10075-63-5 Archives - Ethers-buliding-blocks

Continuously updated synthesis method about C12H12O2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dimethoxynaphthalene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 10075-63-5, name is 1,5-Dimethoxynaphthalene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10075-63-5, Safety of 1,5-Dimethoxynaphthalene

General procedure: To [Ir(COD)OMe]2 (7.3 mg, 11 mumol) and 4,4′-di-tert-butyl-2,2′-bipyridine (7.0 mg, 26 mumol) in a flame-dried vial under nitrogen were added THF (0.7 mL), pinacolborane (0.18 mL, 1.24 mmol) and 1,4-dimethoxynaphthalene (7) (188 mg, 1.0 mmol). The mixture was stirred at 80 C for 24 h then filtered through Celite and concentrated in vacuo to afford crude pinacol ester 13 (100% conversion by 1H NMR) that was used directly in the next step.

Reference:
Article; Hume, Paul; Furkert, Daniel P.; Brimble, Margaret A.; Tetrahedron Letters; vol. 53; 29; (2012); p. 3771 – 3773;,
Ether – Wikipedia,
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Application of C12H12O2

The synthetic route of 10075-63-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10075-63-5, name is 1,5-Dimethoxynaphthalene, A new synthetic method of this compound is introduced below., Recommanded Product: 10075-63-5

70% Nitric acid (4.5 mL) in acetic acid (4.5 mL) was added slowly to a stirred suspension of 1,5-dimethoxynaphthalene(3.76 g, 20 mmol) in acetic acid (50 mL)at room temperature. Upon stirring overnight at ambienttemperature, the precipitate was filtered off,washed with water, recrystallized from methanol, anddried. Light yellow solid, yield 82%. 1H NMRspectrum, delta, ppm: 3.91 s (6H), 7.31 d (J = 8.5 Hz, 2H), 8.01 d (J = 8.5 Hz, 2H). 13C NMR spectrum, delta, ppm:57.45, 107.87, 116.85, 124.51, 140.69, 155.01.

The synthetic route of 10075-63-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dong; Zhang; Huang; Meng; Li; Russian Journal of General Chemistry; vol. 87; 4; (2017); p. 837 – 841; Zh. Obshch. Khim.; vol. 87; 4; (2017); p. 837 – 841,5;,
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Some scientific research about 10075-63-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

70% Nitric acid (1.5 mL) in acetic acid (1.5 mL) was addedslowly to a stirred suspension of 1,5-dimethoxynaphthalene(3.76 g, 20 mmol) in acetic acid (50 mL) at room temperature. Upon stirring overnight atambient temperature, the precipitate was filtered offand washed with water. The crude product wasrecrystallized from methanol and dried. Light yellowsolid, yield 85%. 1H NMR spectrum, delta, ppm: 3.92 s(3H), 4.03 s (3H), 6.74 d (J = 8.3 Hz, 1H), 7.01 d (J =7.8 Hz, 1H), 7.44-7.53 m (2H), 7.90 d (J = 8.5 Hz,1H). 13C NMR spectrum, delta, ppm: 56.03, 56.06, 102.24,108.31, 114.68, 117.16, 121.65, 127.15, 127.21,141.18, 153.64, 157.04.

The important role of C12H12O2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethoxynaphthalene, its application will become more common.

Reference of 10075-63-5,Some common heterocyclic compound, 10075-63-5, name is 1,5-Dimethoxynaphthalene, molecular formula is C12H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

9.5 g of Intermediate 1-1 was dissolved in 150 ml of acetonitrile, and 8.9 g of N-bromosuccinimide was slowly dropwise added thereto at 0 C. for 10 minutes. The reaction mixture was slowly heated from 0 C. to ambient temperature for 4 hours, and the reaction was terminated by adding water. The reaction mixture was distilled under a reduced pressure, and the residue was subjected to extraction three times using ethyl acetate. The resultant was dried using anhydrous magnesium sulfate and distilled under a reduced pressure, and the residue was separately purified using silica gel column chromatography to obtain 12.9 g of Intermediate 1-2 (Yield: 93%).

Reference:
Patent; Samsung Display Co., Ltd.; Kim, Jong Woo; Kim, Young Guk; Im, Jin Oh; Hwang, Suk Hwan; Kim, Hyung Guen; (58 pag.)KR2015/104678; (2015); A;,
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Introduction of a new synthetic route about 10075-63-5

To a suspensionof 1,5-dimethoxy-naphthalene (3.76 g, 20 mmol)in acetonitrile (50 mL) was added NBS (3.9 g,22 mmol) at room temperature. Upon stirring for 2 h,the precipitate was filtered off and washed with acetonitrile thus giving the crude product which wasrecrystallized from methanol and dried. Cyan-bluesolid, yield 88%. 1H NMR spectrum, delta, ppm: 3.85 s(3H), 3.90 s (3H), 6.74-7.13 m (2H), 7.29-7.48 m(1H), 7.54-7.87 m (2H). 13C NMR spectrum, delta, ppm:55.51, 55.72, 105.05, 107.99, 108.26, 114.92, 125.94,128.76, 132.23, 133.67, 154.69, 155.48.

The important role of C12H12O2

Application of 10075-63-5,Some common heterocyclic compound, 10075-63-5, name is 1,5-Dimethoxynaphthalene, molecular formula is C12H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1Og (0.05mol) of the 1,5-dimethoxynaphthalene, synthesized in PreparationExample 1-1, was dissolved in 160 ml of acetonitrile in a 1,000 ml round-bottom flask. A solution of 21g (0.12mol) of N-bromosuccinimide (NBS) in 180ml of acetonitrile was droplet added to the flask with stirring. After stirring at room temperature for 3 hours, the vacuum filtration of the reaction mixture formed precipitates which were washed with acetonitrile and then twice with hexane and dried to give 12.7 g of the title compound as white power. The properties of the product are as described below.[112][113] Yield: 69.02%, m.p.: 187-188 0C[114] Rf: 0.20 [hexane:ethylacetate(50: 1)][115] IH-NMR (CDCl , 400MHz): delta 7.68(d, J=8.4Hz, 2H), 6.72(d, J=8.4Hz, 2H), 3.91(s,6H)

Reference:
Patent; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; WO2008/18645; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sources of common compounds: 10075-63-5

The synthetic route of 1,5-Dimethoxynaphthalene has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 10075-63-5, name is 1,5-Dimethoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C12H12O2

Methansulfonate 17. 5 part pentoxide diphosphorus 1. 75 part is added, with stirring at 23 C 30 minutes. The mixture obtained, eq. (I-44-a) compound represented by 3. 49 part is prepared, and then, is cooled to 0 C, eq. (I-44-b) compound represented by 5. 5 portion 92 by applying a dropped. After 20 minutes under stirring 0 C, further 23 C 18 at a time. The obtained reaction liquid is cooled to 0 C, ion exchange water 27. 03 part stocking, thereafter, 28% ammonia water 11. 07 by adding a neutralizing, represented by soln. contg. eq. (I-56) is obtained. A solution containing a salt eq. (I-56), eq. (I-44-c) compound represented by 7. 90 part and chloroform 78. 96 by adding, 24 hours at 23 C, a liquid. The organic layer, 40 parts of ion-exchanged water to mixing, stirring, liquid. This flush to 5 times. The organic layer, activated carbon 1. 00 part a, 30 minutes stirring at 23 C, filtration. The filtered liquid is concentrated, obtd. tert-butyl methyl ether 80 to the residue aminoacetonitrile 3 part is added and part, by concentrating the supernatant liquid is removed, the salt 7 eq. (I-44). 83 part is obtained.

The synthetic route of 1,5-Dimethoxynaphthalene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; ANRYU, YUKAKO; ICHIKAWA, KOJI; YOSHIDA, MASAFUMI; (86 pag.)JP2015/143208; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New learning discoveries about 10075-63-5

The synthetic route of 1,5-Dimethoxynaphthalene has been constantly updated, and we look forward to future research findings.

Related Products of 10075-63-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10075-63-5, name is 1,5-Dimethoxynaphthalene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1 mmol of 1,5-dimethoxynaphthalene was added to the reaction flask, dissolved in 2 mL of acetonitrile, and 145 uL of t-butyl nitrite was added. The mixture was stirred at room temperature for 24 hours. After the reaction was completed, the organic solvent was removed by a rotary evaporator. Solvent, column chromatography gave the product nitro product in a yield of 91%

The synthetic route of 1,5-Dimethoxynaphthalene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Xu Guangqiang; Xian Mo; Zhou Li; (11 pag.)CN108530242; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Brief introduction of 10075-63-5

General procedure: To a flask containing 1,3,5-trimethoxybenzene (1009.1 mg, 6 mmol) were added POCl3 (1011.9 mg, 6.6 mmol) and DMF (1754.1 mg, 24 mmol) at 0 C. After being stirred for 3 h at 40 C, DIH (2279.5 mg, 6 mmol) and aq ammonia (12 mL, 28-30%) were added to the reaction mixture. The obtained mixture was stirred for 3 h at rt. After the reaction, the mixture was poured into aq satd Na2SO3 solution and extracted with CHCl3 (3×20 mL). The organic layer was dried over Na2SO4, filtered, and evaporated to provide almost pure 2,4,6-trimethoxybenzonitrile (1156.1 mg) in 99% yield.

Reference:
Article; Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 68; 24; (2012); p. 4588 – 4595;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Introduction of a new synthetic route about C12H12O2

Synthetic Route of 10075-63-5,Some common heterocyclic compound, 10075-63-5, name is 1,5-Dimethoxynaphthalene, molecular formula is C12H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen, 300 mg (1.1 mmol) of 1,3,4-tri-O-acetyl-2,6-dideoxy-L-rhamnose and 620 mg (3.3 mmol) of 1,5-dimethoxynaphthalene After mixing with 30 mL of 1,2-dichloroethane, 27.94 mg (0.11 mmol) of I2 and 5.27 muL (0.033 mmol) of Et3SiH catalyst were added at a temperature of 25 C, and the TLC plate (PE: EA = 6: 1) to monitor the reaction, the reaction solution was isolated and purified to obtain 40.2 mg of the product as 3,4-di-O-acetyl-2,6-dideoxy-L-squirrel Sugar 1,5-dimethoxynaphthalene-beta-C-glycoside in a yield of 91%.