Adding a certain compound to certain chemical reactions, such as: 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1836-62-0, Recommanded Product: 1836-62-0
2- (2-methoxyphenoxy) ethanamine (851 mg, 5.1 mmol),Benzaldehyde (540 mg, 5.1 mmol),Para-Toluenesulfonic acid (PTSA, 105 mg, 0.55 mmol) was dissolved in 5 mL of toluene.The mixed solution was refluxed, maintained and stirred.TLC (Thin Layer Chromatography) was used to confirm the completion of the reaction, and then the temperature was lowered to room temperature.The mixture was separated using water and ethyl acetate, and washed with a saturated aqueous sodium chloride solution. The organic layer was dried over magnesium sulphate and concentrated in vacuo to give crude product.The crude product prepared from the above was dissolved again in methanol (10 ml) at 0 C. Sodium borohydride (250 mg, 6.6 mmol) was slowly added dropwise and the temperature was raised to room temperature. After 24 hours of reaction, the mixture was diluted with dichloromethane and water. The diluted solution was extracted, separated and washed with a saturated aqueous sodium chloride solution three times. It was then dried over magnesium sulfate, concentrated in vacuo, and purified by flash column chromatography on silica gel, 10-50% ethyl acetate / hexane to finally yield the desired compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Methoxyphenoxy)ethylamine, and friends who are interested can also refer to it.
Reference:
Patent; Gachon University Industry Academy Cooperation Foundation; Kim Mi-hyeon; Kim Seon-yeo; Jang Cheong-yun; (29 pag.)KR2018/125090; (2018); A;,
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