Aikawa, Haruo; Tago, Sakie; Umetsu, Kazuteru; Haginiwa, Naomichi; Asao, Naoki published the artcile< Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is alkynylbenzoic acid alkyl ester alc gold etherification; ether preparation; gold etherification catalyst; alkylating agent alkynylbenzoic acid alkyl ester.
Ortho-Alkynylbenzoic acid alkyl esters behave as alkylating agents in combination with gold catalysts. The reaction with alcs. occurs smoothly in the presence of catalytic amounts of Ph3PAuCl and AgOTf under mild conditions to produce the corresponding ether products in high yields. The protocol is also useful for Friedel-Crafts alkylation and N-alkylation of sulfonamides. The reaction likely proceeds through the gold-induced in situ construction of leaving groups and subsequent nucleophilic attack of nucleophiles, such as alcs., aromatic compounds, and sulfonamides.
Tetrahedron published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem