The author of 《Radiosynthesis of a carbon-11-labeled AMPAR allosteric modulator as a new PET radioligand candidate for imaging of Alzheimer’s disease》 were Miao, Caihong; Dong, Fugui; Jia, Limeng; Li, Wei; Wang, Min; Zheng, Qi-Huang; Xu, Zhidong. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. SDS of cas: 10365-98-7 The author mentioned the following in the article:
Methoxyphenoxybenzothiadiazinedione I (R = 11CH3) was prepared as an allosteric PET ligand for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptor (AMPAR) for potential use as an imaging agent for Alzheimer’s disease. I (R = Me) and I (R = H) were prepared in eight and nine steps and 3% and 1% yields, resp. Methylation of I (R = H) with 11CH3OTf yielded I as the minor product in 10-15% radiochem. yield (based on [11C]CO2), with N4-methylation as the major reaction. The radiochem. purity was >99%, and the molar activity at end of bombardment (EOB) was 370-740 GBq/μmol with a total synthesis time of 35-40 min from EOB. The lipophilicity of I (R = 11CH3) and its N4-methylated isomer were determined and compared to the calculated lipophilicities for I (R = 11CH3) and its N4- and N2-methylated isomers. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem