines, were formulated as suitable substrates. Importantly, this catalyst considerably promoted the yield of the N-methylation of ortho-substituted aromatic amines. Controlled kinetic experiments and deuterium-labeling reactions of these ortho-substituted amines were conducted under optimized conditions. On the basis of the exptl. results, a plausible mechanism was proposed.

Dalton Transactions published new progress about Benzoxazoles Role: CAT (Catalyst Use), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Related Products of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan published the artcile< Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines>, Application In Synthesis of 10541-78-3, the main research area is trifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination.

Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines.

Nature Communications published new progress about Amination, regioselective. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Shuang; Hong, Xi; Cui, He-Zhen; Zhou, Quan; Lin, Yue-Jian; Hou, Xiu-Feng published the artcile< N-Methylation of ortho-substituted aromatic amines with methanol catalyzed by 2-arylbenzo[d]oxazole NHC-Ir(III) complexes>, Related Products of 10541-78-3, the main research area is arylamine methanol arylbenzoxazole iridium complex catalyst methylation green chem; methyl arylamine preparation.

Seven new chelated cyclometalated Ir complexes of ABON,P, ABON,O and ABON,C(carbene) based on a rigid and tunable 2-arylbenzo[d]oxazole backbone were prepared for the N-methylation of amines. Among these three coordinated modes, ABON,C(carbene)-chelated iridium-based catalysts exhibited good performance in the monomethylation of aromatic amines with methanol (MeOH) as the green methylation reagent. The steric-modified synthesis of ABON,C(carbene) complexes was described. The most active ABON,C(carbene) complex with marginal steric hindrance as a catalyst was obtained from the benzoxazole ring without a substituent and Me group of the benzimidazole ring on the N-heterocyclic carbene (NHC) ligand. A variety of amines including para- and meta-substituted aromatic amines, as well as heterocyclic amines, were formulated as suitable substrates. Importantly, this catalyst considerably promoted the yield of the N-methylation of ortho-substituted aromatic amines. Controlled kinetic experiments and deuterium-labeling reactions of these ortho-substituted amines were conducted under optimized conditions. On the basis of the exptl. results, a plausible mechanism was proposed.

Dalton Transactions published new progress about Benzoxazoles Role: CAT (Catalyst Use), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Related Products of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dobah, Farhaan; Mazodze, C. Munashe; Petersen, Wade F. published the artcile< Cross-Dehydrogenative Cyclization-Dimerization Cascade Sequence for the Synthesis of Symmetrical 3,3'-Bisoxindoles>, Category: ethers-buliding-blocks, the main research area is bisoxindole preparation; oxoalkyl anilide preparation manganese tandem oxidative radical cyclization dimerization.

The synthesis of sym. 3,3′-bisoxindoles from simple acyclic β-oxoanilides were reported. The described method forged three new C-C bonds in a single step via a sequential Mn(OAc)3·2H2O mediated oxidative radical cyclization-fragmentation-dimerization process. The scope of this reaction was demonstrated in the preparation of a variety of 3,3′-bisoxindoles, as well as its application toward the formal synthesis of the Calycanthaceae alkaloid, (±)-folicanthine.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem