Ritchie, Nina F. C.; Zahara, Adam J.; Wilkerson-Hill, Sidney M. published an article in 2022. The article was titled 《Divergent Reactivity of α,α-Disubstituted Alkenyl Hydrazones: Bench Stable Cyclopropylcarbinyl Equivalents》, and you may find the article in Journal of the American Chemical Society.Application In Synthesis of 1-Bromo-3-methoxybenzene The information in the text is summarized as follows:
The divergent reactivity of 2,2-dialkyl-3-(E)-alkenyl N-tosylhydrazones using Pd-catalyzed cross-coupling conditions, which enabled the Z-selective synthesis of 3-aryl-1,4-dienes and gem-dialkyl vinylcyclopropanese. It was found that the dialkylbiaryl phosphine ligand SPhos was the optimal ligand for this transformation producing skipped dienes in up to 83% isolated yield. The ratio of skipped diene to vinylcyclopropane was dependent on both the structure of the α,α-disubstituted hydrazones and the aryl halide component. Using sterically encumbered aryl bromides provided the trans-cyclopropane products selectively in up to 69% yield. The reaction was stereospecific and stereoselective and occurs alongside a competing 1,2-vinyl group migration pathway. The results came from multiple reactions, including the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene
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