Category: 103-16-2

Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage was written by Zhu, Zhaodong;Gong, Yuxin;Tong, Weiqi;Xue, Weichao;Gong, Hegui. And the article was included in Organic Letters in 2021.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

A synthesis of aryl thioesters RCOSR¹ (R = Ph, 4-MeO₂CC₆H₄, 4-BnOC₆H₄, etc.; R¹ = n-hexyl, cyclohexyl, cyclopentyl, etc.) via nickel-catalyzed reductive coupling of aryl triflates with thiocarbonates was reported. Both electron-rich and -deficient aryl C(sp²)-O electrophiles as well as a class of O-tBu S-alkyl thiocarbonates were compatible with the optimized reaction conditions as evidenced by 49 examples. The reaction also proceeded with good chemoselective cleavage of the C-O bond with regard to thioesters. This work broadened the scope of nickel-catalyzed reductive cross-electrophile coupling reactions. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage was written by Zhu, Zhaodong;Gong, Yuxin;Tong, Weiqi;Xue, Weichao;Gong, Hegui. And the article was included in Organic Letters in 2021.Computed Properties of C13H12O2 The following contents are mentioned in the article:

A synthesis of aryl thioesters RCOSR¹ (R = Ph, 4-MeO₂CC₆H₄, 4-BnOC₆H₄, etc.; R¹ = n-hexyl, cyclohexyl, cyclopentyl, etc.) via nickel-catalyzed reductive coupling of aryl triflates with thiocarbonates was reported. Both electron-rich and -deficient aryl C(sp²)-O electrophiles as well as a class of O-tBu S-alkyl thiocarbonates were compatible with the optimized reaction conditions as evidenced by 49 examples. The reaction also proceeded with good chemoselective cleavage of the C-O bond with regard to thioesters. This work broadened the scope of nickel-catalyzed reductive cross-electrophile coupling reactions. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The first synthesis and immunomodulatory properties of p-hydroxyphenyl caffeate derived from Wedelia trilobata was written by Yang, Jisu;Yoon, Jeong A.;Kim, Kwangmi;Han, Young Taek. And the article was included in Journal of Asian Natural Products Research in 2020.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Herein, we report a concise and efficient method for the synthesis of p-hydroxyphenyl caffeate, a novel natural caffeic acid ester derivative isolated from Wedelia trilobata. The key feature of this synthesis is the Verley-Doebner modification of the Knoevenagel condensation of the p-hydroxyphenyl malonate intermediate. The synthesized p-hydroxyphenyl caffeate enhanced interleukin 2 production by murine lymph node T cells, and suppressed interleukin 13 production by murine epidermal T cells. This implies that p-hydroxyphenyl caffeate might be a novel immunomodulatory drug candidate, specifically targeting T helper 2 cell type responses in skin diseases such as atopic dermatitis and vitiligo. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The first synthesis and immunomodulatory properties of p-hydroxyphenyl caffeate derived from Wedelia trilobata was written by Yang, Jisu;Yoon, Jeong A.;Kim, Kwangmi;Han, Young Taek. And the article was included in Journal of Asian Natural Products Research in 2020.Reference of 103-16-2 The following contents are mentioned in the article:

Herein, we report a concise and efficient method for the synthesis of p-hydroxyphenyl caffeate, a novel natural caffeic acid ester derivative isolated from Wedelia trilobata. The key feature of this synthesis is the Verley-Doebner modification of the Knoevenagel condensation of the p-hydroxyphenyl malonate intermediate. The synthesized p-hydroxyphenyl caffeate enhanced interleukin 2 production by murine lymph node T cells, and suppressed interleukin 13 production by murine epidermal T cells. This implies that p-hydroxyphenyl caffeate might be a novel immunomodulatory drug candidate, specifically targeting T helper 2 cell type responses in skin diseases such as atopic dermatitis and vitiligo. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Concentration-dependent supramolecular self-assembly of A1/A2-asymmetric-difunctionalized pillar[5]arene was written by Al-Azemi, Talal F.;Vinodh, Mickey. And the article was included in RSC Advances in 2021.Related Products of 103-16-2 The following contents are mentioned in the article:

A series of A1/A2-bromoalkoxy-and-hydroxy-difunctionalized pillar[5]arenes were synthesized by the removal of the pillar[5]arene-bearing benzyl group using catalytic hydrogenation. The difunctionalized pillar[5]arene bearing 8-bromooctoxy and benzyloxy substituents at the A1/A2 positions formed pseudo[1]rotaxane at low concentration and double-threaded supramol. dimer at high concentration The supramol. self-assembly behavior has been probed with multiple methods including varying (variable) concentration ¹H NMR spectroscopy, diffusion-ordered spectroscopy (DOSY), dynamic light scattering (DLS) measurements, isothermal titration calorimetry (ITC), and single-crystal X-ray anal. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Concentration-dependent supramolecular self-assembly of A1/A2-asymmetric-difunctionalized pillar[5]arene was written by Al-Azemi, Talal F.;Vinodh, Mickey. And the article was included in RSC Advances in 2021.Application of 103-16-2 The following contents are mentioned in the article:

A series of A1/A2-bromoalkoxy-and-hydroxy-difunctionalized pillar[5]arenes were synthesized by the removal of the pillar[5]arene-bearing benzyl group using catalytic hydrogenation. The difunctionalized pillar[5]arene bearing 8-bromooctoxy and benzyloxy substituents at the A1/A2 positions formed pseudo[1]rotaxane at low concentration and double-threaded supramol. dimer at high concentration The supramol. self-assembly behavior has been probed with multiple methods including varying (variable) concentration ¹H NMR spectroscopy, diffusion-ordered spectroscopy (DOSY), dynamic light scattering (DLS) measurements, isothermal titration calorimetry (ITC), and single-crystal X-ray anal. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The catalytic decarboxylative allylation of enol carbonates: the synthesis of enantioenriched 3-allyl-3′-aryl 2-oxindoles and the core structure of azonazine was written by Babu, K. Naresh;Pal, Souvik;Khatua, Arindam;Roy, Avishek;Bisai, Alakesh. And the article was included in Organic & Biomolecular Chemistry in 2022.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

The catalytic asym. synthesis of 3-allyl-3’aryl 2-oxindoles I [Ar = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, 2-(benzyloxy)-5-methylbenzen-1-yl, etc.; R = Me, Bn, allyl, X = H, 5-Br, 5-Cl, 5-OMe, 7-Me] has been shown via the Pd(0)-catalyzed decarboxylative allylation of allylenol carbonates. This methodol. provides access to a variety of 2-oxindole substrates I with all-carbon quaternary stereocenters (up to 94% ee) at the pseudobenzylic position under additive-free and mild conditions. The synthetic potential of this method was shown by the asym. synthesis of the tetracyclic core of the diketopiparazine-based alkaloid azonazine II. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The catalytic decarboxylative allylation of enol carbonates: the synthesis of enantioenriched 3-allyl-3′-aryl 2-oxindoles and the core structure of azonazine was written by Babu, K. Naresh;Pal, Souvik;Khatua, Arindam;Roy, Avishek;Bisai, Alakesh. And the article was included in Organic & Biomolecular Chemistry in 2022.Reference of 103-16-2 The following contents are mentioned in the article:

The catalytic asym. synthesis of 3-allyl-3’aryl 2-oxindoles I [Ar = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, 2-(benzyloxy)-5-methylbenzen-1-yl, etc.; R = Me, Bn, allyl, X = H, 5-Br, 5-Cl, 5-OMe, 7-Me] has been shown via the Pd(0)-catalyzed decarboxylative allylation of allylenol carbonates. This methodol. provides access to a variety of 2-oxindole substrates I with all-carbon quaternary stereocenters (up to 94% ee) at the pseudobenzylic position under additive-free and mild conditions. The synthetic potential of this method was shown by the asym. synthesis of the tetracyclic core of the diketopiparazine-based alkaloid azonazine II. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

B(C₆F₅)₃-Catalyzed Hydroarylation of Aryl Alkynes for the Synthesis of 1,1-Diaryl and Triaryl Substituted Alkenes was written by Chen, Hui;Gao, Liuzhou;Liu, Xueting;Wang, Guoqiang;Li, Shuhua. And the article was included in European Journal of Organic Chemistry in 2021.Electric Literature of C13H12O2 The following contents are mentioned in the article:

A new strategy for the synthesis of 1,1-diaryl and triaryl-substituted alkenes was developed utilizing B(C₆F₅)₃-catalyzed hydroarylation of alkynes with phenols. The method provided a direct route to ortho-alkenylated phenols with both terminal and internal alkynes. The reactions showed excellent regioselectivity and good stereoselectivity were observed for the hydroarylation of internal alkynes. Computational and exptl. studies suggested that for the reaction of internal alkynes and phenols, an acid-catalyzed isomerization mechanism involving two tertiary carbonium ion intermediates was responsible for the formation of Z-triaryl substituted alkenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

B(C₆F₅)₃-Catalyzed Hydroarylation of Aryl Alkynes for the Synthesis of 1,1-Diaryl and Triaryl Substituted Alkenes was written by Chen, Hui;Gao, Liuzhou;Liu, Xueting;Wang, Guoqiang;Li, Shuhua. And the article was included in European Journal of Organic Chemistry in 2021.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

A new strategy for the synthesis of 1,1-diaryl and triaryl-substituted alkenes was developed utilizing B(C₆F₅)₃-catalyzed hydroarylation of alkynes with phenols. The method provided a direct route to ortho-alkenylated phenols with both terminal and internal alkynes. The reactions showed excellent regioselectivity and good stereoselectivity were observed for the hydroarylation of internal alkynes. Computational and exptl. studies suggested that for the reaction of internal alkynes and phenols, an acid-catalyzed isomerization mechanism involving two tertiary carbonium ion intermediates was responsible for the formation of Z-triaryl substituted alkenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem