In 2019,Organic & Biomolecular Chemistry included an article by Kumar, Vipin; Banert, Klaus; Ray, Devalina; Saha, Biswajit. Application of 882-33-7. The article was titled 《An atom-economical and regioselective metal-free C-5 chalcogenation of 8-aminoquinolines under mild conditions》. The information in the text is summarized as follows:
A general and simple metal-free protocol for expedient C-H functionalization leading to the regioselective generation of C-5 chalcogenated 8-aminoquinoline analogs I [R = H, Me, 5-(((tert-butoxy)carbonyl)amino)pentan-2-yl; R1 = H, OMe, Me; R2 = Ph, Pr, 4-chlorophenyl, etc.; Z = S, Se] in up to 90% yield at room temperature (25 °C) has been established. This methodol. is an eco-friendly approach to the atom-economical utilization of diaryl/dialkyl chalcogenides R2ZZR2 for direct access to chalcogenated quinolines and is scalable to the gram scale without considerable decrease in the yield of the product. It represents a practical alternative to the existing metal-catalyzed functionalization of 8-aminoquinoline derivatives with broad functional group tolerance. The controlled experiments suggest that the reaction possibly proceeds through an ionic pathway at room temperature Furthermore, the potentiality for the functionalization of free amines in chalcogenated-8-aminoquinolines I provides an attractive perspective for further elaboration of the amine substituent through chem. manipulations. The applicability of the standardized method has been augmented through late-stage antimalarial drug diversification of primaquine analogs. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7)
1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Application of 882-33-7 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem