《Trifarotene for the Treatment of Facial and Truncal Acne》 was written by Bell, Katheryn A.; Brumfiel, Caitlin M.; Haidari, Wasim; Boger, Laura. HPLC of Formula: 106685-40-9This research focused ontrifarotene treatment facial truncal acne; acne vulgaris; facial acne; retinoid; trifarotene; truncal acne. The article conveys some information:
This article reviews clin. trials to assess the efficacy, safety, and clin. application of trifarotene 0.005% cream (Aklief). A systematic review of the literature was performed using the terms trifarotene OR Aklief OR CD5789 in MEDLINE (PubMed) and EMBASE databases. Articles prior to May 2020 were considered for inclusion. Bibliogs. and ClinicalTrials.gov were also searched to identify further studies. Relevant English language and human studies related to pharmacol., clin. trials, and safety were considered. In the 52-wk phase III trial, treatment success rates for facial acne (Investigator Global Assessment [IGA] rating of no or almost no acne) and truncal acne (Physicianprimes Global Assessment [PGA] rating of no or almost no acne) were 65.1% and 66.9%, resp. Overall success rates (IGA and PGA success in the same patient) were 57.9%; 52.8% of patients had a Dermatol. Quality of Life Index score of 0 or 1, compared with 22.6% at baseline. Trifarotene was well tolerated, with pruritus, irritation, and sunburn as the most common adverse effects. Trifarotene is a newly Food and Drug Administration-labeled fourth-generation topical retinoid that shows particular promise in the treatment of facial and truncal acne vulgaris. It is an effective and safe addition to currently available retinoids. Trifarotene is effective and safe for treatment of facial and truncal acne. Future trials should compare its efficacy and tolerability with that of the older, clin. established retinoids. Despite efficacy, cost may be a prohibitive factor. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem