Electric Literature of C8H8O2In 2019 ,《Green one-pot multicomponent synthesis of pyrrolidinones using planetary ball milling process under solvent-free conditions》 appeared in Synthetic Communications. The author of the article were Khaligh, Nader Ghaffari; Mihankhah, Taraneh; Johan, Mohd Rafie. The article conveys some information:
A novel and efficient protocol was presented for the synthesis of pyrrolidinones I [R1 = H, 2-NO2, 4-Cl, etc.; R2 = Et, Me; R3 = H, 4-Me, 4-OMe, 4-NO2] via multicomponent condensation of benzaldehydes, dialkyl butynedioates and anilines using catalytic loading of 1,1′-butylene-bis(3-sulfo-3H-imidazol-1-ium)hydrogen sulfate as recyclable Bronsted acid ionic liquid through ball milling process at room temperature under solvent-free conditions. The developed method provided good to excellent yields of various pyrrolidinones in environmentally friendly conditions. Furthermore, this efficient protocol displayed a combination of the synthetic advantage of one-pot multicomponent reaction with ecol. benefits and convenience of a mechanochem. procedure. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)
2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem