The author of 《Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII-Catalyzed Three-Component C-H Bond Addition to Internally Substituted Dienes and Carbonyls》 were Sun, Dongbang; Shen, Zican; Ellman, Jonathan A.. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:
An efficient CoIII-catalyzed three-component strategy to prepare homoallylic alcs. containing acyclic quaternary centers is disclosed. This transformation enables the introduction of two C-C σ bonds through C-H bond activation and sequential addition to internally substituted dienes and a wide range of aldehydes and activated ketones. Isoprene and other internally monosubstituted dienes are effective inputs, with the reaction proceeding with high diastereoselectivity for those substrate combinations that result in more than one stereogenic center. Moreover, the opposite relative stereochem. can be achieved by employing 1,2-disubstituted dienes. A mechanism for the transformation is proposed based upon the relative stereochem. of the products and studies with isotopically labeled starting materials. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Safety of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Safety of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem