Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H6BrFO
a) 3-Bromo-6-fluoro-2-methoxybenzoic acid I45 To a solution of diisopropylamine (5.4 g, 53.7 mmol) in THF (150 ml.) at -78 C under N2 was added n-BuLi (2.5 M solution in hexanes, 23.4 ml_, 58.5 mmol) dropwise and the mixture was stirred at -78 C for 1 h. The resulting mixture was added dropwise to a solution of 1-bromo-4-fluoro-2-methoxybenzene (10.0 g, 48.8 mmol) in THF (50 ml.) at -78 C and stirring was continued for 90 min. C02 was bubbled through the mixture for 20 min with stirring at -78 C, then allowed to warm to RT and stirred for 15 min. The reaction mixture was adjusted to pH=1 with HCI and the mixture was diluted with water and extracted with DCM (500 ml_). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (DCM/MeOH = 100/1 to 30/1) to give the title compound (8.0 g, 66%) as a colorless oil. LCMS-D: Rt2.12 min; m/z 248.9/250.9 [M+H]+.
According to the analysis of related databases, 450-88-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CTXT PTY LIMITED; STUPPLE, Paul, Anthony; LAGIAKOS, Helen, Rachel; MORROW, Benjamin, Joseph; FOITZIK, Richard, Charles; HEMLEY, Catherine, Fae; CAMERINO, Michelle, Ang; BOZIKIS, Ylva, Elisabet, Bergman; WALKER, Scott, Raymond; (321 pag.)WO2019/243491; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem