Application of 41789-95-1, A common heterocyclic compound, 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step D: To a cold (0 C. ) and stirred solution of 3-methoxy-N-benzylamine (46 g, 305 mmol) and diisoproplyethylamine (40 mL, 276 mmol) in CH2Cl2 (500 mL) was added the product obtained from Step C (71 g, 276 mmol) in CH2Cl2 (500 mL) solution. The reaction was then stirred at 0 C. for 2 hours. It was washed with water (500 mL), saturated aqueous NaHCO3 (500 mL), brine, dried and concentrated to give the desired product as a light yellow liquid (107 g, crude, quant.): 1H NMR (300 Hz, CDCl3) delta 8.43 (s, 1H), 7.94-7.92 (m, 2H), 7.51 (d, J=5.4 Hz, 1H), 7.40 (d, J=5.4 Hz, 1H), 7.25-7.21 (m, 1H), 6.93-6.80 (m, 3H), 3.83 (s, 2H), 3.76 (s, 3H), 3.67 (s, 2H), 2.40 (s, 3H); ESI-MS m/z 326 [M+H]+.
The synthetic route of 41789-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.; US2006/52378; (2006); A1;,
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