Category: ethers-buliding-blocksIn 2020 ,《Ultrasound assisted synthesis of pyrazolo[1,5-a]pyrimidine-antipyrine hybrids and their anti-inflammatory and anti-cancer activities》 appeared in European Journal of Chemistry. The author of the article were Kaping, Shunan; Sunn, Melboureen; Singha, Laishram Indira; Vishwakarma, Jai Narain. The article conveys some information:
A series of antipyrinyl-pyrazolo[1,5-a]pyrimidines have been synthesized by reactions of aminopyrazole (4) with various formylated active proton compounds in the presence of KHSO4 (aqueous media), under ultrasound irradiation The structures of the compounds have been established with the help of spectral and anal. data. N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide (6a) was further subjected to X-ray crystallog. studies to avoid any ambiguity of the derived structures. Crystal data for compound 6a, C51H46N12O5 (M =907.00 g/mol): triclinic, space group P-1 (number 2), a = 9.9554(3) Å, b = 14.0875(4) Å, c = 17.4572(4) Å, a = 79.676(2)°, β= 85.283(2)°, γ= 72.647(2)°, V = 2297.97(11) Å3, Z = 2, T = 296.15 K, μ(MoKa) = 0.088 mm-1, Dcalc = 1.311 g/cm3, 29732 reflections measured (4.174° = 2T = 57.068°), 10681 unique (Rint = 0.0400, Rsigma = 0.0533) which were used in all calculations The final R1 was 0.0566 (I > 2s(I)) and wR2 was 0.1663 (all data). The novel compounds were also screened for their biol. activities. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem