Electric Literature of C9H12O2On October 22, 2015 ,《Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Taylor, Simon J.; Demont, Emmanuel H.; Gray, James; Deeks, Nigel; Patel, Aarti; Nguyen, Dung; Taylor, Maxine; Hood, Steve; Watson, Robert J.; Bit, Rino A.; McClure, Fiona; Ashall, Holly; Witherington, Jason. The article contains the following contents:
This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P 450 1A family during a lead optimization campaign for small mol. S1P1 agonists. Fold changes in mRNA up to 10 000-fold for CYP1A1 in vivo in rat and cynomolgus monkey and up to 45-fold for CYP1A1 and CYP1A2 in vitro in rat and human hepatocytes were observed Challenges observed with correlating induction in vitro and induction in vivo resulted in the implementation of a short, 4 day in vivo screening study in the rat which successfully identified noninducers. Subtle structure-activity relationships in this series of S1P1 agonists are described extending beyond planarity and lipophilicity, and the impact and considerations of AhR and CYP1A induction in the context of drug development are discussed. In addition to this study using (3-Methoxy-2-methylphenyl)methanol, there are many other studies that have used (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Electric Literature of C9H12O2) was used in this study.
(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Electric Literature of C9H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem