Comins, Daniel L.; Brown, Jack D. published the artcile< Ortho metalation directed by α-amino alkoxides>, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde, the main research area is metalation ortho amino alkoxide directed; lithiation ortho amino alkoxide directed; regiochemistry lithiation ortho aromatic aldehyde.
Adding benzaldehydes and naphthaldehydes to Li dialkylamides gave α-amino alkoxides, which were ortho-lithiated with excess BuLi and then alkylated and hydrolyzed to give o-substituted aromatic aldehydes. Using Me2NCH2CH2NHMe as the amine gave metalation at lower temperatures due to intramol. amine-assisted metalation. The synthetic utility of this ortho metalation, including how varying the amine component of the α-amino alkoxide affects the regiochem. and metalation rate, was discussed.
Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem