In 2022,Huang, Yunyuan; Xu, Haiyan; Wang, Pei; Gu, Rurong; Li, Xiaokang; Xu, Yixiang; Wang, Jiqun; Qiao, Sicong; Shi, Donglei; Gao, Zhaobing; Li, Jian published an article in ACS Chemical Neuroscience. The title of the article was 《Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation》.Application of 106685-40-9 The author mentioned the following in the article:
Combinatorial drug therapy has attracted substantial attention as an emerging strategy for the treatment of diseases with complex pathol. mechanisms. We previously developed a potentially universal computational screening approach for combination drugs and used this approach to successfully identify some beneficial combinations for the treatment of heart failure. Herein, this screening approach was used to identify novel combination drugs for the treatment of epilepsy in an approved drug library. The combination of guaifenesin-andrographolide was first discovered as a promising therapy with synergistic anticonvulsant activities in maximal electroshock (MES)- and s.c. pentylenetetrazol (s.c.-PTZ)-induced epilepsy models in vivo. The studies of network anal., fluorescence imaging, and N-methyl-D-aspartate (NMDA)-induced cytotoxicity further revealed that guaifenesin-andrographolide might synergistically affect NMDA receptors and then alleviate the pathogenesis of epilepsy. Therefore, we report that the combination of guaifenesin-andrographolide exerts effects against epilepsy through a novel synergistic mechanism and is thus a potential treatment for epilepsy, providing a promising mechanism for the design of novel combinatorial drug treatments against epilepsy. The results came from multiple reactions, including the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9
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Ether | (C2H5)2O – PubChem