《A practical ortho-acylation of aryl iodides enabled by moisture-insensitive activated esters via palladium/norbornene catalysis》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Feng, Yunxia; Wang, Yangyang; Zhao, Shen; Zhang, Dao-Peng; Li, Xinjin; Liu, Hui; Dong, Yunhui; Sun, Feng-Gang. Computed Properties of C7H7IO The article mentions the following:
Polysubstituted aryl ketones I [R1 = 6-Me, 6-Cl, 4,6-di-Me, etc.] and II [R1 = C(O)Et, C(O)OEt, C(O)OtBu; R2 = cyclohexyl, thiophene-2-yl, 3-MeOC6H4, etc.] were synthesized via palladium/norbornene cooperative system catalyzed ortho-arene C-H acylation of aryl iodides using triazine esters. This ortho-acylation even proceeded smoothly in water. Preliminary mechanistic experiments indicated that the strong electron-withdrawing ability and coordination chem. of triazine play crucial roles in this transformation. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Computed Properties of C7H7IO)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Computed Properties of C7H7IO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem