Moraes, Maiara C.; Lenardao, Eder J.; Barcellos, Thiago published their research in ARKIVOC (Gainesville, FL, United States) in 2021. The article was titled 《Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis》.SDS of cas: 150-19-6 The article contains the following contents:
A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Bronsted acid catalyst. Fifteen examples were prepared with moderate to excellent yields (50% to 90%) using 10 mol % of the catalyst. Furthermore, it was possible from the proposed methodol. to scale up the synthesis of coumarins to obtain up to 11 g of product. This work also provides a preliminary insight into the reaction mechanism using high-resolution mass spectrometry anal. The key cinnamic acid derivative intermediate was detected, implying that under the evaluated conditions, the mechanistic pathway starts with an aromatic electrophilic substitution followed by dehydration reaction and intramol. transesterification. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6SDS of cas: 150-19-6)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSDS of cas: 150-19-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem