《Development of a Robust Protocol for the Synthesis of 6-Hydroxybenzofuran-3-carboxylic Acid》 was written by Gallou, Isabelle; Erb, Bernhard; Marti, Michael; Nuzzo, Gian-Luca; Jager, Andreas; Seeger, Manuela; Chassagne, Pierre; Aronow, Jonas; Cortes-Clerget, Margery; Gallou, Fabrice. Recommanded Product: m-Methoxyphenol And the article was included in Organic Process Research & Development in 2020. The article conveys some information:
Benzofuran scaffolds are fundamental moieties found in a variety of biol. active natural products and synthetic drugs. In the course of one of our development programs, we needed to develop a practical and cost-effective manufacturing approach to such a benzofuran scaffold. Here we report a highly robust four-step, one-pot process that provides access to a 6-hydroxybenzofuran-3-carboxylic acid structure. An 1H NMR monitoring study allowed a better understanding of the overall sequence of events and the nature of the detected intermediates. After six steps, including the optimized tandem process, the desired hydroxylated benzofuran was obtained in 40% yield with a purity above 99%. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem