The author of 《Synthesis of site-specific crown ether adducts to DNA abasic sites: 8-oxo-7,8-dihydro-2′-deoxyguanosine and 2′-deoxycytidine》 were An, Na; Fleming, Aaron M.; Rosecrans, Nicole C.; Liao, Yi; Burrows, Cynthia J.. And the article was published in Methods in Molecular Biology (New York, NY, United States) in 2019. SDS of cas: 33100-27-5 The author mentioned the following in the article:
Formation of adducts to DNA is of great benefit to DNA sequencing and damage detection technol. and to enzymol. Here we describe the synthesis and characterization procedures of 18-crown-6 adducts formed to abasic (AP) sites, 8-oxo-7,8-dihydro-2′-deoxyguanosine (OG), and 2′-deoxycytidine (C) residues in DNA oligodeoxynucleotides. These crown ether adducts were used as site-specific modifications to facilitate nanopore technol. The methods described can be readily expanded to attach other suitable primary amines of interest. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)
1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem