Category: 105-13-5

Efficient Synthesis of Imines by Oxidative Coupling Catalyzed by Ce-Mn Oxide Microspheres was written by Chutimasakul, Threeraphat;Tirdtrakool, Warinda;Na Nakhonpanom, Pakamon;Kreethatorn, Hemmarat;Jaruwatee, Pattamaporn;Bunchuay, Thanthapatra;Tantirungrotechai, Jonggol. And the article was included in ChemistrySelect in 2022.Safety of (4-Methoxyphenyl)methanol This article mentions the following:

Oxidative self-coupling of amines and cross-coupling with alcs. are important reactions for the synthesis of imines; however, catalytic systems for these reactions usually require expensive oxidant, complicated catalyst preparation, complex reaction set-up, and/or additives such as bases or cocatalysts. Here, authors report that amorphous cerium-manganese (Ce-Mn) oxides with hierarchical microsphere structure prepared by a facile method could exhibit excellent catalytic performance for the synthesis of various imines using air as the green oxidant under mild conditions. The Ce-Mn oxide heterogeneous catalysts could also be easily recovered and efficiently recycled without significant loss of activities. The excellent activities and the reusability of the Ce-Mn oxide microspheres offer potential advances in the synthesis of imine. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Safety of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bioinspired o-Naphthoquinone-Catalyzed Aerobic Oxidation of Alcohols to Aldehydes and Ketones was written by Baek, Jisun;Si, Tengda;Kim, Hun Young;Oh, Kyungsoo. And the article was included in Organic Letters in 2022.HPLC of Formula: 105-13-5 This article mentions the following:

A biomimetic alc. dehydrogenase (ADH)-like oxidation protocol was developed using an ortho-naphthoquinone (4-(4-fluorophenyl)-1,2-dihydronaphthalene-1,2-dione) catalyst in the presence of a catalytic amount of base. The developed organocatalytic aerobic oxidation of alcs., e.g., 4-chlorobenzyl alc. protocol proceeds through the intramol. 1,5-hydrogen atom transfer of naphthalene alkoxide intermediates, a mechanistically distinctive feature from the previous alc. dehydrogenase mimics that require metals in the active form of catalysts. The ADH-like aerobic oxidation protocol should provide green alternatives to the existing stoichiometric and metal-catalyzed alc. oxidation reactions. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5HPLC of Formula: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cascade upgrading of bio-based 4閳?methoxypropiophenone to anethole enabled by hot-compressed alcohol over a Hf-phytic acid coordination catalyst was written by Tan, Jinyu;Wu, Hongguo;Huang, Jinshu;Jian, Yumei;Zhang, Li-Long;Zhang, Heng;Li, Hu;Yang, Song. And the article was included in Journal of Supercritical Fluids in 2022.Synthetic Route of C8H10O2 This article mentions the following:

Hot compressed solvents (alc., water) have been widely used in the production of value-added chems. from biomass due to their sufficiently low viscosity, high diffusivity, and environmentally-benign features. Anethole (AN) is a unique kind of natural aromatic compound, while its green synthesis method still requires to be explored. Herein, a novel porous acid-base bifunctional phytic acid (PA)-hafnium (Hf)(1:2.5) catalyst was prepared by a simple assembly of PA with Hf under a one-pot hydrothermal method (120 鎺矯, 24 h). The PA-Hf(1: 2.5) possessed outstanding catalytic activity for the synthesis of AN from 4閳?methoxypropiophenone (4-MOPP) at 220 鎺矯 and 15 bar in 2-pentanol (4-MOPP conversion: 99.8%, AN yield: 98.8%), which can be ascribed to its moderate surface area (95.3 m²/g), pore volume (0.18 cm³/g), mesopores (4.0 nm), and acid-base couple sites (d.: 3.6 vs 1.7 mmol/g). 2-Pentanol was determined to serve as the superior hydrogen donor and solvent for the overall conversion process, which can remarkably hinder side reactions in this hot-compressed medium. Moreover, the cooperative interaction of Lewis acid-base couple sites (Hf₄⁺-O₂^–) and Bronsted acidic species (-OH) of PA-Hf(1:2.5) led to its excellent catalytic performance. PA-Hf(1:2.5) was highly reusable with constant activity after five reaction cycles. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Synthetic Route of C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Synthetic Route of C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Regioselective Iodoformylation of Terminal Alkynes to Access Versatile Electrophiles (E)-灏?Iodo-浼?灏?Unsaturated Aldehydes was written by Lu, Dong;Yang, Xiaogang;Guan, Wenjian;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Organic Letters in 2022.Application In Synthesis of (4-Methoxyphenyl)methanol This article mentions the following:

The authors describe a method for synthesizing (E)-灏?iodo-浼?灏?unsaturated aldehydes via the iodoformylation of terminal alkynes with TMSCF₃ and NaI. This synthetic method uses inexpensive and easy-to-handle chem. feedstocks and employs a com. available CuI catalyst. It can transform a broad range of terminal alkynes into bis-electrophile (E)-灏?iodo-浼?灏?unsaturated aldehydes with excellent chemoselectivity, regioselectivity, and stereoselectivity. Moreover, it was demonstrated that this protocol has abundant organic reactivity. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Application In Synthesis of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total Synthesis and Cytotoxic Activity of 7-O-Methylnigrosporolide and Pestalotioprolide D was written by Thiraporn, Aticha;Iawsipo, Panata;Tadpetch, Kwanruthai. And the article was included in Synlett in 2022.Recommanded Product: 105-13-5 This article mentions the following:

A convergent total synthesis of 7- O-methylnigrosporolide and pestalotioprolide D has been accomplished in 17 linear steps and overall yields of 1.7% and 2.6%, resp., starting from ( S)-propylene oxide and ( S)-benzyl glycidyl ether. Our synthesis exploited an acetylide addition and a Shiina macrolactonization to assemble the macrocycle, a Lindlar reduction, and Wittig and Still-Gennari olefinations to construct the three alkene groups, as well as a Jacobsen hydrolytic kinetic resolution to install the stereogenic center. The selection of the silyl protecting group of the C-4 alc. was crucial for the final deprotection step. Our synthesis also led to a hypothesis that pestalotioprolide D might be an artifact of 7- O-methylnigrosporolide. The cytotoxic activities of the two synthetic compounds against six human cancer cell lines were evaluated. Synthetic pestalotioprolide D showed more potent cytotoxic activity than 7-O-methylnigrosporolide against all the cancer cell lines tested, and the SiHa cervical cancer cell line was the most sensitive to both synthetic compounds In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Green, versatile, and scale-up synthesis of amides by aerobic oxidative amination over Ag₂O/P-C₃N₄ photocatalyst was written by Deng, Lanqing;Chen, Lang;Zhu, Liangdi;Li, Yang;Ou-Yang, Jie;Wu, Shaofeng;Chen, Peng;Shen, Sheng;Guo, Junkang;Zhou, Yongbo;Au, Chak-Tong;Yin, Shuang-Feng. And the article was included in Chemical Engineering Science in 2022.Quality Control of (4-Methoxyphenyl)methanol This article mentions the following:

Being extensively applied in various fields of chem. and chem. industry, the development of a green and versatile method for the synthesis of amides is in line with the demand of sustainable chem. Herein, a direct, highly selective, and scale-up (5-20 mmol) method for photocatalytic synthesis of amides through aerobic oxidative amination of alcs. with amines was developed under visible light, room temperature, using air as the oxidant. Benefiting from the adsorption of sodium hemiaminal on catalyst lengthens the C-H bond (1.148 鑴?, this novel process is feasible for a broad range of functionlized amides (69 examples), especially those for drug manufacture (e.g., moclobemide and pipobroman). Imines was almost prevented with excellent amide selectivity up to 99% could be ascribed to the low energy barrier for hemiaminal dehydrogenation while that for dehydration is high (2.13 eV). This green and efficient protocol represents an ideal alternative to the currently known methods. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Quality Control of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles was written by Sun, Kangkang;Shan, Hongbin;Neumann, Helfried;Lu, Guo-Ping;Beller, Matthias. And the article was included in Nature Communications in 2022.Reference of 105-13-5 This article mentions the following:

Zeolitic imidazolate frameworks derived Fe₁-N-C catalysts with isolated single iron atoms were synthesized and applied for selective ammoxidation reactions. For the preparation of the different Fe-based materials, benzylamine as an additive proved to be essential to tune the morphol. and size of ZIFs resulting in uniform and smaller particles, which allowed stable atomically dispersed Fe-N₄ active sites. The optimal catalyst Fe₁-N-C achieved an efficient synthesis of various aryl, heterocyclic, allylic, and aliphatic nitriles from alcs. in water under very mild conditions. With its chemoselectivity, recyclability, high efficiency under mild conditions this new system complemented the toolbox of catalysts for nitrile synthesis, which were important intermediates with many applications in life sciences and industry. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Reference of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Reference of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Site-Selective Synthesis of N-Benzyl 2,4,6-Collidinium Salts by Electrooxidative C-H Functionalization was written by Motsch, Bill J.;Wengryniuk, Sarah E.. And the article was included in Organic Letters in 2022.Related Products of 105-13-5 This article mentions the following:

The synthesis of benzylic 2,4,6-collidinium salts I (R = Br, 3-chloropropyl, (piperidin-1-yl)carbonyl, etc.; R¹ = Me, Bn, TBS, etc.; R² = R³ = H, Me; R⁴ = Me, Et, propan-2-yl, etc.; R⁴, R³ = -CH₂-CH₂-CH₂-; R⁵ = 2,4,6-trimethyl-pyridin-1-ylium-1-yl-tetrafluoroborate salt, pyridin-1-ylium-1-yl-tetrafluoroborate salt, 2-phenyl-pyridin-1-ylium-1-yl-tetrafluoroborate salt, etc.; X = C, N) via electrooxidative C-H functionalization has been reported . This method provides a complementary approach to traditional strategies relying on substitution and condensation of prefunctionalized substrates. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Related Products of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile Synthesis of Single Iron Atoms over MoS₂ Nanosheets via Spontaneous Reduction for Highly Efficient Selective Oxidation of Alcohols was written by Li, Zhijun;Li, Honghong;Yang, Zening;Lu, Xiaowen;Ji, Siqi;Zhang, Mingyang;Horton, J. Hugh;Ding, Honghe;Xu, Qian;Zhu, Junfa;Yu, Jin. And the article was included in Small in 2022.Formula: C8H10O2 This article mentions the following:

The facile creation of high-performance single-atom catalysts (SACs) is intriguing in heterogeneous catalysis, especially on 2D transition-metal dichalcogenides. An efficient spontaneous reduction approach to access atomically dispersed iron atoms supported over defect-containing MoS₂ nanosheets is herein reported. Advanced characterization methods demonstrate that the isolated iron atoms situate atop of molybdenum atoms and coordinate with three neighboring sulfur atoms. This Fe SAC delivers exceptional catalytic efficiency (1 atm O₂ @ 120鎺? in the selective oxidation of benzyl alc. to benzaldehyde, with 99% selectivity under almost 100% conversion. The turnover frequency is calculated to be as high as 2105 h^-1. Moreover, it shows admirable recyclability, storage stability, and substrate tolerance. D. functional theory calculations reveal that the high catalytic activity stems from the optimized electronic structure of single iron atoms over the MoS2 support. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Formula: C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Blue-light Induced Iron-Catalyzed 浼?Alkylation of Ketones was written by Abdallah, Marie-Samira;Joly, Nicolas;Gaillard, Sylvain;Poater, Albert;Renaud, Jean-Luc. And the article was included in Organic Letters in 2022.Application In Synthesis of (4-Methoxyphenyl)methanol This article mentions the following:

A visible-light induced iron-catalyzed 浼?alkylation of ketones was reported. The photocatalytic system was based on the single diaminocyclopentadienone iron tricarbonyl complex. Two catalytic intermediates of this complex were able to harvest light allowing the synthesis of substituted aromatic and aliphatic ketones such as RC(O)CH₂CH₂R¹ [R = t-Bu, 4-MeC₆H₄, 2-furyl, etc.; R¹ = Ph, 2-thienyl, 4-BrC₆H₄, etc.] at room temperature using the borrowing hydrogen strategy in the presence of various substituted primary alcs. as alkylating reagents. Preliminary mechanistic studies unveiled the role of light for both the dehydrogenation and reduction step. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Application In Synthesis of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application In Synthesis of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem