Sakai, Norio; Sasaki, Kazuki; Suzuki, Hiroki; Ogiwara, Yohei published the artcile< One-pot synthesis of α-halo β-amino acid derivatives via the difunctional coupling of ethyl α-diazoacetate with silyl halides and N,O-acetals or aromatic tertiary amines>, HPLC of Formula: 10541-78-3, the main research area is halo beta amino acid ester synthesis solvent effect; ethyl diazoacetate difunctionalization silyl halide acetal aromatic tertiary amine; three component coupling reaction iminium intermediate.
The difunctionalization of Et α-diazoacetate (EDA) using silyl halides as a nucleophile and N,O-acetals as an electrophile under metal-free conditions is described. This process undergoes a novel three-component coupling (3-CC) reaction using EDA, which leads to a one-pot preparation of α-halo β-amino acid esters. Also, this protocol could be adapted to accept an electrophile composed of aromatic tertiary amines. In both 3-CC reactions, the key reaction intermediate is an iminium intermediate that can be easily and effectively generated either from N, O-acetals or from aromatic tertiary amines.
Synthesis published new progress about Multicomponent reaction. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, HPLC of Formula: 10541-78-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem