Category: 10365-98-7

《Binding Interaction Between Boronic Acid Derivatives with Monosaccharaides colon Effect of Structural Change of Monosaccharaides Upon Binding Using S hyphen V Plots》 was published in Macromolecular Symposia in 2020. These research results belong to Bhavya, P.; Melavanki, Raveendra; Narayanappa, C. K.; Kusanur, Raviraj; U., Meghana; B., Suma. Application In Synthesis of 3-Methoxyphenylboronic acid The article mentions the following:

Sugar sensing and continuous monitoring of glucose (CGM) play an important and vital role in controlling diabetes. The present enzyme-based sugar sensors have their own drawbacks. Problems associated with them have encouraged alternate approaches to design new sensors. Among many, fluorescent intensity change based sensors are drawing more attention. Fluorescence sensors based on boronic acid derivatives are more popular because of their ability to reversibly bind diol-containing compounds Here, the binding ability of two boronic acid derivatives, namely 2-methylphenyl boronic acid (B1) and 3-methoxyphenyl boronic acid (B2) with mono saccharides (sugars), is under investigation. The sugar concentration is kept nearly 1000 times more than that of boronic acid. The interactions of B1 and B2 with three saccharides (D-sorbitol, dextrose, and fructose) are studied by absorbance and steady-state fluorescence. Both B1 and B2 fluorescence is quenched by formation of esters with saccharides. The results of absorbance and fluorescence measurements indicate that the studied sugars can be ordered by their affinity to B1 as: D-sorbitol > xylose > dextrose and for B2 as: dextrose > xylose > D-sorbitol. In each case, slope of modified S-V plots is nearly one indicating only a single binding site in boronic acids for sugars. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Application In Synthesis of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Application In Synthesis of 3-Methoxyphenylboronic acid

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Recommanded Product: 3-Methoxyphenylboronic acidIn 2021 ,《Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on GPER as antiproliferative compounds against renal, liver and pancreatic cancer cells》 was published in Pharmaceuticals. The article was written by Mendez-Luna, David; Morelos-Garnica, Loreley Araceli; Garcia-Vazquez, Juan Benjamin; Bello, Martiniano; Padilla-Martinez, Itzia Irene; Fragoso-Vazquez, Manuel Jonathan; Gonzalez, Alfonso Duenas; De Pedro, Nuria; Gomez-Vidal, Jose Antonio; Mendoza-Figueroa, Humberto Lubriel; Correa-Basurto, Jose. The article contains the following contents:

The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective mols. against cancer without side effects. In this study, three new compounds were designed and synthesized with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-tox) properties and high affinity for the G protein-coupled estrogen receptor (GPER) binding site by in silico methods, which correlated with the growth inhibitory activity tested in a cluster of cancer cell lines. Docking and mol. dynamics (MD) simulations accompanied by a mol. mechanics/generalized Born surface area (MMGBSA) approach yielded the binding modes and energetic features of the proposed compounds on GPER. These in silico studies showed that the compounds reached the GPER binding site, establishing interactions with a phenylalanine cluster (F206, F208 and F278) required for GPER mol. recognition of its agonist and antagonist ligands. Finally, a 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay showed growth inhibitory activity of compounds 4, 5 and 7 in three different cancer cell lines-MIA Paca-2, RCC4-VA and Hep G2-at micromolar concentrations These new mols. with specific chem. modifications of the GPER pharmacophore open up the possibility of generating new compounds capable of reaching the GPER binding site with potential growth inhibitory activities against nonconventional GPER cell models.3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 3-Methoxyphenylboronic acid

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《Palladium Nanoparticle-Bentonite Hybrid Using Leaves of Syzygium aqueum Plant from India: Design and Assessment in the Catalysis of -C-C- Coupling Reaction》 was written by Manjare, Satish B.; Chaudhari, Rajendra A.. HPLC of Formula: 10365-98-7 And the article was included in Chemistry Africa in 2020. The article conveys some information:

An environment-friendly synthesis process has been developed with the aid of Syzygium aqueum (water apple) leaves extract Pulverized leaves of Syzygium aqueum (water apple) are mixed with a universal solvent such as water for the preparation of Pd nanoparticle supported on activated bentonite. The extract from the plant leaves acts both as a reducing agent and also as a capping agent for converting the PdCl2 to PdNPs. The synthesized PdNPs are supported on modified clay and they are characterized by using FTIR, BET, HR-TEM, ICP-MS, TGA, XRD, and FE-SEM/EDX. It is found that the supported PdNPs give high rate of conversions of Suzuki-Miyaura coupling products and give greater than 90% products in universal solvent i.e. water at fairly low temperature It shows the potential for the environment-friendly synthesis of prime organic mols. like excellent biaryl derivatives with TONs and TOFs with economical and efficient catalyst loading. We recorded high activity, chemoselectivity and excellent TONs (15,061-20,537) and TOFs (100,407-136,919) by using a small catalyst loading in short reaction time only 15 min. The catalyst shows a long lifetime (ten times). Experiments are performed, recycling it, which demonstrate the sustainability and efficiency of the catalytic process. The prepared catalyst gives a higher percentage of coupling product in the lower time. The supported PdNPs help to form good selectivity and efficacy. The catalyst is found highly stable and can be recycled ten times with no appreciable loss in the efficiency. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

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Wang, Cece; Zhou, Lu; Qiu, Jian; Yang, Kai; Song, Qiuling published an article in 2022. The article was titled 《Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones》, and you may find the article in Organic Chemistry Frontiers.Product Details of 10365-98-7 The information in the text is summarized as follows:

A diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines catalyzed by a Rh(I) catalyst was reported. This reaction provided a practical method to obtain valuable chiral α-amino ketones with excellent diastereoselectivity, featuring operational simplicity, mild reaction conditions and a broad substrate scope. In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Product Details of 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Product Details of 10365-98-7

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Application of 10365-98-7In 2020 ,《Novel formyl peptide receptors (FPRs) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis》 appeared in Bioorganic Chemistry. The author of the article were Crocetti, Letizia; Vergelli, Claudia; Guerrini, Gabriella; Cantini, Niccolo; Kirpotina, Liliya N.; Schepetkin, Igor A.; Quinn, Mark T.; Parisio, Carmen; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Giovannoni, Maria Paola. The article conveys some information:

The resolution of inflammation is an active response involving the interaction of pro-resolving mediators with specific receptors, such as N-formyl peptide receptor 2 (FPR2). FPRs represent potentially important therapeutic targets for the treatment of some pathologies, including asthma and rheumatoid arthritis. Previously, we identified selective or mixed FPR agonists with a pyridazin-3(2H)-one scaffold, all containing a 4-bromophenylacetamide fragment at N-2. The most effective compounds in this series were EC3, a potent mixed FPR1/FPR2/FPR3 agonist, and EC10, which had a preference for FPR1. We report here a new series of pyridinone and pyrimidindione derivatives containing the 4-(bromophenyl)acetamide substituent that was essential for activity in the pyridazinone series. All new compounds were evaluated for FPR agonist activity in HL60 cells transfected with FPR1 or FPR2 and in human neutrophils. While most of the pyridinone derivatives had reasonable FPR agonist activity in the submicromolar/micromolar range, the pyrimidindione derivatives were less active. Compound 2a (N-(4-bromophenyl)-2-[3-cyano-5-(3-methoxyphenyl)-6-methyl-2-oxopyridin-1(2H)-yl]acetamide) was the most active pyridinone derivative and had a 10-fold preference for FPR2 (EC50 = 120 nM) vs. FPR1 (EC50 = 1.6 μM). To assess their therapeutic activity, compounds 2a, EC3, and EC10 were evaluated in vivo using a rat model of rheumatoid arthritis. All three compounds increased the pain threshold and reduced pain hypersensitivity in the treated rats vs. control rats, although 2a and EC10 were much more effective than EC3. Thus, these FPR agonists represent potential leads to develop for the treatment of inflammatory diseases such as rheumatoid arthritis. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Application of 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Application of 10365-98-7

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In 2019,Journal of Organic Chemistry included an article by Liu, Shuai; Xu, Liang; Wei, Yu. Synthetic Route of C7H9BO3. The article was titled 《One-Pot, Multistep Reactions for the Modular Synthesis of N,N’-Diarylindazol-3-ones》. The information in the text is summarized as follows:

The pot-economic synthesis of N,N’-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atm. affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

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《Synthesis of a carbon-11 radiolabeled BACE1 inhibitor》 was published in Medicinal Chemistry Research in 2020. These research results belong to Zhu, Yiwei; Fiedler, Stephanie A.; Hibert, Matthew L.; Wang, Changning. Reference of 3-Methoxyphenylboronic acid The article mentions the following:

Beta-secretase (BACE1), a transmembrane aspartyl protease, can cleave membrane-bound β-amyloid precursor proteins (APPs) to initiate the accumulation of amyloid-β (Aβ). The inhibition of BACE-1 to limit the accumulation of neurotoxic Aβ peptides could offer a potential treatment for Alzheimer’s Disease (AD). However, little is known about the distribution and d. of BACE1 in the central nervous system. As a step toward filling this gap in knowledge, we have evaluated a potential radiotracer for the imaging of BACE1 using positron emission tomog. (PET). A BACE1 inhibitor, 5, is reported with blood-brain barrier (BBB) permeability and high binding affinity. To characterize the pharmacokinetics and distribution of 5 in the brain, we radiolabeled 5 with carbon-11. Using PET, we found that [11C]5 shows moderate uptake in the brain when administered i.v. to rodents and further work will be performed in animal models to test its application as a PET imaging probe for the central nervous system. Our study demonstrates the effectiveness of PET at providing brain pharmacokinetic data for BACE1 inhibitors, crucial for the development of treatments for AD where CNS penetration is critical3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

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《Natural carbolines inspired the discovery of chiral CarOx ligands for asymmetric synthesis and antifungal leads》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Lai, Jixing; Li, Wei; Wei, Sanyue; Li, Shengkun. Synthetic Route of C7H9BO3 The article mentions the following:

The unprecedented β-CarOx ligands were conceived by the hybridization of alangiobussinine and the privileged pyridine-oxazoline scaffold. It is well performed in the highly enantioselective Pd-catalyzed Michael addition of arylboronic acids to nitrostyrenes and β-substituted cyclic enone (up to 99% ee). The β-CarOx ligands also showed an enhanced antifungal effect compared to alangiobussinine, demonstrating promising antifungal leads against Sclerotinia sclerotiorum. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

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Ether – Wikipedia,
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《meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester》 was written by Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J.. Formula: C7H9BO3 And the article was included in Chemical Science in 2020. The article conveys some information:

N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Formula: C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Formula: C7H9BO3

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Chen, Wangchao; Zhang, Hanyu; Sun, Jianjun; Ghadari, Rahim; Zhang, Zhengguo; Pan, Fei; Lv, Kai; Sun, Xun; Guo, Fuling; Shi, Chengwu published an article in 2021. The article was titled 《Molecular tailor-making of zinc phthalocyanines as dopant-free hole-transporting materials for efficient and stable perovskite solar cells》, and you may find the article in Journal of Power Sources.Synthetic Route of C7H9BO3 The information in the text is summarized as follows:

Four Zinc (II) phthalocyanines (ZnPcs) derivatives, ZnPH13, ZnPH14, ZnPH15 and ZnPH22, decorated with elaborate mol. tailor-making on the phenyl-based peripheral substituents of Pc scaffolds are synthesized and acted as dopant-free hole-transporting materials (HTMs) in perovskite solar cells (PSCs). The detailed electrochem., photophys. characteristics, theor. geometric/electronic features, hole mobility, charge carrier extraction, collection and transporting dynamic processes of these HTMs are cautiously unveiled. The heuristic probe into the substantial relations and dependences between the Pc organic scaffold structure and properties at mol. level are investigated. The mixed-ion PSC utilizing the ZnPH22 containing the benzo[d] [1,3]dioxole peripheral substituent with cyclic/planar conformation presents a most competitive power conversion efficiency (PCE) of 18.3% associating with excellent reproducibility and superior long-period stability. These results reveal that the eventual solar cell performance can be decipherable through the intrinsic electronic and structural effects originating from the peripheral substituents modifications. This work thus exploits the new insights into the advanced mol. building of efficient phthalocyanines HTMs for high performance and stable PSCs. In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem