The author of 《A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin》 were He, Weiming; Zhang, Zhigao; Ma, Dawei. And the article was published in Angewandte Chemie, International Edition in 2019. COA of Formula: C9H10O2 The author mentioned the following in the article:
An efficient and scalable approach is described for the total synthesis of the marine natural product Et-743 (I) and its derivative lurbinectedin, II, which are valuable antitumor compounds The method delivers 1.6 % overall yield in 26 total steps from Cbz-protected (S)-tyrosine. It features the use of a common advanced intermediate to create the right and left parts of these compounds, and a light-mediated remote C-H bond activation to assemble benzo[1,3]dioxole-containing intermediate III. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2) was used in this study.
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem