《Compatibility study of four binary combinations of active ingredients for dermal film forming systems》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Rusu, Aura; Ciurba, Adriana; Birsan, Magdalena; Antonoaea, Paula; Szekely-Szentmiklosi, Blanka; Fulop, Ibolya; Pascu, Giorgiana-Andreea; Todoran, Nicoleta. Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:
Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures – ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4) – combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fourier-transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC) and mol. modeling (MM) were used to characterize and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chem. interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
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