Category: 103-16-2

Efficient hydrodeoxygenation of phenolic compounds and raw lignin-oil under a temperature-controlled phase-transfer catalysis was written by Yang, Zhi;Luo, Bowen;Shu, Riyang;Tian, Zhipeng;Kang, Yu;Chen, Ying. And the article was included in Fuel in 2021.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

An effective binary catalyst by using tungstic acid (H₂WO₄) and Ru/C was employed for the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin-oil. H2WO4 was presented as solid at ambient temperature, but it dissolved at high temperature above 100°C and therefore functioned as an active homogeneous catalyst. This phenomenon resulted in a temperature-controlled phase-transfer behavior in the HDO of phenolic compounds An efficient HDO performance and an exceptional reusability for guaiacol HDO were presented by this bifunctional catalyst, which can be reused more than 10 times with guaiacol conversion and cyclohexane selectivity over 90%. The comparison of traditional liquid organic and mineral acids, as well as solid acids, with H₂WO₄ confirmed the outstanding catalytic performance of H₂WO₄ and highlighted the advantages of H₂WO₄ as a homogeneous catalyst. Besides guaiacol, other phenolic compounds including various monomers and dimers all exhibited good HDO results, with 100% conversion and cycloalkanes selectivity. Moreover, the raw lignin-oil can be efficiently deoxygenated under the catalysis of this bifunctional catalyst 99.3% content of hydrocarbons was obtained in the upgraded lignin-oil, which was promising to be used as fuel directly. This catalytic system has great potential for the industrial application of lignin-oil upgrade. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient hydrodeoxygenation of phenolic compounds and raw lignin-oil under a temperature-controlled phase-transfer catalysis was written by Yang, Zhi;Luo, Bowen;Shu, Riyang;Tian, Zhipeng;Kang, Yu;Chen, Ying. And the article was included in Fuel in 2021.Electric Literature of C13H12O2 The following contents are mentioned in the article:

An effective binary catalyst by using tungstic acid (H₂WO₄) and Ru/C was employed for the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin-oil. H2WO4 was presented as solid at ambient temperature, but it dissolved at high temperature above 100°C and therefore functioned as an active homogeneous catalyst. This phenomenon resulted in a temperature-controlled phase-transfer behavior in the HDO of phenolic compounds An efficient HDO performance and an exceptional reusability for guaiacol HDO were presented by this bifunctional catalyst, which can be reused more than 10 times with guaiacol conversion and cyclohexane selectivity over 90%. The comparison of traditional liquid organic and mineral acids, as well as solid acids, with H₂WO₄ confirmed the outstanding catalytic performance of H₂WO₄ and highlighted the advantages of H₂WO₄ as a homogeneous catalyst. Besides guaiacol, other phenolic compounds including various monomers and dimers all exhibited good HDO results, with 100% conversion and cycloalkanes selectivity. Moreover, the raw lignin-oil can be efficiently deoxygenated under the catalysis of this bifunctional catalyst 99.3% content of hydrocarbons was obtained in the upgraded lignin-oil, which was promising to be used as fuel directly. This catalytic system has great potential for the industrial application of lignin-oil upgrade. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubility of monobenzone in aqueous co-solvent mixtures of several alcohols: Determination, modelling and thermodynamic aspects analysis was written by Zhou, Yanyan;Wu, Jiaxin;Farajtabar, Ali;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2020.Reference of 103-16-2 The following contents are mentioned in the article:

Investigation upon the solubility of monobenzone in aqueous co-solvent mixtures of isopropanol, n-propanol, ethylene glycol (EG) and ethanol was performed via a saturation shake-flask technique at temperatures from 283.15 K to 328.15 K under pressure of p = 101.2 kPa. Exptl. solubility magnitude presented pos. dependence upon the mass fraction of each co-solvent and temperature The greatest solubility value on the mole fraction scale was observed in the neat co-solvents. The equilibrated solids with corresponding co-solvent mixtures were characterized through an X-ray power diffraction (XRD) technique, demonstrating the absence of polymorphic transformation or solvate formation. The Jouyban-Acree model was adopted to math. describe the monobenzone solubility data. The maximum magnitudes of RAD and RMSD were 3.17 × 10^-2 and 7.64 × 10^-4, resp. The local mole fractions of isopropanol (n-propanol, EG or ethanol) and water adjacent monobenzone were quant. studied by the Inverse Kirkwood-Buff integrals method. The parameters of preferential solvation for the isopropanol (n-propanol, EG or ethanol) were pos. in the isopropanol (n-propanol, EG or ethanol) mixtures in intermediate and alc.-rich compositions, indicating that monobenzone was preferentially solvated by the isopropanol (n-propanol, EG or ethanol). Monobenzone mainly acted as a Lewis acid which interacted with proton-acceptor functional group of the alcs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 103-16-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubility of monobenzone in aqueous co-solvent mixtures of several alcohols: Determination, modelling and thermodynamic aspects analysis was written by Zhou, Yanyan;Wu, Jiaxin;Farajtabar, Ali;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Investigation upon the solubility of monobenzone in aqueous co-solvent mixtures of isopropanol, n-propanol, ethylene glycol (EG) and ethanol was performed via a saturation shake-flask technique at temperatures from 283.15 K to 328.15 K under pressure of p = 101.2 kPa. Exptl. solubility magnitude presented pos. dependence upon the mass fraction of each co-solvent and temperature The greatest solubility value on the mole fraction scale was observed in the neat co-solvents. The equilibrated solids with corresponding co-solvent mixtures were characterized through an X-ray power diffraction (XRD) technique, demonstrating the absence of polymorphic transformation or solvate formation. The Jouyban-Acree model was adopted to math. describe the monobenzone solubility data. The maximum magnitudes of RAD and RMSD were 3.17 × 10^-2 and 7.64 × 10^-4, resp. The local mole fractions of isopropanol (n-propanol, EG or ethanol) and water adjacent monobenzone were quant. studied by the Inverse Kirkwood-Buff integrals method. The parameters of preferential solvation for the isopropanol (n-propanol, EG or ethanol) were pos. in the isopropanol (n-propanol, EG or ethanol) mixtures in intermediate and alc.-rich compositions, indicating that monobenzone was preferentially solvated by the isopropanol (n-propanol, EG or ethanol). Monobenzone mainly acted as a Lewis acid which interacted with proton-acceptor functional group of the alcs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic transfer hydrogenolysis of lignin α-O-4 model compound 4-(benzyloxy)phenol and lignin over Pt/HNbWO₆/CNTs catalyst was written by Guan, Weixiang;Chen, Xiao;Zhang, Jie;Hu, Haoquan;Liang, Changhai. And the article was included in Renewable Energy in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

Cleavage of C-O bonds in aryl ether through the catalytic transfer hydrogenolysis (CTH) is an encouraging method for the valorization of lignin into fine chems. and liquid fuels. In this contribution, the CTH of typical lignin α-O-4 model compound 4-(benzyloxy)phenol (BOP) and lignin extracted from ash wood have been explored over 0.45 wt% Pt/HNbWO₆/CNTs catalyst. The effect of solvents was elaborated and the highest catalytic activity was achieved in the CTH of BOP using isopropanol as the solvent (98.1%). This was because isopropanol can provide more hydrogen atoms to promote CTH reaction due to the weakest interaction between isopropanol and BOP among all H-donor solvents. The favorable results obtained in the model compound study inspired us to afford Pt/HNbWO₆/CNTs catalyst in the CTH of lignin. The relative oxygen content of lignin was sharply decreased after the CTH process, and the higher heating value (HHV) significantly increased from 21.4 MJ/kg to 30.8 MJ/kg. GPC, FT-IR, GC-MS, and 2D-NMR results revealed that lignin was successfully depolymerized into small mol. compounds over Pt/HNbWO₆/CNTs catalyst through the CTH process. Thereinto, phenolic compounds were the major components in the liquid products in which most of them were monophenols. The results obtained in this work shed light on that Pt/HNbWO₆/CNTs was a favorable catalyst in the depolymerization of lignin into valuable phenolic compounds via the CTH method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic transfer hydrogenolysis of lignin α-O-4 model compound 4-(benzyloxy)phenol and lignin over Pt/HNbWO₆/CNTs catalyst was written by Guan, Weixiang;Chen, Xiao;Zhang, Jie;Hu, Haoquan;Liang, Changhai. And the article was included in Renewable Energy in 2020.Safety of 4-Benzyloxyphenol The following contents are mentioned in the article:

Cleavage of C-O bonds in aryl ether through the catalytic transfer hydrogenolysis (CTH) is an encouraging method for the valorization of lignin into fine chems. and liquid fuels. In this contribution, the CTH of typical lignin α-O-4 model compound 4-(benzyloxy)phenol (BOP) and lignin extracted from ash wood have been explored over 0.45 wt% Pt/HNbWO₆/CNTs catalyst. The effect of solvents was elaborated and the highest catalytic activity was achieved in the CTH of BOP using isopropanol as the solvent (98.1%). This was because isopropanol can provide more hydrogen atoms to promote CTH reaction due to the weakest interaction between isopropanol and BOP among all H-donor solvents. The favorable results obtained in the model compound study inspired us to afford Pt/HNbWO₆/CNTs catalyst in the CTH of lignin. The relative oxygen content of lignin was sharply decreased after the CTH process, and the higher heating value (HHV) significantly increased from 21.4 MJ/kg to 30.8 MJ/kg. GPC, FT-IR, GC-MS, and 2D-NMR results revealed that lignin was successfully depolymerized into small mol. compounds over Pt/HNbWO₆/CNTs catalyst through the CTH process. Thereinto, phenolic compounds were the major components in the liquid products in which most of them were monophenols. The results obtained in this work shed light on that Pt/HNbWO₆/CNTs was a favorable catalyst in the depolymerization of lignin into valuable phenolic compounds via the CTH method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Safety of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer was written by Bai, Chengfeng;Ren, Shengnan;Wu, Shuangjie;Zhu, Meiqi;Luo, Guoshun;Xiang, Hua. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

Endocrine therapy (ET) has benefited patients with estrogen receptor alpha (ERα) pos. breast cancer for decades. Selective estrogen receptor modulator (SERM) such as Tamoxifen represents the clin. standard of care (SoC). Despite the therapeutic importance of current SoC agents, 30-50% of prolonged treatment patients inevitably generated resistant tumor cells, usually eventually suffered tumor relapse and developed into metastatic breast cancer (MBC), which was the leading cause of female cancer-related mortality. Among these, most resistant tumors remained dependent on ERα signaling, which reignited the need for the next generation of ERα related agents. Authors hypothesized that selective estrogen receptor covalent antagonists targeting ERα would provide a therapeutic alternative. In the current work, series of novel benzothiophene hybrids I (R₁ = H, Me; R₂ = Me; R₁R₂ = (CH₂)₃, (CH₂)₅, etc.) II, III (R₃ = R₄ = H, Me) and IV bearing electrophile moieties were synthesized and biol. evaluated. The representative analog I (R₁R₂ = (CH₂)₃) exhibited potent anti-proliferative effect in MCF-7 cell lines in vitro, and further mechanism studies confirmed the necessity of covalent bonding. More importantly, I could attenuate the expression of TFF-1, GREB-1 and down-regulate the levels of cellular ERα protein. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification of p53 Activators in a Human Microarray Compendium was written by Corton, J. Christopher;Witt, Kristine L.;Yauk, Carole L.. And the article was included in Chemical Research in Toxicology in 2019.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

Biomarkers predictive of mol. and toxicol. effects are needed to interpret emerging high-throughput transcriptomic data streams. The previously characterized 63 gene TGx-DDI biomarker that includes 20 genes known to be regulated by p53 was previously shown to accurately predict DNA damage in chem.-treated cells. The authors comprehensively evaluated whether the mol. basis of the DDI predictions was based on a p53-dependent response. The biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. Using the biomarker, the authors identified conditions that led to p53 activation, including exposure to the chem. nutlin-3 which disrupts interactions between p53 and the neg. regulator MDM2 or by knockdown of MDM2. The expression of most of the genes in the biomarker (75%) were found to depend on p53 activation status based on gene behavior after TP53 overexpression or knockdown. The biomarker identified DDI chems. that were strong inducers of p53 in wild-type cells; these p53 responses were decreased or abolished in cells after p53 knockdown by siRNAs. Using the biomarker, the authors screened ∼1950 chems. in ∼9800 human cell line chem. vs. control comparisons and identified ∼100 chems. that caused p53 activation. Among the pos. chems. were many that are known to activate p53 through direct and indirect DNA damaging mechanisms. These results contribute to the evidence that the TGx-DDI biomarker is useful for identifying chems. that cause DDI and activate p53. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents was written by Kazui, Yuko;Fujii, Shinya;Yamada, Ayumi;Ishigami-Yuasa, Mari;Kagechika, Hiroyuki;Tanatani, Aya. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Application of 103-16-2 The following contents are mentioned in the article:

The androgen receptor (AR) is a ligand-inducible transcription factor belonging to the nuclear receptor superfamily, and is a target mol. for development of drugs to treat prostate cancer. However, AR antagonists in clin. use, such as flutamide (3a) and bicalutamide (4), encounter resistance after several years of hormone therapy, predominantly due to mutations of AR. Thus, although some new-generation AR antagonists have been developed, novel types of AR antagonists are still required to treat drug-resistant prostate cancer. We previously reported a novel (benzoylaminophenoxy)phenol derivative 10a, which is structurally distinct from conventional AR antagonists. Here, we systematically examined the structure-activity relationship of (benzoylaminophenoxy)phenol derivatives on the inhibitory activity on the prostate cancer cell proliferations. We found that the 4-[4-(benzoylamino)phenoxy]phenol backbone is important for anti-prostate cancer activity. Introduction of a small substituent at the 2 position of the central benzene ring (B ring) increases the activity. Among the synthesized compounds, 19a and 19b exhibited the most potent inhibitory activity toward dihydrotestosterone-induced proliferation of several androgen-dependent cell lines, SC-3 (wild-type AR), LNCaP (T877A AR), and 22Rv1 (H874Y AR), but interestingly also inhibited proliferation of AR-independent PC-3 cells. These compounds, which have a different pharmacophore from conventional AR antagonists, are promising drug candidates for the treatment of prostate cancer. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The recovery of strontium from acidic medium using novel strontium selective extractant: an experimental and DFT study was written by Khan, Pasupati Nath;Bhattacharyya, A.;Sharma, J. N.;Manohar, S.. And the article was included in Journal of Hazardous Materials in 2020.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

In view of the limited solvent system known for the Sr²⁺ extraction from acidic media, extraction and recovery of ⁹⁰Sr from acidic medium using novel Octabenzyloxyoctakis[[[((N,N-diethylamino)carbonyl)]methyl]oxy]calix[8]arene (BOC8A) extractant in nitro alkane medium are presented.. BOC8A and nitro alkanes have been synthesized and characterized by ¹H NMR, ¹³C NMR, FTIR and GC-MS techniques. Solvent composition of 0.01 M BOC8A in nitro octane (NO) has been optimized for substantial amount of extraction of strontium from feed acidity of 3.5-4 M nitric acid, (D_{3.5-4 M HNO3} = 7.1-7.8). Poor extraction of Pu⁴⁺, Ba²⁺, Na⁺ and UO₂⁺² and negligible extraction of Am³⁺, Cs⁺, Ru³⁺, Nd³⁺, Zr²⁺ and trivalent lanthanides are observed Ion dissociation mechanism was found to be operative involving an extractable complex having Sr²⁺, BOC8A and HNO₃ in a ratio of 1:1:2. About 99% of Sr²⁺ from the loaded solvent was recovered with 0.01 M HNO₃. DFT calculations were used to predict the structures of free, protonated BOC8A and its complex with Sr²⁺. DFT result showed reorientation in conformation of BOC8A due to protonation resulting in the Sr²⁺ extraction from acidic medium with significantly high interaction energy between Sr²⁺ and diprotonated form of BOC8A. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem