Application of 4637-24-5In 2022 ,《Insights into the crystal structure of two newly synthesized quinoxalines derivatives as potent inhibitor for c-Jun N-terminal kinases》 appeared in Journal of Biomolecular Structure and Dynamics. The author of the article were Abad, Nadeem; El Bakri, Youness; Lai, Chin-Hung; Karthikeyan, Subramani; Ramli, Youssef; Ferfra, Souad; Mague, Joel T.; Essassi, El Mokhtar. The article conveys some information:
Two new compounds namely, Et (2E)-3-(dimethylamino)-2-(3-methoxyquinoxalin-2-yl)propen-2-enoate () and Et 2-(3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydroquinoxalin-2-yl)-3-phenylpropanoate () have been synthesized from Et 2-(oxo-3,4-dihydroquinoxalin-2-yl) acetate (). The compounds were characterized using NMR (1H and 13C), Fourier transform IR and confirmed by single crystal X-ray diffraction studies. The quinoxaline portion of is almost planar with the substituent containing the dimethylamino and carboxyethyl groups rotated well out of its mean plane. In the crystal, C-H···O and C-H···N hydrogen bonds as well as C-H···Π(ring) interactions form chains having a U-shaped cross-section and running along the c-axis direction. Two sets of pair-wise C-H···O hydrogen bonds connect the chains into corrugated sheets. In, the three substituents on the dihydroquinoxaline moiety are rotated well out of its mean plane. Three sets of C-H···O hydrogen bonds as well as C-H···π(ring) and π-π-stacking interactions form layers approx. parallel to [001]. These are associated along the c-axis direction by addnl. C-H···π(ring) interactions. Addnl., the Hirshfeld surface analyses showed that the H···H contact is the most important interaction for both and In addition to this, mol. docking and dynamics studies were carried for these two compounds with the c-Jun N-terminal kinases (JNK1) mol.Communicated by Ramaswamy H. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application of 4637-24-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem