Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 62257-15-2, name is 2-Fluoro-5-methoxyaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8FNO
2-Fluoronicotinic acid methyl ester (0.3 g, 1.934 mmol) and 2-fluoro-5-methoxyaniline(0.278 ml, 2.32 1 mmol) were heated by microwave irradiation at 130 C for 20 mm. SomeDCM was added and the mixture was washed twice with 1120. Organic phase was dried overNa2SO4, filtered and evaporated. Crude product was purified by trituration with diethylether. 0.324 g of the title compound was obtained.?H NMR (400 MHz, CDCJ3) oe ppm 3.82 (s, 3 H) 3.95 (s, 3 H) 6.49 (dt, 1 H) 6.78 (dd, I H) 7.03 (dd, I H) 8.27 (dd, I H) 8.33 (dd, I H) 8.42 (dd, 1 H) 10.42 (hr. s., I H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ORION CORPORATION; ARVELA, Riina; HOLM, Patrik; VESALAINEN, Anniina; WO2015/144976; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem