《A click chemistry approach for the synthesis of cyclic ureido tethered coumarinyl and 1-aza coumarinyl 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis H37Rv and their in silico studies》 was written by Khanapurmath, Netravati; Kulkarni, Manohar V.; Joshi, Shrinivas D.; Anil Kumar, G. N.. Application of 150-19-6This research focused ontriazole preparation SAR mol docking antitubercular activity; 4-(Azidomethyl)-2H-chromen-2-ones/quinolin-2(1H)-ones; Click triazole; Mycobacterium tuberculosis H37Rv; Surflex-Dock algorithm. The article conveys some information:
Nucleoside bases like uracil, pharmacophoric triazoles and benzimidazolones have been used during the present study to design mol. matrixes for antitubercular activity, employing Click Chem. Click triazoles I (R = H, 6-Me, 6-OMe, 5,7-di-Me; X = O, NH), II (R = H, 6-Me, 6-OMe, 7-Me, 5,7-di-Me; X = O, NH), and III (R = H, 7-OMe, 6-Cl, 8-Me, etc.; X = O, NH) have been obtained by the reaction of 4-(azidomethyl)-2H-chromen-2-ones/quinolin-2(1H)-ones and propargyl ethers derived from theophylline/6-Me uracil/2-benzimidazolone resp. In addition to spectral data structures have been confirmed by single crystal X-ray diffraction studies in case of 6-methyl-1,3-di-prop-2-ynyl-1H-pyrimidine-2,4-dione and theophylline mono triazole I (R = 5,7-dimethyl). Theophylline linked mono triazoles, I and 6-Me uracil linked bis triazoles, II have been found to inhibit Mycobacterium tuberculosis H37Rv with MIC values in the range 55.62-115.62μM. Benzimidazolone bis triazoles, III showed better activity with MIC in the range 2.33-18.34μM. Mol. modeling studies using Surflex-Dock algorithm supported the results. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Application of 150-19-6) was used in this study.
m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem