Shang, Yaping; Jonnada, Krishna; Yedage, Subhash Laxman; Tu, Hua; Zhang, Xiaofeng; Lou, Xin; Huang, Shijun; Su, Weiping published the artcile< Rhodium(III)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is alkyl indole preparation; internal alkyne aniline transient oxidizing directing group rhodium catalyst.
Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compds I (R1 = Me, allyl, C6H5, etc.; R2 = 5-Me, 6-CH2OMe, 5-NO2, etc.) and II (R1 = Me, Et, i-Pr, etc.; R2 = H, 5-Me, 5-CO2Me, etc.; R3 = n-Bu, C6H5, 4-MeC6H5, etc.; R4 = Me, COMe, 3-FC6H5, etc.). This work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem