The author of 《Facile Process for Metallizing DNA in a Multitasking Deep Eutectic Solvent for Ecofriendly C-C Coupling Reaction and Nitrobenzene Reduction》 were Chakraborty, Supratim; Mruthunjayappa, Manohara Halanur; Aruchamy, Kanakaraj; Singh, Nripat; Prasad, Kamalesh; Kalpana, Dharmalingam; Ghosh, Debasis; Sanna Kotrappanavar, Nataraj; Mondal, Dibyendu. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Formula: C7H9BO3 The author mentioned the following in the article:
Metalized DNA is an exciting functional material having widespread utility toward multifunctional applications. However, conventional DNA metalization processes are time-consuming and multistep and, most importantly, the helicity of DNA is destroyed during the metalization process. Herein, an ecofriendly and rapid approach was demonstrated to metalize salmon milt DNA with Pd and Fe3O4 in deep eutectic solvent (DES; ChoCl-EG 1:2 mol ratio) without disturbing the structural integrity of the biopolymer. Besides maintaining the stability of DNA at high temperature, DES played the dual role of (i) a solvent for DNA metalization and (ii) a reducing agent for reduction of Pd(II) to Pd(0) during the metalization process. Microscopic studies confirmed the stepwise formation of aggregated coil type morphol. in metalized DNA (Pd-DNA-Fe3O4). Whereas, the interactions between Pd and Fe3O4 with DNA in Pd-DNA-Fe3O4 were probed by different anal. tools, which suggested that Pd interacted with phosphate groups and Fe3O4 interacted with the base pairs of DNA. CD spectroscopy anal. established that the B-form of DNA was maintained before and after the metalization process. After successful metalization, Pd-DNA-Fe3O4 was utilized as a nanobiocatalyst for Suzuki coupling reaction and reduction of nitrobenzene to aniline. The metalized DNA showed remarkable catalytic activity and efficiency for sustainable Suzuki coupling reaction in DES. Under optimized conditions, 100% conversion of the substrates was recorded with 100% selectivity of the desired C-C coupled product. Taking advantage of the high temperature stability of DNA in DES, the recyclability (up to 6 cycles) potential of both metalized DNA and DES toward C-C coupling was explored without significant loss in the catalytic activity, thus demonstrating the green aspects of the process. When utilized as a catalyst for the reduction of nitrobenzene to aniline, ∼90% conversion of nitrobenzene was achieved with 66% selectivity of aniline which suggested that the overall assembly of metalized DNA is a efficient system to carry out facile nitrobenzene reduction Overall, the present study demonstrates a general process for metalization of DNA in DES and the applications of the metalized DNA as a catalyst in different organic reactions. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Formula: C7H9BO3)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Formula: C7H9BO3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem